2023
DOI: 10.1111/gbb.12870
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Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro‐behavioral mechanisms of reversal learning

Tobias Bast,
Rachel Grasmeder Allen,
Silvia Maggi
et al.

Abstract: In this issue, Griesius et al report that heterozygous Dlg2+/‐ rats showed a reversal learning impairment on a specific bowl‐digging task, whereas other reversal tasks were unaffected. The study suggests that Dlg2 gene disruption, which has been linked to neuropsychiatric disorders, including schizophrenia, may cause relatively specific impairments in reversal learning, an important aspect of cognitive flexibility. The study draws attention to two important issues regarding the neuro‐behavioral mechanisms of r… Show more

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