2013
DOI: 10.1503/jpn.120138
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Impaired inhibition of prepotent motor actions in patients with Tourette syndrome

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Cited by 44 publications
(37 citation statements)
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“…Changes in reinforcement learning and in action control (e.g., inhibitory motor control) are reported in many of the most common psychiatric and neurologic basal ganglia disorders, including Obsessive-Compulsive Disorder (Gillan et al, 2011; Marsh et al, 2015), Tourette's Syndrome (Worbe et al, 2011; Wylie et al, 2013), Parkinson's Disease (Wylie et al, 2009ab; Frank, 2005), and Huntington's Disease (Lawrence et al, 1999; Holl et al, 2013), but have been studied in isolation. A first question will be to determine if different forms of basal ganglia dysfunction alter the action-valence learning biases in dissociable ways.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Changes in reinforcement learning and in action control (e.g., inhibitory motor control) are reported in many of the most common psychiatric and neurologic basal ganglia disorders, including Obsessive-Compulsive Disorder (Gillan et al, 2011; Marsh et al, 2015), Tourette's Syndrome (Worbe et al, 2011; Wylie et al, 2013), Parkinson's Disease (Wylie et al, 2009ab; Frank, 2005), and Huntington's Disease (Lawrence et al, 1999; Holl et al, 2013), but have been studied in isolation. A first question will be to determine if different forms of basal ganglia dysfunction alter the action-valence learning biases in dissociable ways.…”
Section: Discussionmentioning
confidence: 99%
“…A central component of cognitive control in times of conflict is the inhibition of conflicting response alternatives, which has been linked to frontal projections to basal ganglia that engage the indirect and hyperdirect basal ganglia pathways to brake actions selectively (Aron et al, 2007; Jahfari et al, 2011; Mink, and Thach, 1993). Disorders associated with basal ganglia dysfunction produce pronounced deficits in conflict resolution and inhibitory control, and pharmacological (e.g., dopamine) and deep brain stimulation manipulations of basal ganglia function modulate these processes directly (Gillan et al, 2011; Holl et al, 2013; Worbe et al, 2011; Wylie et al, 2009a, 2009b, 2010, 2012, 2013). …”
Section: Introductionmentioning
confidence: 99%
“…These forms of cognitive control are separable experimentally and have been linked to frontal-basal ganglia circuitries (Aron et al, 2007; Forstmann et al, 2008a, b, c; Jahfari et al, 2011; Gillan et al, 2011; Holl et al, 2013; van den Wildenberg et al, 2010; Worbe et al, 2011). Studies show their compromise in Parkinson’s disease and their modulation by dopamine pharmacotherapy (Wylie et al, 2009a, b, 2010a, b, 2012a, b, 2013). These control mechanisms are crucial for navigating dynamic, action-oriented environments that may trigger conflicting, undesired, or impulsive response tendencies.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies have attempted to address TS as a generalized failure of action inhibition, but that conceptualization may cast the net too wide 79 . A 2013 publication from Wylie et al 10 had suggested some deficit in response inhibition (action stopping) in TS. In 2016, the group reported a new study in young adults with TS, now better controlled for comorbidity 11 .…”
Section: Resultsmentioning
confidence: 99%