Impaired Natural Killer Cell Lysis in Breast Cancer Patients with High Levels of Psychological Stress is Associated with Altered Expression of Killer Immunoglobin-Like Receptors

Varker, Kimberly A.; Terrell, Catherine E.; Welt, Marilyn; Suleiman, Samer; Thornton, Lisa M.; Andersen, Barbara L.; Carson, William E.

doi:10.1016/j.jss.2006.08.037

Cited by 37 publications

(34 citation statements)

References 45 publications

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“…132 Although psychological stress in female breast cancer patients impairs NK cell activity, it does not alter lymphokine-activated killer activity. 133 Similarly, in the Nurses' Health Study, the relative breast cancer risks were the same for women reporting passive jobs and those reporting high-strain jobs. 134 The connection between the duration of shift work and the increased risk of breast cancer needs to be fully explored, as increased breast cancer risk has been noted in those working shifts for just half a year as well as in those working for >30 years.…”

Section: Shift Work and Cancermentioning

confidence: 93%

Sleep and Health Consequences of Shift Work in Women

Chung

Wolf

Shapiro

2009

Journal of Women's Health

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Women constitute about half the work force, and women shift workers warrant special attention given the different physiological needs of women, their reproductive status, and the added burden of family responsibilities. There is increasing evidence that women have greater difficulty adjusting to shift work compared to their male counterparts and that sleep problems may in large part account for this difficulty. The purpose of this article is to review the existing literature to highlight the differential negative impact of shift work on sleep and other health issues in women and as part of a needs assessment to promote research in female shift workers by developing and prioritizing research questions in this field. The literature suggests that women shift workers report poor sleep quality and experience reproductive disturbances, an increased risk of breast cancer, and a greater risk of metabolic and cardiovascular disorders.

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Section: Shift Work and Cancermentioning

confidence: 93%

Sleep and Health Consequences of Shift Work in Women

Chung

Wolf

Shapiro

2009

Journal of Women's Health

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“…In individuals with stage II and III breast cancer before a surgery intervention, high stress levels as assessed with a self-reported questionnaire (i.e., Impact of Event Scale) predicted subsequent reduced lysis potential by natural killer (NK) cells, as well as diminished response of NK cells to IFN gamma and decreased proliferative response of peripheral blood lymphocytes to a monoclonal antibody stimulating the T-cell receptor 118 . A subsequent small follow-up study involving a subset of patients demonstrated that dysfunctional alterations in NK-cells activity in association with high levels of psychological stress may be long-lasting, although the relevance of stress-induced detrimental effects on cancer survival and recurrence is still unclear 119 .…”

Section: Stress As a Modulator Of Immune Response In Depression And Cmentioning

confidence: 99%

Depression in cancer: The many biobehavioral pathways driving tumor progression

Bortolato

Hyphantis

Valpione

et al. 2017

Cancer Treatment Reviews

261

179

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Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote:(1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitary-adrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioural pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.

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“…Both surgical and psychological stress are known to affect negatively a number of immune parameters (1)(2)(3)(4)(5)(6)(7). Surgical stress evokes a potent local and systemic inflammatory response with transient increases in proinflammatory cytokines interleukin (IL)-1␤, IL-6, IL-8, and tumor necrosis factor (TNF)-␣ (2), as well as a generalized state of immunodepression (1,3,4).…”

Section: Introductionmentioning

confidence: 99%