Impaired movement sequencing in patients with Huntington's disease: A kinematic analysis

Phillips, James G.; Chiu, Ed; Bradshaw, John L.; Iansek, Robert

doi:10.1016/0028-3932(94)00114-5

Cited by 42 publications

(24 citation statements)

References 12 publications

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“…The data in the present study underscore the importance of basal ganglia circuits in the concatenation and parsing of action sequences, and thus their fundamental role in learning and organization of behavior. These findings may have important implications for understanding the neurological and psychiatric disorders where action chunking is affected, including Parkinson’s and Huntington’s diseases 11,12 , obsessive-compulsive behavior 40 , and speech disorders 41 .…”

Section: Discussionmentioning

confidence: 93%

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

2014

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Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known about how individual elements are concatenated into a behavioral sequence at the neural level. Using a task where mice learn rapid action sequences, we uncovered neuronal activity encoding entire sequences as single actions in basal ganglia circuits. Besides start/stop activity signaling sequence parsing, we found neurons displaying inhibited or sustained activity throughout the execution of an entire sequence. This sustained activity covaried with the rate of execution of individual sequence elements, consistent with motor concatenation. Direct and indirect pathways of basal ganglia were concomitantly active during sequence initiation, but behaved differently during sequence performance, revealing a more complex functional organization of these circuits than previously postulated. These results have important implications for understanding the functional organization of basal ganglia during the learning and execution of action sequences.

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Section: Discussionmentioning

confidence: 93%

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

2014

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“…As the model is currently defined, it is not possible to differentiate between internally generated and externally cued speech. Diseases of the basal ganglia, such as Parkinson's disease and Huntington's disease, are known to impair movement sequencing (Stem, Mayeux, Rosen, & Ilson, 1983;Georgiou eta!., 1994;Phillips, Chiu, Bradshaw, & Iansek, 1995;Rogers, Phillips, Bradshaw, Iansek, & Jones, 1998), and single-cell recordings indicate that cells in the basal ganglia in monkeys and rats code aspects of movement sequences (Kermadi & Joseph, 1995;Aldridge & Berridge, 1998). The basal ganglia are strongly interconnected to the frontal cortex through a set of segregated basal ganglia-thalan1o-cortical loops, including a loop focused on the SMA (DeLong & Wichman, 1993;Red grave, Prescott, & Gurney, 1999).…”

Section: Discussionmentioning

confidence: 99%

Neural modeling and imaging of the cortical interactions underlying syllable production

2006

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This paper describes a neural model of speech acquisition and production that accounts for a wide range of acoustic, kinematic, and neuroimaging data concerning the control of speech movements. The model is a neural network whose components correspond to regions of the cerebral cortex and cerebellum, including premotor, motor, auditory, and somatosensory cortical areas. Computer simulations of the model verify its ability to account for compensation to lip and jaw perturbations during speech. Specific anatomical locations of the model's components are estimated, and these estimates are used to simulate fMRI experiments of simple syllable production with and without jaw perturbations.2

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“…Individuals with HD appear to produce movements more slowly when the task requires sequencing of two discrete movements 4,7 or when the task involves progressive sequencing of successive movement parts, such as in handwriting. 19 In the present study, the movement sequencing involves transitioning between two distinct phases of a very welllearned movement pattern. Specifically, subjects must transition between a reach-to-grasp and a grasp-lift movement.…”

Section: Bradykinesiamentioning

confidence: 99%

Altered movement trajectories and force control during object transport in Huntington's disease

et al. 2001

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Individuals with Huntington's Disease (HD) have difficulty grasping and transporting objects, however, the extent to which specific impairments affect their performance is unknown. The present study examined the kinematics and force coordination during transport of an object in 12 subjects with HD and 12 age-matched controls. Subjects grasped an object between their thumb and index finger, transported it 25 cm forward, replaced and released it while their fingertip forces and the object's position were recorded. Five trials were performed with each of three weights (200 g, 400 g, and 800 g). While bradykinesia was evident in subjects with HD, this slowness was not consistently observed in all phases of the movement. The slowness of movement seen during the task appears to be due to impairments in sequencing and the movement strategies selected by the subjects. Compared to control subjects, subjects with HD produced highly curvilinear hand paths and more variable grip forces that were dependent on the weight of the object. Isometric force development and movement speed during transport were unaffected by the disease. The results suggest that prolonged task durations in subjects with HD are not necessarily due to slowness of movement, per se. These findings have clinical implications for understanding the task-specific nature of movement impairments in HD and developing effective intervention strategies.

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Impaired movement sequencing in patients with Huntington's disease: A kinematic analysis

Cited by 42 publications

References 12 publications

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

Neural modeling and imaging of the cortical interactions underlying syllable production

Altered movement trajectories and force control during object transport in Huntington's disease

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