Impaired incretin secretion and pancreatic dysfunction with older age and diabetes

Geloneze, Bruno; Oliveira, Maria da Saúde de; Vasques, Ana Carolina Junqueira; Novaes, Fernanda Satake; Pareja, José Carlos; Tambascia, Marcos Antônio

doi:10.1016/j.metabol.2014.04.004

Cited by 36 publications

(22 citation statements)

References 39 publications

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“…This age-related alteration in insulin sensitivity seems not due to intrinsic ageing but rather to a decrease in physical activity or to modification of body composition (especially a rise in fat mass which contributes to the age-associated lipotoxicity), events that are often observed during ageing in rats and human subjects (77)(78)(79) . However, ageing could also contribute to glucose metabolism disorders through a decrease in secretory capacity of β-cells in response to glucose as was shown in humans (80)(81)(82) . All of these dysregulations may lead to type 2 diabetes, and it is well established that type 2 diabetes prevalence increases with age.…”

Section: Nutrition Research Reviewsmentioning

confidence: 99%

Similarities and interactions between the ageing process and high chronic intake of added sugars

et al. 2017

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In our societies, the proportions of elderly people and of obese individuals are increasing. Both factors are associated with high health-related costs. During obesity, many authors suggest that it is a high chronic intake of added sugars (HCIAS) that triggers the shift towards pathology. However, the majority of studies were performed in young subjects and only a few were interested in the interaction with the ageing process. Our purpose was to discuss the metabolic effects of HCIAS, compare with the effects of ageing, and evaluate how deleterious the combined action of HCIAS and ageing could be. This effect of HCIAS seems mediated by fructose, targeting the liver first, which may lead to all subsequent metabolic alterations. The first basic alterations induced by fructose are increased oxidative stress, protein glycation, inflammation, dyslipidaemia and insulin resistance. These alterations are also present during the ageing process, and are closely related to each other, one leading to the other. These basic alterations are also involved in more complex syndromes, which are also favoured by HCIAS, and present during ageing. These include non-alcoholic fatty liver disease, hypertension, neurodegenerative diseases, sarcopenia and osteoporosis. Cumulative effects of ageing and HCIAS have been seldom tested and may not always be strictly additive. Data also suggest that some of the metabolic alterations that are more prevalent during ageing could be related more with nutritional habits than to intrinsic ageing. In conclusion, it is clear that HCIAS interacts with the ageing process, accelerates the accumulation of metabolic alterations, and that it should be avoided.

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Section: Nutrition Research Reviewsmentioning

confidence: 99%

Similarities and interactions between the ageing process and high chronic intake of added sugars

et al. 2017

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“…Вероятно, с этим фактом связано значительное повы-шение постпрандиальной гликемии после 50 лет [8]. Имеются данные о том, что у пожилых лиц секреция глюкозозависимого инсулинотропного пептида (ГИП) сопоставима с таковой у более молодых, а глюкагоно-подобного пептида 1 (ГПП-1) -снижена [9]. Последние исследования показывают, что нарушения метаболизма глюкозы связаны со старением, но не являются его не-обходимым компонентом [10].…”

Section: патофизиология углеводного обмена у пожилыхunclassified

Diabetes type 2 diabetes in the elderly – solved and unsolved questions

Саприна¹,

Fajzulina²

2016

Diabetes mellitus

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Диагностика, контроль, лечение Diagnosis, control, treatment тремительное старение населения во всем мире представляет собой одно из самых значимых демографических, социально-экономиче-ских и политических преобразований нашего времени. По данным ООН, доля лиц в возрасте 60 лет и старше удвоится в период между 2007 и 2050 гг., а их реальное число увеличится более чем в три раза, до-стигнув 2 млрд в 2050 г. [1]. Данная проблема требует коренных изменений в системе здравоохранения для предоставления комплексной помощи, учитывающей особые потребности пожилых людей. В 2015 г. Всемир-ной Организацией Здравоохранения опубликован Все-мирный доклад о старении и здоровье, в котором авторы подчеркивают крайнюю актуальность данной проблемы и рекомендуют массовые исследования пожилых людей для выявления уровня функциональной способности, конкретного состояния здоровья, потребности в меди-цинской помощи, уходе и поддержке для поддержания «здорового старения» [2].Рост распространенности сахарного диабета 2 типа (СД2) является следствием старения населения. Со-гласно данным International Diabetes Federation (IDF), 415 млн взрослых людей в возрасте 20-79 страдают диа-бетом во всем мире, а распространенность диабета у лиц старше 65 лет достигает 20% [3]. В России в настоящее время, по данным Государственного регистра больных СД, на январь 2015 г. зарегистрировано 4,095 млн боль-ных СД, что составляет 2,8% населения РФ. За 5-летний период рост распространенности СД в РФ составил 23% (930 тыс. пациентов) [4]. По данным российских иссле-дователей, распространенность СД2 возрастала после 50 лет от 3,0% в возрастной группе 41-50 лет до 10,6% в возрастной группе 51-60 лет, достигая максимума у лиц старше 70 лет -12,6% [5].Согласно классификации, принятой европейским региональным бюро ВОЗ в 1963 г., пожилым считается возраст от 60 до 74 лет, старческим -от 75 до 89 лет, а возрастом долгожителей -90 лет и более. До настоя-щего времени эта классификация не пересмотрена. В большинстве американских и европейских исследо-ваний критерием пожилого возраста является возраст 65 лет и старше, однако рассматриваются и другие воз-растные группы населения, такие как 50 лет и старше, 60 лет и старше и 80 лет и старше. Американская диабети- Сахарный диабет 2 типа у лиц пожилого возраста -решенные и нерешенные вопросы

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“…By examining middle-aged as compared to older individuals with and without type 2 diabetes, Geloneze et al (33) attempted to determine whether and how diabetes and aging may interact to alter insulin sensitivity and incretins. They examined cross-sectionally 25 middle-aged participants (aged 45 ± 3 years), of which 13 had type 2 diabetes, as compared to 25 older adults (aged 65 ± 2 years), of which 13 had diabetes.…”

Section: Novel Findings In Type 2 Diabetes and Insulin Sensitivitymentioning

confidence: 99%

New research developments and insights from Metabolism

2015

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In a field of great importance to daily life and clinical care, metabolic-related research covers a wealth of information and knowledge. This broad field encompasses a number of physical states that are increasingly critical to study, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Additionally, the impacts of diet, nutrition, and exercise on these physical states are an area of ever-important and expanding research. With the latest advances in metabolic research, much knowledge has been gained. Here, we present the newest findings from research published in Metabolism. We hope that these results provide not only critical knowledge needed for clinical care and daily life, but also a platform for the continuing expansion of research into metabolic-related issues.

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Impaired incretin secretion and pancreatic dysfunction with older age and diabetes

Cited by 36 publications

References 39 publications

Similarities and interactions between the ageing process and high chronic intake of added sugars

Similarities and interactions between the ageing process and high chronic intake of added sugars

Diabetes type 2 diabetes in the elderly – solved and unsolved questions

New research developments and insights from Metabolism

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