Impaired option generation underpins deficient reasoning in Parkinson’s disease patients with apathy

Mole, J; Josephs, Laurie; Prangnell, Simon

doi:10.1080/23279095.2020.1712400

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2021

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“…Furthermore, PD affects various executive functions. For example, cognitive dysfunctions are observed in response inhibition (Baglio et al., 2011; Picazio et al., 2018), task‐switching (Langston & Virmani, 2018), working memory (Moustafa et al., 2013), reasoning (Mole et al., 2020), language (Magee et al., 2019), and others. In addition, some patients present with risks of psychiatric disorders such as depression (Schrag et al., 2007), anxiety (Rutten et al., 2017), impulsivity (Kubera et al., 2019), and apathy (Costa et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Stopwatch training improves cognitive functions in patients with Parkinson's disease

Honma

Murakami

Yabe³

et al. 2021

J of Neuroscience Research

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Estimation of the passage of time is an important function to prepare for and predict an action to or smoothly communicate with others. The sensory systems corresponding to time perception remain unknown; consequently, the processing of time perception is considered to be extremely complex and thought to be accomplished by a wide neural network including regions such as the prefrontal cortex, striatum, hippocampus, nucleus subthalamicus, and cerebellum (Buhusi & Meck, 2005; Shi et al., 2013). Distortion of time perception has been reported in a number of diseases, including epilepsy (Drane et al., 1999), depression (Thones & Oberfeld, 2015),

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