Impaired leptin response to glucocorticoid as a chronic complication of diabetes

Dagogo‐Jack, Samuel; Liu, Jianmei; Askari, Hasan; Tykodi, Gunjan; Umamaheswaran, Indira

doi:10.1016/s1056-8727(00)00090-8

Cited by 14 publications

(8 citation statements)

References 34 publications

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“…To our knowledge, these potentially informative studies have not been undertaken. In our previous study of type 2 diabetes patients, we found impaired leptin responses to glucocorticoid in patients with long‐standing (30) but not newly diagnosed diabetes (31). The latter suggests a possible role for residual β‐cell function in the orchestration of glucocorticoid responsiveness in diabetic subjects.…”

Section: Discussionmentioning

confidence: 76%

Leptin Response to Glucocorticoid Occurs at Physiological Doses and Is Abolished by Fasting

et al. 2003

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DAGOGO-JACK, SAMUEL, INDIRA UMAMAHES-WARAN, HASAN ASKARI, AND GUNJAN TYKODI.Leptin response to glucocorticoid occurs at physiological doses and is abolished by fasting. Obes Res. 2003; 11:232-237. Objective: To examine the effects of graded doses of hydrocortisone (HC) on leptin secretion, and determine the effect of fasting. Research Methods and Procedures:This was a randomized, placebo-controlled, crossover study, with a 1-week "washout" period between interventions. Eight healthy subjects [age ϭ 36 Ϯ 2.3 years (ϮSE), body mass index ϭ 31.5 Ϯ 1.6 kg/m 2 ] completed the dose-response study in which an intravenous infusion of saline (placebo) or HC (30 or 100 mg) was administered for 24 hours. Four healthy subjects (age ϭ 35.2 Ϯ 3.0 years, body mass index ϭ 27.1 Ϯ 2.1 kg/m 2 ) completed the fasting study, which entailed continuous infusion of saline, HC (300 mg/24 hours) in the fed state, or HC (300 mg/24 hours) with total caloric deprivation for 24 hours. Blood sampling was performed every 1 to 2 hours for measurement of leptin, cortisol, insulin, and glucose levels. Results: Peak hyperleptinemia occurred after 16 hours of HC infusion; peak/baseline leptin levels were 129% (placebo), 140% (30 mg of HC for 24 hours, p ϭ 0.05), and 185% (100 mg of HC for 24 hours, p Ͻ 0.01). During infusion of HC (300 mg/24 hours or placebo), the peak/ baseline plasma leptin levels were 16.1 Ϯ 5.8/12.8 Ϯ 5.9 ng/mL (placebo with food, 126%), 14.6 Ϯ 6.0/12.5 Ϯ 6.5 ng/mL (HC fasting, 117%), and 32.5 Ϯ 12.5/12.0 Ϯ 8.4 ng/mL (HC with food, 271%, p Ͻ 0.001). Discussion: Leptin secretory responses occur at physiological doses of HC, are obliterated by fasting, and thus may be of metabolic significance.

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Section: Discussionmentioning

confidence: 76%

Leptin Response to Glucocorticoid Occurs at Physiological Doses and Is Abolished by Fasting

et al. 2003

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“…The adipokine leptin also has roles related to the control of metabolism and energy homeostasis (29), with anorectic, antiobesity, and insulin-sensitizing properties (30). In sheep and humans, plasma leptin concentrations are positively associated with body fatness and nutritional status (31).…”

Section: Discussionmentioning

confidence: 99%

“…Serum leptin concentration has been found in humans to be a biomarker for components of the metabolic syndrome in both lean and obese subjects (32). In long-standing type 2 diabetics, decreased leptin response to glucocorticoids was associated with inability to augment insulin secretion during glucocorticoid treatment, suggesting that deranged regulation of leptin may contribute to the obesity and insulin resistance seen in type 2 diabetes (30).…”

Section: Discussionmentioning

confidence: 99%

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

et al. 2011

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Periconceptional undernutrition and twin conception alter intrauterine growth and metabolism and are associated with later adverse metabolic outcomes. The contribution of postnatal growth to these outcomes is less well defined. We investigated whether maternal periconceptional undernutrition or twin conception altered postnatal growth regulation in ways that could lead to metabolic disease. Single and twin offspring of ewes undernourished (UN) from 61 d before until 30 d after mating, fed to achieve and maintain 10 -15% weight loss (UN), were compared with offspring of maintenance-fed controls (N). At 2 h and 1, 6, and 12 wk after birth, lambs were weighed and plasma hormone and metabolite concentrations analyzed. Milk intake, measured by deuterium oxide dilution, was inversely related to birth weight only in N singles, although twins had the greatest postnatal growth velocity. Positive associations were seen between milk intake, growth velocity, and leptin concentrations in N, but not UN, offspring. We conclude that periconceptional undernutrition alters the relationships between regulators of postnatal growth, including nutrient intake and key hormonal axes, in both singles and twins without affecting size at birth or postnatal growth velocity. Dissociation of growth from its key regulators is one possible mechanism underlying adverse metabolic outcomes after periconceptional undernutrition. (Pediatr Res 70: 261-266, 2011)

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“…Furthermore, leptin in BC, which works in concert with IGF-1, could be beneficial to people with elevated cholesterol and TG levels, because it is linked to fat breakdown in muscle. Interestingly, Type 2 diabetic patients were shown to have significantly lower leptin levels compared to nondiabetic subjects after controlling for age and percent body fat [14,15].…”

Section: Introductionmentioning

confidence: 98%

Health-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones

Kim

Jung

Choi

et al. 2009

The Journal of Nutritional Biochemistry

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Impaired leptin response to glucocorticoid as a chronic complication of diabetes

Cited by 14 publications

References 34 publications

Leptin Response to Glucocorticoid Occurs at Physiological Doses and Is Abolished by Fasting

Leptin Response to Glucocorticoid Occurs at Physiological Doses and Is Abolished by Fasting

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

Health-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones

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