Impaired secretion of parathyroid hormone is coherent to diabetic hemodialyzed patients

Inaba, Masaaki; Okuno, Senji; Nagasue, Kyoko; Otoshi, Tatsuyuki; Kurioka, Yasuko; Maekawa, Kiyoshi; Kumeda, Yasuro; Imanishi, Yasuo; Ishimura, Eiji; Ohta, Tomohiro; Morii, Hirotoshi; Kim, Masao; Nishizawà, Yoshiki

doi:10.1053/ajkd.2001.27423

Cited by 32 publications

(14 citation statements)

References 13 publications

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“…CKD-MBD has two distinct components; high PTH related to high bone turn over and low PTH resulting in adynamic bone disease. 14 Diabetic patients 17 and those with poor glycaemic control 9,12,13 are reported to have low iPTH and at high risk of vascular calcification 18 , accelerated peripheral vascular disease 19 and adverse cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Serum Intact Parathyroid Hormone Level is Inversely Correlated with Glycated Haemoglobin in Diabetic Chronic Kidney Disease Stages 3-5 Predialysis Patients

et al. 2017

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Introduction: Diabetes mellitus (DM) is one of the leading causes of chronic kidney disease (CKD). Management of chronic kidney disease-mineral and bone disorder (CKD-MBD 77±2.14, 6.8±3.0, 141.1±75.7, 8.1±1.2, 5.2±1.9,164.1±135.3 and 229.7±151.2 respectively. Mean HbAlc (%) and iPTH (pg/ml) in CKD stages 3, 4 and 5 were 8.36±1.59 and 171.7±127.9, 7.99±1.92 and 179.5±131.4, and 7.77±2.14 and 273.8±119.2

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Section: Discussionmentioning

confidence: 99%

Serum Intact Parathyroid Hormone Level is Inversely Correlated with Glycated Haemoglobin in Diabetic Chronic Kidney Disease Stages 3-5 Predialysis Patients

et al. 2017

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“…These therapeutic effects were shown even in patients with DM, who are characterized by low bone turnover resulting from impaired secretion of PTH (5,6).…”

Section: Discussionmentioning

confidence: 99%

“…ABD is reported to be detected in onefourth of bone biopsy specimens in dialysis patients (2,3). Akizawa et al revealed that Japanese dialysis patients with serum levels of intact parathyroid hormone (iPTH) below 60 pg/mL had a high incidence of ABD in bone biopsy specimens (4 (5,6).…”

Section: Introductionmentioning

confidence: 99%

Effect of Sevelamer Hydrochloride on Markers of Bone Turnover in Japanese Dialysis Patients with Low Biointact PTH Levels

et al. 2007

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“…High Turnover Bone Disease (HTBD) due to high iPTH level and Low Turnover Bone Disease (LTBD) due to comparatively low iPTHlevel [7]. It has been revealed in some studies that, usually diabetic ESRD patients on MHD have lower iPTH level than non-diabetic ESRD patients on MHD [8][9][10].Increasing evidence suggests that,in both diabetic and non-diabetic haemodialyzed patients, impaired iPTH secretion appears to be the main determinant responsible for decreased bone turnover and 'adynamic bone disease [11].…”

mentioning

confidence: 99%

Functional Hypoparathyroidism Among Type 2 Diabetic Patients on Hemodialysis: Impact of Glycemic Control.

Hassaan.¹,

Rashad²,

Hammam.³

et al. 2017

IJAR

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Background:End-stage renal disease has become a public health concern worldwide. Type 2 diabetes is associated with significantly accelerated rates of diabetic nephropathy. There are controversies about the role of intact parathyroid hormone (iPTH) in the pathogenesis of osteodystrophy among diabetic patients on regular hemodialysis. We aimed to estimate serum levels of iPTH, 25-hydroxyvitamin D and to clarify the possible relationships between iPTH and HbA1c ;which reflect the glycemic control as well as other clinical and biochemical parameters in end-stage renal disease patients on regular hemodialysis. Subjects and methods: A case-control study of 84end-stage renal disease patients on maintenance hemodialysis thrice weekly.Patients were stratified into three groups;group1:28 diabetic patients with good glycemic control(HbA1c < 7), group 2:28 diabetic patients with poor glycemic control(HbA1c >7), and group3:28non diabetic patients, In all studied participants,blood urea, serum creatinine , calcium, phosphorus, albumin, alkaline phosphatase, lipid profile, HbA1c, fasting blood glucose (FBG),post prandial blood glucose (PPBG) and25-hydroxyvitamin Dwere measured.Also, we estimate serum iPTHlevels by ADVIA CENTAUR instrument using Chemiluminescence principle. Results:Non diabetic patienton chronic hemodialysis had significantly higher values of serum 25-hydroxyvitamin D,serum iPTHmore than diabetic group, moreover diabetic patients with poor glycemic control had significantly lower values of serum 25-hydroxyvitamin D and serum iPTH, compared to good glycemic control.In diabetic patients with poor glycemic control,iPTHlevel was negatively correlated with Alkaline phosphatase,post prandial blood glucose, fasting blood glucose, as well as HbA1c. In patients with good glycemic control serum iPTHlevel was positively correlated with25-hydroxyvitamin D., there were significant negative correlations betweeniPTH level and creatinine, alkaline phosphatase, phosphorous, albumin, post prandial blood glucose, fasting blood glucose, as well as HbA1c.Stepwise linear regression analysis showed that, serum iPTH levels were independently correlated with 25-hydroxyvitamin D with diastolic blood pressure,

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Impaired secretion of parathyroid hormone is coherent to diabetic hemodialyzed patients

Cited by 32 publications

References 13 publications

Serum Intact Parathyroid Hormone Level is Inversely Correlated with Glycated Haemoglobin in Diabetic Chronic Kidney Disease Stages 3-5 Predialysis Patients

Serum Intact Parathyroid Hormone Level is Inversely Correlated with Glycated Haemoglobin in Diabetic Chronic Kidney Disease Stages 3-5 Predialysis Patients

Effect of Sevelamer Hydrochloride on Markers of Bone Turnover in Japanese Dialysis Patients with Low Biointact PTH Levels

Functional Hypoparathyroidism Among Type 2 Diabetic Patients on Hemodialysis: Impact of Glycemic Control.

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