Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region

Zola, Stuart M.; Squire, Larry R.; Teng, Edmond; Stefanacci, Lisa; Buffalo, Elizabeth A.; Clark, Robert E.

doi:10.1523/jneurosci.20-01-00451.2000

Cited by 422 publications

(393 citation statements)

References 50 publications

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“…This theory, then, explains the delay-dependent deficits seen by Zola et al [253] as reflecting a loss of contextual-memory. If we ask how an animal can solve the DNMS task, we see that both active memory and content-addressable-memory mechanisms would be helpful.…”

Section: Slipping Out Of Contextmentioning

confidence: 83%

“…By pooling across the groups, a population could be generated with 18 lesioned animals. These animals showed small but significant deficits even in the 15 s condition [253].…”

Section: Slipping Out Of Contextmentioning

confidence: 87%

“…And animal studies attempting to study recent declarative memory are inconsistent in their conclusions as to whether the hippocampus is involved in declarative memory or not [4,26,27 [4,26,27,32,45,70,113,119,133,135,137,253,257,258]. As with the water maze for spatial cognition, the DNMS task is a complex task that can be solved in a number of ways.…”

Section: Hmmentioning

confidence: 99%

“…In a recent study, Zola et al [253] performed a meta-analysis of their previous studies, including ischemic, radio-frequency, and ibotenic-acid lesions. These monkeys were all tested at 8 and 15 s, and 1, 10, and 40 min delays.…”

Section: Slipping Out Of Contextmentioning

confidence: 99%

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The hippocampal debate: are we asking the right questions?

Redish

2001

Behavioural Brain Research

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For years, the debate has been: 'Is the hippocampus the cognitive map?' or 'Is the hippocampus the core of memory?' These two hypotheses derived their original power from two key experiments-the cognitive map theory from the remarkable spatial correlates seen in recordings of hippocampal pyramidal cells and the memory theory from the profound amnesias seen in the patient H.M. Both of these key experiments have been reinterpreted over the years: hippocampal cells are correlated with much more than place and H.M. is missing much more than just his hippocampus. However, both theories are still debated today. The hippocampus clearly plays a role in both navigation and memory processing. The question that must be addressed is rather: 'What is the role played by the hippocampus in the navigation and memory systems?' By looking at the navigation system as a whole, one can identify the major role played by the hippocampus as correcting for accumulation errors that occur within idiothetic navigation systems. This is most clearly experimentally evident as reorientation when an animal is lost. Carrying this over to a more general process, this becomes a role of recalling a context, bridging a contextual gap, or, in other words, it becomes a form of recognition memory. I will review recent experimental data which seems to support this theory over the more general spatial or memory theories traditionally applied to hippocampus.

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Section: Slipping Out Of Contextmentioning

confidence: 83%

“…By pooling across the groups, a population could be generated with 18 lesioned animals. These animals showed small but significant deficits even in the 15 s condition [253].…”

Section: Slipping Out Of Contextmentioning

confidence: 87%

Section: Hmmentioning

confidence: 99%

Section: Slipping Out Of Contextmentioning

confidence: 99%

See 2 more Smart Citations

The hippocampal debate: are we asking the right questions?

Redish

2001

Behavioural Brain Research

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“…Increasing evidence suggests that the neuronal interaction between hippocampus and neocortex also plays an important role in memory formation (Jutras et al, 2009;Sirota et al, 2003) and memory functions degrade after damage to the hippocampus (Manns et al, 2003;Zola et al, 2000). Interestingly, we found that the left and right temporal lobes turn out to be the driving forces for the highfrequency overconnectivity in older age, which is directly related to cognitive decline.…”

mentioning

confidence: 57%

Development of large-scale functional networks over the lifespan

Schlee¹,

Leirer²,

Kolassa³

et al. 2012

Neurobiology of Aging

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Abstract:We investigated the development of large-scale functional networks over the lifespan by examining resting MEG of 53 healthy participants aged 18-89. Results show differential developments across the lifespan for low and high frequency networks. Delta frequency (2-4 Hz) networks decrease in size, while beta/gamma frequency (16 Hz) networks increase in size with age. The right frontal lobe and bilateral temporal areas were found to be important relay stations in high frequency networks. Normal age-related declines in visual memory and visuoconstructive capabilities were associated with the age-related increase of functional connectivity in both temporal lobes.

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Memory Systems

Eichenbaum¹

2003

Handbook of Psychology

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The idea that there are multiple memory systems in the brain has a long and interesting history. Early views, based on philosophical considerations and introspection suggested distinctions between recollective memory, habit formation, and the adoption of preferences and aversions to arbitrary stimuli. Early experimental work focused on controversies over which of these is the fundamental mechanism that underlies memory. A reconciliation of these divergent views has emerged from recent studies in the cognitive neuroscience of memory showing that these different forms of memory can be selectively disrupted by damage to distinct brain regions. This research, and parallel characterizations of neural activity in different brain areas, has shown that the three major forms of long‐term memory are supported by distinct brain systems. These include: (1) a cortical‐hippocampal circuit that mediates declarative memory, our capacity to recollect facts and events, (2) motor memory subsystems involving on a cortical‐neostriatal circuit that mediates habit formation and a brainstem‐cerebellar circuit that mediates sensori‐motor adaptations, and (3) a circuit involving subcortical and cortical pathways through the amygdala that mediates the attachment of affective status and emotional responses to previously neutral stimuli.

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Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region

Cited by 422 publications

References 50 publications

The hippocampal debate: are we asking the right questions?

The hippocampal debate: are we asking the right questions?

Development of large-scale functional networks over the lifespan

Memory Systems

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