Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

Gilleen, James; Shergill, Sukhwinder S.; Kapur, Shitij

doi:10.1017/s0033291714001718

Cited by 28 publications

(21 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Impaired subjective well-being is also associated with reduced anterior cingulate activity during reward processing, which may lead to a reduction in the integration of environmental stimuli and reward outcomes [70]. Future research should scrutinize the impact of the intervention on biological variables.…”

Section: Discussionmentioning

confidence: 99%

Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial

Favrod

Nguyen

Chaix

et al. 2019

Psychother Psychosom

View full text Add to dashboard Cite

Background: Negative symptoms are frequent in patients with schizophrenia and are associated with marked impairments in social functioning. The efficacy of drug-based treatments and psychological interventions on primary negative symptoms remains limited. The Positive Emotions Programme for Schizophrenia (PEPS) is designed to improve pleasure and motivation in schizophrenia patients by targeting emotion regulation and cognitive skills relevant to apathy and anhedonia. The main hypothesis of this study is that patients who attend 8 one-hour sessions of PEPS and treatment as usual (TAU) will have lower total apathy-avolition and anhedonia-asociality composite scores on the Scale for the Assessment of Negative Symptoms (SANS) than patients who attend only TAU. Methods: Eighty participants diagnosed with schizophrenia or schizoaffective disorder were randomized to receive either TAU or PEPS + TAU. The participants were assessed by independent evaluators before randomization (T0), in a post-test after 8 weeks of treatment (T1) and at a 6-month follow-up (T2). Results: The post-test results and 6-month follow-up assessments according to an intention-to-treat analysis showed that the apathy and anhedonia composite scores on the SANS indicated statistically greater clinical improvements in PEPS participants than in non-PEPS participants. In the post-test, anhedonia but not apathy was significantly improved, thus favouring the PEPS condition. These results were sustained at the 6-month follow-up. Conclusions: PEPS is an effective intervention to reduce anhedonia in schizophrenia. PEPS is a short, easy-to-use, group-based, freely available intervention that is easy to implement in a variety of environments (ClinicalTrials.gov ID: NCT02593058).

show abstract

Section: Discussionmentioning

confidence: 99%

Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial

Favrod

Nguyen

Chaix

et al. 2019

Psychother Psychosom

View full text Add to dashboard Cite

show abstract

“…Neuroimaging studies examining striatal responses to the receipt of monetary rewards in schizophrenia have also shown a consistent pattern of intact responses, with robust ventral striatal responses to the receipt of money in unmedicated patients (Nielsen et al 2012a, b) and patients treated with either typical or atypical antipsychotics (Kirsch et al 2007;Simon et al 2009;Walter et al 2009;Dowd and Barch 2012;Morris et al 2012;Gilleen et al 2014;Wolf et al 2014;Mucci et al 2015). Further, studies have also shown intact feedback negativity responses, an ERP component in response to explicit feedback, to the receipts of rewards and losses in schizophrenia (Horan et al 2011;Morris et al 2011).…”

Section: Monetary Rewardsmentioning

confidence: 95%

“…Further, there is recent work suggesting that working memory impairments may make a significant contribution to reinforcement learning deficits in schizophrenia (Collins et al 2014). Further, there is a growing literature suggesting altered activity in cortical regions involved in cognitive control during anticipation/prediction error (Walter et al 2009;Gilleen et al 2014) and during reinforcement learning (Waltz et al 2013;Culbreth et al in submission). Such findings are consistent with the larger literature suggesting altered cognitive control function in schizophrenia and are also consistent with the growing basic science literature suggesting important interactions between what have been referred to as "model-free" learning systems (e.g., DA in the striatum) and "model-based" learning systems that engage prefrontal and parietal systems that support representations of action--outcome models (Glascher et al 2010;Daw et al 2011;Doll et al 2012;Lee et al 2014;Otto et al 2015).…”

Section: Reinforcement Learningmentioning

confidence: 99%

Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia

Deanna¹,

Pagliaccio²,

Luking³

2015

Current Topics in Behavioral Neurosciences

191

151

View full text Add to dashboard Cite

Motivational and hedonic impairments are core aspects of a variety of types of psychopathology. These impairments cut across diagnostic categories and may be critical to understanding major aspects of the functional impairments accompanying psychopathology. Given the centrality of motivational and hedonic systems to psychopathology, the Research Domain Criteria (RDoC) initiative includes a "positive valence" systems domain that outlines a number of constructs that may be key to understanding the nature and mechanisms of motivational and hedonic impairments in psychopathology. These component constructs include initial responsiveness to reward, reward anticipation or expectancy, incentive or reinforcement learning, effort valuation, and action selection. Here, we review behavioral and neuroimaging studies providing evidence for impairments in these constructs in individuals with psychosis versus in individuals with depressive pathology. There are important differences in the nature of reward-related and hedonic deficits associated with psychosis versus depression that have major implications for our understanding of etiology and treatment development. In particular, the literature strongly suggests the presence of impairments in in-the-moment hedonics or "liking" in individuals with depressive pathology, particularly among those who experience anhedonia. Such deficits may propagate forward and contribute to impairments in other constructs that are dependent on hedonic responses, such as anticipation, learning, effort, and action selection. Such hedonic impairments could reflect alterations in dopamine and/or opioid signaling in the striatum related to depression or specifically to anhedonia in depressed populations. In contrast, the literature points to relatively intact in-the-moment hedonic processing in psychosis, but provides much evidence for impairments in other components involved in translating reward to action selection. Particularly, individuals with schizophrenia exhibit altered reward prediction and associated striatal and prefrontal activation, impaired reward learning, and impaired reward-modulated action selection.

show abstract

“…For instance, Penn et al [30] have postulated a role for WBT in improving functional outcomes as an additional ingredient to CBT in psychotic disorders. Indeed, subjective well-being appears to be impaired in schizophrenia and is associated with reduced anterior cingulated activity during reward processing, which may induce reduced integration of environmental stimuli, motivated behavior and reward outcome [31]. …”

Section: Current Indicationsmentioning

confidence: 99%

Well-Being Therapy: Current Indications and Emerging Perspectives

Fava

2016

Psychother Psychosom

View full text Add to dashboard Cite

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

Cited by 28 publications

References 49 publications

Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial

Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial

Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia

Well-Being Therapy: Current Indications and Emerging Perspectives

Contact Info

Product

Resources

About