Impaired insulin secretion and related factors in East Asian individuals

Nakamura, Akinobu; Terauchi, Yasuo

doi:10.1111/jdi.13650

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…T2D is characterized by impaired insulin secretion and/or insulin sensitivity [31] and sustained by chronic subclinical inflammation. Recent results [13] have revealed the possibility of using particular β-conglutin proteins to prevent and treat diabetes and their potential as anti-inflammatory molecules.…”

Section: β-Conglutin Protein Inhibits the Gene Expression Of Differen...mentioning

confidence: 99%

β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.)

Lima-Cabello

Escudero-Feliú

Peralta-Leal

et al. 2023

IJMS

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Narrow-leafed lupin (NLL; Lupinus angustifolius L.) has multiple nutraceutical properties that may result from unique structural features of β-conglutin proteins, such as the mobile arm at the N-terminal, a structural domain rich in α-helices. A similar domain has not been found in other vicilin proteins of legume species. We used affinity chromatography to purify recombinant complete and truncated (without the mobile arm domain, tβ5 and tβ7) forms of NLL β5 and β7 conglutin proteins. We then used biochemical and molecular biology techniques in ex vivo and in vitro systems to evaluate their anti-inflammatory activity and antioxidant capacity. The complete β5 and β7 conglutin proteins decreased pro-inflammatory mediator levels (e.g., nitric oxide), mRNA expression levels (iNOS, TNFα, IL-1β), and the protein levels of pro-inflammatory cytokine TNF-α, interleukins (IL-1β, IL-2, IL-6, IL-8, IL-12, IL-17, IL-27), and other mediators (INFγ, MOP, S-TNF-R1/-R2, and TWEAK), and exerted a regulatory oxidative balance effect in cells as demonstrated in glutathione, catalase, and superoxide dismutase assays. The truncated tβ5 and tβ7 conglutin proteins did not have these molecular effects. These results suggest that β5 and β7 conglutins have potential as functional food components due to their anti-inflammatory and oxidative cell state regulatory properties, and that the mobile arm of NLL β-conglutin proteins is a key domain in the development of nutraceutical properties, making NLL β5 and β7 excellent innovative candidates as functional foods.

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Section: β-Conglutin Protein Inhibits the Gene Expression Of Differen...mentioning

confidence: 99%

β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.)

Lima-Cabello

Escudero-Feliú

Peralta-Leal

et al. 2023

IJMS

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“…The pathophysiology of type 2 diabetes is characterized by increased insulin resistance and decreased insulin secretion [1]. Regarding decreased insulin secretion, the function and mass of insulin-secreting pancreatic betacells progressively decrease before the onset of diabetes [2][3][4][5][6][7]. However, it is not easy to accurately evaluate betacell function over time to assess the pathophysiology and therapeutic intervention in humans.…”

Section: Introductionmentioning

confidence: 99%

Glucokinase as a therapeutic target based on findings from the analysis of mouse models

Nakamura

2022

Endocr J

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I investigated mouse models to elucidate the pathophysiology and to establish a new treatment strategy for type 2 diabetes, with a particular focus on glucokinase. The decrease in pancreatic beta-cell function and mass are important factors in the pathophysiology of type 2 diabetes. My group have shown that glucokinase plays an important role in high-fat dietinduced and high-starch diet-induced beta-cell expansion. The findings indicated that the mechanism of short-term high-fat diet-induced beta-cell proliferation involved a glucokinase-independent pathway, suggesting that there are different pathways and mechanisms in the proliferation of pancreatic beta-cells during short-term versus long-term high-fat diets. Because enhancement of glucose signals via glucokinase is important for beta-cell proliferation, it was thought that beta-cell mass would be increased and insulin secretion would be maintained by glucokinase activators. However, sub-chronic administration of a glucokinase activator in db/db mice produced an unsustained hypoglycemic effect and promoted hepatic fat accumulation without changes in beta-cell function and mass. In contrast, my group have shown that inactivating glucokinase in beta-cells prevented beta-cell failure and led to an improvement in glucose tolerance in db/db mice. Regulation of glucokinase activity has an influence on the pathophysiology of type 2 diabetes and can be one of the therapeutic targets.

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Impaired insulin secretion and related factors in East Asian individuals

Cited by 2 publications

References 19 publications

β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.)

β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.)

Glucokinase as a therapeutic target based on findings from the analysis of mouse models

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