Impaired retinal microcirculation in patients with non-obstructive coronary artery disease

Ren, Yun; Hu, Yijun; Liu, Cong; Zhong, Pingting; Liu, Hui; Wang, Huimin; Kuang, Yu; Fu, Bingqi; Wang, Yan; Zhao, Hanpeng; Zeng, Xiaomin; Kong, Huiqian; Lawali, Dan Jouma Amadou Maman; Yu, Danqing; Yu, Honghua; Yang, Xiaohong

doi:10.1016/j.mvr.2023.104533

Cited by 10 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A different study in 2023 found that patients with obstructive coronary artery disease (OCAD) (>50% stenosis in at least one major coronary artery) and non-obstructive coronary artery disease (NOCAD) (20-50% stenosis in all major coronary arteries) had significantly reduced VD in all regions of the superficial vessel plexus and in all regions except for the fovea in the deep vessel plexus compared to the control. Additionally, a more significant decrease in VD was found in OCAD patients versus that in NOCAD patients [39].…”

Section: Atherosclerotic Diseasementioning

confidence: 79%

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

Kellner,

Harris,

Ciulla

et al. 2024

JCM

View full text Add to dashboard Cite

Alterations in microvasculature represent some of the earliest pathological processes across a wide variety of human diseases. In many organs, however, inaccessibility and difficulty in directly imaging tissues prevent the assessment of microvascular changes, thereby significantly limiting their translation into improved patient care. The eye provides a unique solution by allowing for the non-invasive and direct visualization and quantification of many aspects of the human microvasculature, including biomarkers for structure, function, hemodynamics, and metabolism. Optical coherence tomography angiography (OCTA) studies have specifically identified reduced capillary densities at the level of the retina in several eye diseases including glaucoma. This narrative review examines the published data related to OCTA-assessed microvasculature biomarkers and major systemic cardiovascular disease. While loss of capillaries is being established in various ocular disease, pilot data suggest that changes in the retinal microvasculature, especially within the macula, may also reflect small vessel damage occurring in other organs resulting from cardiovascular disease. Current evidence suggests retinal microvascular biomarkers as potential indicators of major systemic cardiovascular diseases, including systemic arterial hypertension, atherosclerotic disease, and congestive heart failure.

show abstract

Section: Atherosclerotic Diseasementioning

confidence: 79%

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

Kellner,

Harris,

Ciulla

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…A single study reported a non-significant difference in FAZ area between CAD and no-CAD patients, but it included a limited number of cases (67 CAD patients, 37 healthy controls) compared to other research (Figure 6). [11,17,20].…”

Section: Resultsmentioning

confidence: 99%

Retinal Structural and Vascular Changes in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis

Rusu,

Horvath,

Tinica

et al. 2024

Life

View full text Add to dashboard Cite

Background: Retinal microvascular anomalies have been identified in patients with cardiovascular conditions such as arterial hypertension, diabetes mellitus, and carotid artery disease. We conducted a systematic review and meta-analysis (PROSPERO registration number CRD42024506589) to explore the potential of retinal vasculature as a biomarker for diagnosis and monitoring of patients with coronary artery disease (CAD) through optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods: We systematically examined original articles in the Pubmed, Embase, and Web of Science databases from their inception up to November 2023, comparing retinal microvascular features between patients with CAD and control groups. Studies were included if they reported sample mean with standard deviation or median with range and/or interquartile range (which were computed into mean and standard deviation). Review Manager 5.4 (The Cochrane Collaboration, 2020) software was used to calculate the pooled effect size with weighted mean difference and 95% confidence intervals (CI) by random-effects inverse variance method. Results: Eleven studies meeting the inclusion criteria were incorporated into the meta-analysis. The findings indicated a significant decrease in the retinal nerve fiber layer (WMD −3.11 [−6.06, −0.16]), subfoveal choroid (WMD −58.79 [−64.65, −52.93]), and overall retinal thickness (WMD −4.61 [−7.05, −2.17]) among patients with CAD compared to controls (p < 0.05). Furthermore, vascular macular density was notably lower in CAD patients, particularly in the superficial capillary plexus (foveal vessel density WMD −2.19 [−3.02, −1.135], p < 0.0001). Additionally, the foveal avascular zone area was statistically larger in CAD patients compared to the control group (WMD 52.73 [8.79, 96.67], p = 0.02). Heterogeneity was significant (I2 > 50%) for most features except for subfoveal choroid thickness, retina thickness, and superficial foveal vessel density. Conclusion: The current meta-analysis suggests that retinal vascularization could function as a noninvasive biomarker, providing additional insights beyond standard routine examinations for assessing dysfunction in coronary arteries.

show abstract

Optical coherence tomography angiography in cardiovascular disease

Runsewe,

Srivastava,

Sharma

et al. 2024

Progress in Cardiovascular Diseases

View full text Add to dashboard Cite

Impaired retinal microcirculation in patients with non-obstructive coronary artery disease

Cited by 10 publications

References 38 publications

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease

Retinal Structural and Vascular Changes in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis

Optical coherence tomography angiography in cardiovascular disease

Contact Info

Product

Resources

About