Impaired Mitochondrial Function and Reduced Energy Cost as a Result of Muscle Damage

Fouré, Alexandre; Wegrzyk, Jennifer; Fur, Yann Le; Mattei, Jean‐Pierre; Boudinet, Hélène; Vilmen, Christophe; Bendahan, David; Gondin, Julien

doi:10.1249/mss.0000000000000523

Cited by 18 publications

(19 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For larger muscle alterations, which have been reported in two studies [ 32 , 35 ], no significant effect of BCAAs supplementation has been disclosed. In these latter studies, the physiological benefits commonly linked to BCAAs supplementation—i.e., promotion of muscle-protein synthesis, reduction of protein oxidation, mitochondrial biogenesis and scavenging of reactive oxygen species—could not overcome the large alterations of muscle structural organization and/or muscle metabolism previously described [ 25 , 26 , 28 , 55 , 56 ]. However, muscle energetics impairment [ 57 ] and structural alterations [ 58 , 59 , 60 ] associated with low-to-moderate extent of muscle damage could be alleviated by a specific BCAAs supplementation strategy.…”

Section: Discussionmentioning

confidence: 96%

“…Exercise-induced muscle damage (EIMD) has been primarily associated with mechanical strain [ 21 , 22 ] and the subsequent inflammation processes [ 23 ]. On that basis, it has been considered that diminished muscle-protein breakdown during exercise [ 24 ] and the scavenging of reactive oxygen species [ 7 ] could alleviate structural and metabolic alterations observed after EIMD [ 25 , 26 ]. In addition, the anabolic effect associated with BCAAs consumption and especially leucine [ 9 , 27 ] has been considered a potential promoter of the repair process of altered muscle tissues in part composed of proteins.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is Branched-Chain Amino Acids Supplementation an Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic Review

Fouré

Bendahan

2017

Nutrients

Self Cite

View full text Add to dashboard Cite

Amino acids and more precisely, branched-chain amino acids (BCAAs), are usually consumed as nutritional supplements by many athletes and people involved in regular and moderate physical activities regardless of their practice level. BCAAs have been initially shown to increase muscle mass and have also been implicated in the limitation of structural and metabolic alterations associated with exercise damage. This systematic review provides a comprehensive analysis of the literature regarding the beneficial effects of BCAAs supplementation within the context of exercise-induced muscle damage or muscle injury. The potential benefit of a BCAAs supplementation was also analyzed according to the supplementation strategy—amount of BCAAs, frequency and duration of the supplementation—and the extent of muscle damage. The review protocol was registered prospectively with Prospective Register for Systematic Reviews (registration number CRD42017073006) and followed Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Literature search was performed from the date of commencement until August 2017 using four online databases (Medline, Cochrane library, Web of science and ScienceDirect). Original research articles: (i) written in English; (ii) describing experiments performed in Humans who received at least one oral BCAAs supplementation composed of leucine, isoleucine and valine mixture only as a nutritional strategy and (iii) reporting a follow-up of at least one day after exercise-induced muscle damage, were included in the systematic review analysis. Quality assessment was undertaken independently using the Quality Criteria Checklist for Primary Research. Changes in indirect markers of muscle damage were considered as primary outcome measures. Secondary outcome measures were the extent of change in indirect markers of muscle damage. In total, 11 studies were included in the analysis. A high heterogeneity was found regarding the different outcomes of these studies. The risk of bias was moderate considering the quality ratings were positive for six and neutral for three. Although a small number of studies were included, BCAAs supplementation can be efficacious on outcomes of exercise-induced muscle damage, as long as the extent of muscle damage was low-to-moderate, the supplementation strategy combined a high daily BCAAs intake (>200 mg kg−1 day−1) for a long period of time (>10 days); it was especially effective if taken prior to the damaging exercise.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Is Branched-Chain Amino Acids Supplementation an Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic Review

Fouré

Bendahan

2017

Nutrients

Self Cite

View full text Add to dashboard Cite

show abstract

“…Caspase 3, 6 or 7, Annexin V, TUNEL, Propidium iodide, cytochrome c ) [ 245 ] economic cooperation loss of differentiation undifferentiated cells tissue architecture (H&E) tissue-specific differentiation markers loss of cell function atrophy, metaplasia cell-type-specific functional assays expression assays of specialized cell function genes (RNA-Seq) increased resource accumulation large cells cell size (H&E, image/flow cytometry [ 246 , 247 ]) unrestrained metabolism increased mitochondria measure the number of mitochondria (e.g. TMRE or TMRM [ 248 ]) rate of ATP production [ 249 ] increased glucose use glucose uptake (PET scan [ 250 ] or stains for glucose transporters) increased expression of metabolic genes (e.g. RNA-Seq) inappropriate angiogenesis neoangiogenesis, abnormally dense microvessels angiogenesis (stains for endothelial cells and angiogenic factors [ 251 ]) destruction of tissue architecture loss of basal membrane basal membrane degradation (H&E, matrixmetalloprotease [ 252 ] stains) insufficient supporting infrastructure necrosis H&E, hypoxia assays (e.g.…”

