Impaired lesion detectability on gadoxetic acid-enhanced MR imaging in indocyanine green excretory defect: case series of three patients

Masuoka, Sota; Nasu, Katsuhiro; Takahashi, Hiroaki; Kitao, Azusa; Sakai, Masafumi; Ishiguro, Toshitaka; Minami, Manabu

doi:10.1007/s11604-020-00991-9

Cited by 4 publications

(9 citation statements)

References 20 publications

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“…An increase in its amount results in increased ICG elimination (Fig- 2C). A previous study has shown that ICG uptake into the liver correlates with the expression of OATP1B3 (Masuoka et al, 2020). Whereas some studies quantified the OATP1B3 amount in Human liver samples (Burt et al, 2016;Peng et al, 2015;Prasad et al, 2014) to our knowledge no data reporting OATP1B3 amount and systemic ICG parameters exists.…”

Section: Discussionmentioning

confidence: 94%

“…Although OATP1B3 expression were significantly lower in the heterozygote than in the wild-type, the ICG-R15 results were comparable (Anzai et al, 2020), suggesting that some compensation is possible. Subjects with markedly poor ICG clearance but without severe liver disease are diagnosed with constitutional ICG excretory defect (Anzai et al, 2020;Namihisa et al, 1981) and lack of OATP1B3 expression has been confirmed in these subjects by immunohistochemistry (Kagawa et al, 2017;Masuoka et al, 2020). The incidence of ICG excretory defect is 0.007% in the Japanese population (Masuoka et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Subjects with markedly poor ICG clearance but without severe liver disease are diagnosed with constitutional ICG excretory defect (Anzai et al, 2020;Namihisa et al, 1981) and lack of OATP1B3 expression has been confirmed in these subjects by immunohistochemistry (Kagawa et al, 2017;Masuoka et al, 2020). The incidence of ICG excretory defect is 0.007% in the Japanese population (Masuoka et al, 2020). Anzai et al emphasized the importance of investigating the effect of the SLCO1B3 genotype on ICG clearance in cirrhotic patients in the future (Anzai et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Physiologically based modeling of the effect of physiological and anthropometric variability on indocyanine green based liver function tests

Köller

Grzegorzewski

König

2021

Preprint

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Accurate evaluation of liver function is a central task in hepatology. Dynamic liver function tests (DLFT) based on the time-dependent elimination of a test substance provide an important tool for such a functional assessment. These tests are used in the diagnosis and monitoring of liver disease as well as in the planning of hepatobiliary surgery. A key challenge in the evaluation of liver function with DLFTs is the large inter-individual variability. Indocyanine green (ICG) is a widely applied test compound used for the evaluation of liver function. After an intravenous administration, pharmacokinetic (PK) parameters are calculated from the plasma disappearance curve of ICG which provide an estimate of liver function. The hepatic elimination of ICG is affected by physiological factors such as hepatic blood flow or binding of ICG to plasma proteins, anthropometric factors such as body weight, age, and sex, or the protein amount of the organic anion-transporting polypeptide 1B3 (OATP1B3) mediating the hepatic uptake of ICG. Being able to account for and better understand these various sources of inter-individual variability would allow to improve the power of ICG based DLFTs and move towards an individualized evaluation of liver function. Within this work we systematically analyzed the effect of various factors on ICG elimination by the means of computational modeling. For the analysis, a recently developed and validated physiologically based pharmacokinetics (PBPK) model of ICG distribution and hepatic elimination was utilized. Key results are (i) a systematic analysis of the variability in ICG elimination due to hepatic blood flow, cardiac output, OATP1B3 abundance, liver volume, body weight and plasma bilirubin level; (ii) the evaluation of the inter-individual variability in ICG elimination via a large in silico cohort of n=100000 subjects based on the NHANES cohort with special focus on stratification by age, sex, and body weight; (iii) the evaluation of the effect of various degrees of cirrhosis on variability in ICG elimination. The presented results are an important step towards individualizing liver function tests by elucidating the effects of confounding physiological and anthropometric parameters in the evaluation of liver function via ICG.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Physiologically based modeling of the effect of physiological and anthropometric variability on indocyanine green based liver function tests

Köller

Grzegorzewski

König

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…An increase in its amount results in increased ICG elimination (Figure 2C). A previous study has shown that ICG uptake into the liver correlates with the expression of OATP1B3 (Masuoka et al, 2020). Whereas, some studies quantified the OATP1B3 amount in Human liver samples (Prasad et al, 2014;Peng et al, 2015;Burt et al, 2016) to our knowledge no data reporting OATP1B3 amount and systemic ICG parameters exists.…”

Section: Discussionmentioning

confidence: 95%

“…Although OATP1B3 expression were significantly lower in the heterozygote than in the wild-type, the ICG-R15 results were comparable (Anzai et al, 2020), suggesting that some compensation is possible. Subjects with markedly poor ICG clearance but without severe liver disease are diagnosed with constitutional ICG excretory defect (Namihisa et al, 1981;Anzai et al, 2020) and lack of OATP1B3 expression has been confirmed in these subjects by immunohistochemistry (Kagawa et al, 2017;Masuoka et al, 2020). The incidence of ICG excretory defect is 0.007% in the Japanese population (Masuoka et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Preoperative indocyanine green (ICG) clearance test: Can we really trust it to predict post hepatectomy liver failure? A systematic review of the literature and meta-analysis of diagnostic test accuracy

Granieri

Bracchetti

Kersik

et al. 2022

Photodiagnosis and Photodynamic Therapy

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Impaired lesion detectability on gadoxetic acid-enhanced MR imaging in indocyanine green excretory defect: case series of three patients

Cited by 4 publications

References 20 publications

Physiologically based modeling of the effect of physiological and anthropometric variability on indocyanine green based liver function tests

Physiologically based modeling of the effect of physiological and anthropometric variability on indocyanine green based liver function tests

Data_Sheet_1.PDF

Preoperative indocyanine green (ICG) clearance test: Can we really trust it to predict post hepatectomy liver failure? A systematic review of the literature and meta-analysis of diagnostic test accuracy

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