Impaired Neurocognitive Performance in Children after Liver Transplantation

Abstract

Objectives To assess longitudinal neurocognitive development after liver transplantation and evaluate factors associated with neurocognitive performance.Study design Data from neurocognitive testing of 65 children (aged <18 years) who underwent liver transplantation at Oslo University Hospital between 1995 and 2018 were collected from the testing program after transplantation. The parent-reported version of the Behavior Rating Inventory of Executive Function was used to assess executive function.Results A total of 104 neurocognitive tests were conducted on 65 patients. At the first test, conducted at a median of 4.1 years (IQR, 1.5-5.3 years) after transplantation and at a median age of 6.7 years (IQR, 5.4-10.5 years), the mean full-scale IQ (FSIQ) was 91.7 AE 14, and the mean verbal comprehension index was 92.0 AE 14.5. In the 30 patients tested more than once, there was no significant difference in FSIQ between the first test at a median age of 5.8 years (IQR, 5.2-8.5 years) and the last test at a median age of 10.8 years (IQR, 9.8-12.9 years) (87.4 AE 12.9 vs 88.5 AE 13.2; P = .58). Compared with the patients who underwent transplantation a age >1 year (n = 35), those who did so at age <1 year (n = 30) had a lower FSIQ (87.1 AE 12.6 vs 96.6 AE 13.8; P = .005) and lower verbal comprehension index (87.3 AE 13.8 vs 95.4 AE 13.0; P = .020). Age at transplantation (P = .005; adjusted for cholestasis: P = .038) and transfusion of >80 mL/kg (P = .004; adjusted for age at transplantation: P = .046) were associated with FSIQ.Conclusions Young age at transplantation and large blood transfusions during transplantation are risk factors for poor neurocognitive performance later in life. Children who undergo transplantation before 1 year of age have significantly lower neurocognitive performance compared with those who do so later in childhood. Cognitive performance did not improve over time after transplantation.

Cognitive function of children with biliary atresia after primary living donor liver transplantation

“…Although the highest prevalence of language delay is reported at ages 2-3 years, in our study, 19.29% (11/57) of the children with BA-pLDLT showed a delay and 29.82%(17/57) had borderline delay in this domain , which is higher than the incidence of language delay of 15% reported in previous studies [19]. This nding is consistent with those of Zhu et al [11] and Ostensen et al [20]. Early language delays in children not only impact their language comprehension and expression but also have long-term effects on their learning, communication, and social relationships [21].…”

Cognitive function of children with biliary atresia after primary living donor liver transplantation

“…Although the highest prevalence of language delay is reported at ages 2 ~ 3 years, in our study, 19.29% (11/57) of the children with BA-pLDLT showed a delay and 29.82%(17/57) had borderline delay in this domain, which is higher than the incidence of language delay of 15% reported in previous studies [19]. This finding is consistent with those of Zhu et al [12] and Ostensen et al [20]. Early language delays in children not only impact their language comprehension and expression but also have long-term effects on their learning, communication, and social relationships [21].…”

Prognosis of Children Undergoing Liver Transplantation: A 30-Year European Study

“…6 Our own analysis of present data in children <1 year of age show slightly worse outcomes as compared with children aged 1 to 12 years. A recent study from Norway 14 reveals young age at PLT as a risk factor for poor neurocognitive function in later life. Altogether, the optimal timing of transplantation in its complexity remains controversial.…”