2012
DOI: 10.1007/s10911-012-9271-3
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Impaired Mitochondrial Metabolism and Mammary Carcinogenesis

Abstract: Mitochondrial oxidative metabolism plays a key role in meeting energetic demands of cells by oxidative phosphorylation (OxPhos). Here, we have briefly discussed (i) the dynamic relationship that exists among glycolysis, the tricarboxylic acid (TCA) cycle, and OxPhos; (ii) the evidence of impaired OxPhos (i.e. mitochondrial dysfunction) in breast cancer; (iii) the mechanisms by which mitochondrial dysfunction can predispose to cancer; and (iv) the effects of host and environmental factors that can negatively af… Show more

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Cited by 20 publications
(18 citation statements)
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References 176 publications
(221 reference statements)
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“…Thus, APIPOQ and HMGCS2 overexpression suggest that the manifestation of LCIS may reflect abnormal hormone and fatty acid levels in the breast tissues, impaired fatty acid oxidation, and mitochondrial dysfunction . Mitochondrial dysfunction can lead to inflammation, tumorigenesis, dysregulation of cell–cell adhesion, discohesive morphology, and invasion . These characteristics of mitochondrial dysregulation are supported by our differential gene expression analyses.…”
Section: Resultssupporting
confidence: 74%
“…Thus, APIPOQ and HMGCS2 overexpression suggest that the manifestation of LCIS may reflect abnormal hormone and fatty acid levels in the breast tissues, impaired fatty acid oxidation, and mitochondrial dysfunction . Mitochondrial dysfunction can lead to inflammation, tumorigenesis, dysregulation of cell–cell adhesion, discohesive morphology, and invasion . These characteristics of mitochondrial dysregulation are supported by our differential gene expression analyses.…”
Section: Resultssupporting
confidence: 74%
“…By contrast, cancer cells rely heavily on glycolysis to generate two ATPs per glucose molecule in the cytoplasm. Hence, cancer cells upregulate glucose transporters to increase glucose uptake into the cell and meet their energy needs [2527]. Otto Warburg was the first to observe these effects and postulate that respiration dysfunction in cancer cells prevents glucose oxidation via the TCA in mitochondria [10].…”
Section: Metabolic Differences Between Normal and Cancer Cellsmentioning
confidence: 99%
“…In addition to the direct DNA damage in tumor cells that are a result of chemotherapy agents such as anthracyclines, these drugs also interfere with mitochondrial function and ATP production which can have diverse effects [55] . Cardiomyocytes derive as much as 90% of ATP from mitochondrial oxidative phosphorylation, and thus, are extremely sensitive to the effects of anthracyclines.…”
Section: Makari-judson G Et Al Weight Gain Following Breast Cancer mentioning
confidence: 99%