Impaired quality of life after chikungunya virus infection: a 2-year follow-up study

Couturier, Élisabeth; Guillemin, Françis; Mura, Marie; Léon, Lucie; Virion, Jean-Marc; Letort, Marie-José; Valk, Henriette de; Simon, Fabrice; Vaillant, V.

doi:10.1093/rheumatology/kes015

Cited by 153 publications

(155 citation statements)

References 22 publications

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“…However, unlike dengue, a characteristic feature of CHIKV disease is recurring musculoskeletal disease primarily affecting the peripheral joints that can persist for months to years after acute infection (7)(8)(9)(10). CHIKV disease is often self-limiting and has a low fatality rate (~0.1%) (11), but manifestations of CHIKV infection that lead to acute and chronic disability have considerable implications, including a substantial impact on quality of life for infected patients as well as considerable economic and community consequences (7,9,12).…”

Section: Ecology and Epidemiologymentioning

confidence: 99%

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

Silva¹,

Dermody²

2017

Journal of Clinical Investigation

326

338

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Section: Ecology and Epidemiologymentioning

confidence: 99%

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

Silva¹,

Dermody²

2017

Journal of Clinical Investigation

326

338

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“…Other symptoms of CHIKV infection include a rapid onset of high fever, headache, skin rash, and myalgia. Most of the symptoms normally resolve in weeks but can develop into chronic joint problems and, in rare cases, even mortality (6)(7)(8). There is currently no CHIKV-specific treatment and no licensed vaccine that can prevent CHIKV infection (9).…”

Section: Hikungunya Virus (Chikv) Is An Alphavirus Of the Familymentioning

confidence: 99%

Prime-Boost Immunization Strategies against Chikungunya Virus

Holzmann

Lum

Kümmerer

et al. 2014

J Virol

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Chikungunya virus (CHIKV) is a reemerging mosquito-borne alphavirus that causes debilitating arthralgia in humans. Here we describe the development and testing of novel DNA replicon and protein CHIKV vaccine candidates and evaluate their abilities to induce antigen-specific immune responses against CHIKV. We also describe homologous and heterologous prime-boost immunization strategies using novel and previously developed CHIKV vaccine candidates. Immunogenicity and efficacy were studied in a mouse model of CHIKV infection and showed that the DNA replicon and protein antigen were potent vaccine candidates, particularly when used for priming and boosting, respectively. Several prime-boost immunization strategies eliciting unmatched humoral and cellular immune responses were identified. Further characterization by antibody epitope mapping revealed differences in the qualitative immune responses induced by the different vaccine candidates and immunization strategies. Most vaccine modalities resulted in complete protection against wild-type CHIKV infection; however, we did identify circumstances under which certain immunization regimens may lead to enhancement of inflammation upon challenge. These results should help guide the design of CHIKV vaccine studies and will form the basis for further preclinical and clinical evaluation of these vaccine candidates. IMPORTANCE As of today, there is no licensed vaccine to prevent CHIKV infection. In considering potential new vaccine candidates, a vaccinethat could raise long-term protective immunity after a single immunization would be preferable. While humoral immunity seems to be central for protection against CHIKV infection, we do not yet fully understand the correlates of protection. Therefore, in the absence of a functional vaccine, there is a need to evaluate a number of different candidates, assessing their merits when they are used either in a single immunization or in a homologous or heterologous prime-boost modality. Here we show that while single immunization with various vaccine candidates results in potent responses, combined approaches significantly enhance responses, suggesting that such approaches need to be considered in the further development of an efficacious CHIKV vaccine.

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“…fever, headache, myalgia, fatigue and polyarthalgia), although painful, resolve in a few days. The most prominent problem is the recurrent appearance of arthralgia that might compromise the quality of life of the affected individual (Couturier et al 2012, Schilte et al 2013. The chronic symptoms are due to the ability of the virus to replicate in joint tissues and muscle cells.…”

Section: Chikungunya Virusmentioning

confidence: 99%

Animal models in biological and biomedical research - experimental and ethical concerns

Andersen

Winter

2019

An. Acad. Bras. Ciênc.

148

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Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. In this review, we intend to give examples on how animals are used in the health research related to some major health problems in Brazil, as well as to stimulate discussion about the application of ethics in the use of animals in research and education, highlighting the role of National Council for the Control of Animal Experimentation (Conselho Nacional de Controle de Experimentação Animal -CONCEA) in these areas. In 2008, Brazil emerged into a new era of animal research regulation, with the promulgation of Law 11794, previously known as the Arouca Law, resulting in an increased focus, and rapid learning experience, on questions related to all aspects of animal experimentation. The law reinforces the idea that animal experiments must be based on ethical considerations and integritybased assumptions, and provides a regulatory framework to achieve this. This review describes the health research involving animals and the current Brazilian framework for regulating laboratory animal science, and hopes to help to improve the awareness of the scientific community of these ethical and legal rules.

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Impaired quality of life after chikungunya virus infection: a 2-year follow-up study

Abstract: Medical follow-up with special attention to comorbidity providing information on possible chronic symptoms and giving support for potential depression and anxiety are recommended.

Cited by 153 publications

References 22 publications

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

Prime-Boost Immunization Strategies against Chikungunya Virus

Animal models in biological and biomedical research - experimental and ethical concerns

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