Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction <i>via</i> Oxidative Stress

Piao, Lingjuan; Dorotea, Debra; Jiang, Songling; Koh, Eun Hee; Oh, Goo Taeg; Ha, Hunjoo

doi:10.1089/ars.2018.7614

Cited by 14 publications

(16 citation statements)

References 41 publications

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“…Eight-week-old male mice were used in this study. Mice were fed with either normal diet (ND, D12450, 10 kcal% fat, Research Diets, Inc. New Brunswick, NJ, USA) or HFD (D12492, 60 kcal% fat, Research Diets, Inc.) for 12 weeks ( n = 7 for each group) [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Jiang

Piao

et al. 2021

Biomolecules

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Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation studies in humans are related to the heterogeneity of the study population. The fact that irisin is not only a myokine but also an adipokine leads to the further complexity of the role of irisin in metabolic regulation. In this study, we examined the regulation of FNDC5 expression and irisin in circulation in both type 1 and type 2 diabetic mice, and their potential relationships with metabolic parameters. In streptozotocin (STZ)-induced type 1 diabetic mice, high-fat diet (HFD)-induced obese mice and db/db mice, the circulating irisin as well as FNDC5 gene expression in subcutaneous fat was downregulated. Muscle FNDC5 expression was only significantly lower in STZ mice, and epididymal fat FNDC5 expression was unaltered. It is interesting to note that plasma irisin levels correlated positively with subcutaneous fat FNDC5 expression, but not epididymal fat or muscle. Moreover, both irisin levels and subcutaneous fat FNDC5 correlated negatively with markers of insulin resistance. These results suggest a regulatory role for subcutaneous fat-derived FNDC5/irisin in metabolic disease.

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Section: Methodsmentioning

confidence: 99%

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Jiang

Piao

et al. 2021

Biomolecules

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“…Several studies have reported excessive cellular ROS production upon peroxisomal dysfunction. For example, impaired peroxisomal import by knocking down Pex5 in adipocytes significantly elevated cytosolic ROS production [ 76 ]. Likewise, peroxisome disfunction associated with Pex13 [ 77 ] or Pex11b [ 78 ] deficiency led to higher ROS production in lung fibroblasts and neurons, respectively.…”

Section: Cellular Responses To Peroxisomal Dysfunctionmentioning

confidence: 99%

“…As peroxisomal activities decline with age [ 170 ], it has been suggested that peroxisomal dysfunctions might be associated with the pathogenesis of age-related neurodegenerative disease, including Alzheimer’s disease [ 171 ], Parkinson’s disease [ 172 ], and amyotrophic lateral sclerosis [ 173 ]), as well as age-related metabolic disease, such as cardiovascular disease [ 174 ], obesity [ 76 ], diabetes [ 175 ], and nonalcoholic liver disease [ 176 ]. These age-related pathologies are likely due to increased oxidative stress [ 177 , 178 ] and decreased plasmalogen synthesis [ 179 ].…”

Section: Peroxisomal Dysfunction In Aging and Aging-related Diseasesmentioning

confidence: 99%

“…As life expectancy increases, the prevalence of obesity has also risen steadily among the elderly [ 199 ]. A recent study demonstrated that peroxisomes play an important role in adipose dysfunction associated with obesity [ 76 ]. The authors found that obese mice exhibited downregulation of peroxisomal genes in white adipose tissue, and the knockdown of Pex5 increased ROS levels and inflammation in adipocytes.…”

Section: Peroxisomal Dysfunction In Aging and Aging-related Diseasesmentioning

confidence: 99%

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Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

Kim

Bai

2022

Antioxidants

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Peroxisomes are key regulators of cellular and metabolic homeostasis. These organelles play important roles in redox metabolism, the oxidation of very-long-chain fatty acids (VLCFAs), and the biosynthesis of ether phospholipids. Given the essential role of peroxisomes in cellular homeostasis, peroxisomal dysfunction has been linked to various pathological conditions, tissue functional decline, and aging. In the past few decades, a variety of cellular signaling and metabolic changes have been reported to be associated with defective peroxisomes, suggesting that many cellular processes and functions depend on peroxisomes. Peroxisomes communicate with other subcellular organelles, such as the nucleus, mitochondria, endoplasmic reticulum (ER), and lysosomes. These inter-organelle communications are highly linked to the key mechanisms by which cells surveil defective peroxisomes and mount adaptive responses to protect them from damages. In this review, we highlight the major cellular changes that accompany peroxisomal dysfunction and peroxisomal inter-organelle communication through membrane contact sites, metabolic signaling, and retrograde signaling. We also discuss the age-related decline of peroxisomal protein import and its role in animal aging and age-related diseases. Unlike other organelle stress response pathways, such as the unfolded protein response (UPR) in the ER and mitochondria, the cellular signaling pathways that mediate stress responses to malfunctioning peroxisomes have not been systematically studied and investigated. Here, we coin these signaling pathways as “peroxisomal stress response pathways”. Understanding peroxisomal stress response pathways and how peroxisomes communicate with other organelles are important and emerging areas of peroxisome research.

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“…Attenuating ROS emission, either by treatment of antioxidant or by genetically overexpression of catalase, has been shown to improve obesity-induced metabolic disorders (70,71). Catalaseknockout mice exhibited more weight gain and higher fat mass under either normal chow or high-fat diet feeding conditions than control mice (72,73). This phenotype of catalaseknockout mice can be attenuated by concomitant treatment with antioxidant, melatonin or N-acetyl cysteine (73).…”

Section: Antioxidant Systems In Adipose Tissuementioning

confidence: 99%

The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity

Zhou

Xia

2021

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) rank the leading cause of morbidity and mortality globally. Obesity and its related metabolic syndrome are well-established risk factors for CVDs. Therefore, understanding the pathophysiological role of adipose tissues is of great importance in maintaining cardiovascular health. Oxidative stress, characterized by excessive formation of reactive oxygen species, is a common cellular stress shared by obesity and CVDs. While plenty of literatures have illustrated the vascular oxidative stress, very few have discussed the impact of oxidative stress in adipose tissues. Adipose tissues can communicate with vascular systems, in an endocrine and paracrine manner, through secreting several adipocytokines, which is largely dysregulated in obesity. The aim of this review is to summarize current understanding of the relationship between oxidative stress in obesity and vascular endothelial dysfunction. In this review, we briefly describe the possible causes of oxidative stress in obesity, and the impact of obesity-induced oxidative stress on adipose tissue function. We also summarize the crosstalk between adipose tissue and vasculature mediated by adipocytokines in vascular oxidative stress. In addition, we highlight the potential target mediating adipose tissue oxidative stress.

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Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction via Oxidative Stress

Cited by 14 publications

References 41 publications

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity

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