Section: Discussionmentioning

confidence: 99%

Cancer across the tree of life: cooperation and cheating in multicellularity

Aktipis

Boddy

Jansen

et al. 2015

Phil. Trans. R. Soc. B

361

382

View full text Add to dashboard Cite

Multicellularity is characterized by cooperation among cells for the development, maintenance and reproduction of the multicellular organism. Cancer can be viewed as cheating within this cooperative multicellular system. Complex multicellularity, and the cooperation underlying it, has evolved independently multiple times. We review the existing literature on cancer and cancer-like phenomena across life, not only focusing on complex multicellularity but also reviewing cancer-like phenomena across the tree of life more broadly. We find that cancer is characterized by a breakdown of the central features of cooperation that characterize multicellularity, including cheating in proliferation inhibition, cell death, division of labour, resource allocation and extracellular environment maintenance (which we term the five foundations of multicellularity). Cheating on division of labour, exhibited by a lack of differentiation and disorganized cell masses, has been observed in all forms of multicellularity. This suggests that deregulation of differentiation is a fundamental and universal aspect of carcinogenesis that may be underappreciated in cancer biology. Understanding cancer as a breakdown of multicellular cooperation provides novel insights into cancer hallmarks and suggests a set of assays and biomarkers that can be applied across species and characterize the fundamental requirements for generating a cancer.

show abstract

“…We previously found that T 2 changes associated to NMES-induced muscle damage were partly due to the edema – i.e., characterized by the change in the volume of VL, VM and VI 22 -, the intramuscular membrane alterations – i.e., through the decrease in fractional anisotropy within the VL 22 - and decreased intracellular resting pH of the whole QF 45 . Edema, inflammation processes and change in intracellular pH can lead to change in water properties within the muscle and then influence the T 2 assessed by MRI 13 24 46 .…”

Section: Discussionmentioning

confidence: 99%

“…Stimulation intensity was gradually increased in order to reach the highest tolerated (considering the pain threshold) level of evoked force for each subject as previously described 22 47 . This type of NMES protocol has been already shown to induce a prolonged maximal voluntary contraction force loss, delayed onset muscle soreness, increased plasma creatine kinase activity 45 47 but more importantly heterogeneous T 2 changes across the four heads of the QF 22 .…”

Section: Methodsmentioning

confidence: 98%

Localization and quantification of intramuscular damage using statistical parametric mapping and skeletal muscle parcellation

Fouré

Troter

Guye

et al. 2015

Sci Rep

Self Cite

View full text Add to dashboard Cite

In the present study, we proposed an original and robust methodology which combines the spatial normalization of skeletal muscle images, the statistical parametric mapping (SPM) analysis and the use of a specific parcellation in order to accurately localize and quantify the extent of skeletal muscle damage within the four heads of the quadriceps femoris. T2 maps of thigh muscles were characterized before, two (D2) and four (D4) days after 40 maximal isometric electrically-evoked contractions in 25 healthy young males. On the basis of SPM analysis of coregistrated T2 maps, the alterations were similarly detected at D2 and D4 in the superficial and distal regions of the vastus medialis (VM) whereas the proportion of altered muscle was higher in deep muscle regions of the vastus lateralis at D4 (deep: 35 ± 25%, superficial: 23 ± 15%) as compared to D2 (deep: 18 ± 13%, superficial: 17 ± 13%). The present methodology used for the first time on skeletal muscle would be of utmost interest to detect subtle intramuscular alterations not only for the diagnosis of muscular diseases but also for assessing the efficacy of potential therapeutic interventions and clinical treatment strategies.

show abstract

Impaired Mitochondrial Function and Reduced Energy Cost as a Result of Muscle Damage

Abstract: Overall, NMES EIMD led to intramuscular acidosis in resting muscle and mitochondrial impairment in exercising muscle. Alterations of noncontractile processes and/or adaptive mechanisms to muscle damage might account for the decreased Ec during the dynamic exercise.

Cited by 18 publications

References 49 publications

Is Branched-Chain Amino Acids Supplementation an Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic Review

Is Branched-Chain Amino Acids Supplementation an Efficient Nutritional Strategy to Alleviate Skeletal Muscle Damage? A Systematic Review

Cancer across the tree of life: cooperation and cheating in multicellularity

Localization and quantification of intramuscular damage using statistical parametric mapping and skeletal muscle parcellation

Contact Info

Product

Resources

About