Impaired prefrontal–amygdala effective connectivity is responsible for the dysfunction of emotion process in major depressive disorder: A dynamic causal modeling study on MEG

Lü, Qing; Li, Haoran; Luo, Guoping; Wang, Yi; Tang, Hao; Han, Liang; Yao, Zhijian

doi:10.1016/j.neulet.2012.06.058

Cited by 120 publications

(77 citation statements)

References 36 publications

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“…This may suggest that patients were less skilled in executive functioning as supported by working memory33 and Go/Nogo studies34. With respect to emotion processing, researchers have documented impaired prefrontal-limbic circuits in patients with MDD35. Compatible with these results, we found decreased degree centrality in the prefrontal cortex and limbic areas.…”

Section: Discussionsupporting

confidence: 80%

Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder

Luo

Deng

Qin

et al. 2015

Sci Rep

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Major depressive disorder is associated with aberrant topological organizations of brain networks. However, whether this aberrance is shown in broader frequency bands or in a specific frequency band remains unknown. Fifty patients and fifty gender, age and education matched normal controls underwent resting state functional magnetic resonance imaging. Frequency dependent topological measures based on graph theory were calculated from wavelet decomposed resting state functional brain signals. In the specific frequency band of 0.03–0.06 14Hz, the clustering coefficient and the global efficiency were reduced while the characteristic path length was increased. Furthermore, patients showed aberrant nodal centralities in the default mode network, executive network and occipital network. Network based statistical analysis revealed system-wise topological alterations in these networks. The finding provides the first systematic evidence that depression is associated with frequency specific global and local topological disruptions and highlights the importance of frequency information in investigating major depressive disorders.

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Section: Discussionsupporting

confidence: 80%

Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder

Luo

Deng

Qin

et al. 2015

Sci Rep

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“…These results suggest that depressive patients or patients with an anxiety disorder do not only have impairments in their emotional responses but also in the cognitive and attentional regulation of these induced responses. Functional connectivity studies revealed that impairments in the down-regulation of the amygdalae responses from the prefrontal cortex could be causal for affective disorders [72-74]. Interestingly [72], was able to show this in females with a major depressive disorder while they where processing negative stimuli as well as positive stimuli.…”

Section: Discussionmentioning

confidence: 99%

Does the amygdala response correlate with the personality trait ‘harm avoidance’ while evaluating emotional stimuli explicitly?

Schuerbeek

Baeken

Luypaert

et al. 2014

Behavioral and Brain Functions

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BackgroundThe affective personality trait ‘harm avoidance’ (HA) from Cloninger’s psychobiological personality model determines how an individual deals with emotional stimuli. Emotional stimuli are processed by a neural network that include the left and right amygdalae as important key nodes. Explicit, implicit and passive processing of affective stimuli are known to activate the amygdalae differently reflecting differences in attention, level of detailed analysis of the stimuli and the cognitive control needed to perform the required task. Previous studies revealed that implicit processing or passive viewing of affective stimuli, induce a left amygdala response that correlates with HA. In this new study we have tried to extend these findings to the situation in which the subjects were required to explicitly process emotional stimuli.MethodsA group of healthy female participants was asked to rate the valence of positive and negative stimuli while undergoing fMRI. Afterwards the neural responses of the participants to the positive and to the negative stimuli were separately correlated to their HA scores and compared between the low and high HA participants.ResultsBoth analyses revealed increased neural activity in the left laterobasal (LB) amygdala of the high HA participants while they were rating the positive and the negative stimuli.ConclusionsOur results indicate that the left amygdala response to explicit processing of affective stimuli does correlate with HA.

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“…For example, David et al (2011) explored the brain circuitry deep in subcortical sources by introducing a definition of hidden sources, which clearly confirmed the validity of exploring deep subcortical source via MEG. Thereafter, reconstructed MEG signals were utilized to explore the impaired prefrontal-amygdala connectivity (Lu et al, 2012) and the lateralized dynamic connectivity of the amygdale to ACC (Lu et al, 2013) in patients with depression. Hereto, we should suggest the possibility and validity of exploring deep subcortical regions via MEG and its application can be enlarged along with the development of source reconstruction methodologies.…”

Section: Discussionmentioning

confidence: 99%

Predicting depression based on dynamic regional connectivity: A windowed Granger causality analysis of MEG recordings

Lü

Chu

et al. 2013

Brain Research

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Impaired prefrontal–amygdala effective connectivity is responsible for the dysfunction of emotion process in major depressive disorder: A dynamic causal modeling study on MEG

Cited by 120 publications

References 36 publications

Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder

Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder

Does the amygdala response correlate with the personality trait ‘harm avoidance’ while evaluating emotional stimuli explicitly?

Predicting depression based on dynamic regional connectivity: A windowed Granger causality analysis of MEG recordings

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