2001
DOI: 10.1152/ajpheart.2001.281.3.h1304
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Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats

Abstract: This study determined alterations to nitric oxide (NO)-dependent dilation of skeletal muscle arterioles from obese (OZR) versus lean Zucker rats (LZR). In situ cremaster muscle arterioles from both groups were viewed via television microscopy, and vessel dilation was measured with a video micrometer. Arteriolar dilation to acetylcholine and sodium nitroprusside was reduced in OZR versus LZR, although dilation to aprikalim was unaltered. NO-dependent flow-induced arteriolar dilation (via parallel microvessel oc… Show more

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Cited by 143 publications
(185 citation statements)
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“…Endothelium-dependent vasodilation was assessed using the isolated gracilis artery preparation, as described previously (14). Briefly, gracilis arteries were isolated from the hindlimb of LZR and OZR, mounted between two glass pipettes, and pressurized at 60 mmHg.…”
Section: Methodsmentioning
confidence: 99%
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“…Endothelium-dependent vasodilation was assessed using the isolated gracilis artery preparation, as described previously (14). Briefly, gracilis arteries were isolated from the hindlimb of LZR and OZR, mounted between two glass pipettes, and pressurized at 60 mmHg.…”
Section: Methodsmentioning
confidence: 99%
“…Vessels generated 15-20% baseline tone, which was further increased with 10 Ϫ6 M phenylephrine to a final diameter that was 50% of passive diameter. Endothelium-dependent vasodilation to acetylcholine is ϳ100% sensitive to nitro-L-arginine methyl ester in this preparation (14) and was used as an index of NO-mediated dilation. Serial doses of acetylcholine from 10 Ϫ7 to 3 ϫ 10 Ϫ5 M were applied to the bath, and diameter was recorded during steady-state conditions.…”
Section: Methodsmentioning
confidence: 99%
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“…In animal models of diabetes, increased oxidative excess also led to endothelial dysfunction (60,61). ROS seem also to be involved in the mediation of endothelial injury leading to programmed cell death or apoptosis and to a form of apoptosis characterized by detachment of endothelial cells called anoikis (62).…”
Section: Oxidative Excessmentioning
confidence: 99%