Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations

Berenson, Charles S.; Kruzel, Ragina L.; Eberhardt, Ellana; Dolnick, Ree Y.; Minderman, Hans; Wallace, Paul K.; Sethi, Sanjay

doi:10.1136/thoraxjnl-2013-203669

Cited by 85 publications

(79 citation statements)

References 35 publications

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“…In agreement, we observed that cell pretreatment with sublethal AZM doses may also improve macrophage phagocytic function to ingest NTHI. These data should be considered in the context of the COPD patient, given that several studies have reported alterations in alveolar macrophage activity in COPD patients (66)(67)(68)(69). These alterations include defective immune responsiveness in terms of diminished IL-8, tumor necrosis factor alpha (TNF-␣), and IL-1␤ responses (69), impaired phagocytosis (66,68), and dysfunctional innate responses associated with impaired Toll-like receptors (TLRs) (67).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Euba

Moleres

Viadas

et al. 2015

Antimicrob Agents Chemother

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Section: Discussionmentioning

confidence: 99%

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Euba

Moleres

Viadas

et al. 2015

Antimicrob Agents Chemother

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“…Third, an abnormal lung microbiome has been reported in patients with COPD [52] and it is known that smoking restricts the ability of alveolar macrophages to phagocytose and kill bacteria [53], suggesting that cigarette smoke may lead to an immune defect of the lung microbiome. There is evidence that Gram-negative bacteria of the enteric microflora may also be part of the lung microbiota [54,55], micro-organisms that are resistant to cigarette smoking [56] and may contribute to severe exacerbations of COPD [55].…”

Section: Respiratory Tractmentioning

confidence: 99%

Inflammatory bowel diseases, chronic liver diseases and the lung

Rodríguez-Roisin

Bartolome

Huchon³

et al. 2016

Eur Respir J

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This review is devoted to the distinct associations of inflammatory bowel diseases (IBD) and chronic liver disorders with chronic airway diseases, namely chronic obstructive pulmonary disease and bronchial asthma, and other chronic respiratory disorders in the adult population. While there is strong evidence for the association of chronic airway diseases with IBD, the data are much weaker for the interplay between lung and liver multimorbidities. The association of IBD, encompassing Crohn's disease and ulcerative colitis, with pulmonary disorders is underlined by their heterogeneous respiratory manifestations and impact on chronic airway diseases. The potential relationship between the two most prevalent liver-induced pulmonary vascular entities, i.e. portopulmonary hypertension and hepatopulmonary syndrome, and also between liver disease and other chronic respiratory diseases is also approached. Abnormal lung function tests in liver diseases are described and the role of increased serum bilirubin levels on chronic respiratory problems are considered. @ERSpublications Lung-gut cross-talk: the association of IBD with respiratory multimorbitidies, including COPD and bronchial asthma

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“…The macrophages present become ineffective in removing respiratory invading pathogens along with weakened Toll-like receptors (TLRs), which then results in bacterial growth. 21 Even in the presence of a high number of neutrophils, local and systemic hypoxia hampers neutrophils from killing bacteria, delayed apoptosis, and enhanced release of proteases. 22 The alveolar macrophages of adults with COPD have impaired inflammatory cytokine responsiveness to nontypeable Haemophilus influenzae outer membrane proteins P6 (a TLR).…”

Section: Disease Development and Molecular Changesmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Ventilator-Associated Pneumonia

Toney

Lynch-Smith²

2016

Dimensions of Critical Care Nursing

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The occurrence of ventilator-associated pneumonia (VAP) infections in mechanically ventilated patients has significantly affected how medical providers manage the severe acute pulmonary pathology in chronic obstructive pulmonary disease (COPD) and implement medical interventions to prevent infectious transmission to these patients in the intensive care unit. Severe COPD is present in more than 65 million people worldwide, thereby placing these individuals at an increased risk of intensive care unit admission and VAP contraction. Chronic obstructive pulmonary disease is well known as a risk factor for developing VAP and is related to adverse risk factors such as developing multiple drug-resistant bacteria. Evidence shows that COPD immunosuppression continues to be associated with pulmonary infection, but multiple modalities are available to combat and treat acute exacerbations before decompensation begins, thereby preventing prolonged endotracheal mechanical ventilation.

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Impaired innate immune alveolar macrophage response and the predilection for COPD exacerbations

Cited by 85 publications

References 35 publications

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection

Inflammatory bowel diseases, chronic liver diseases and the lung

Chronic Obstructive Pulmonary Disease and Ventilator-Associated Pneumonia

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