Impaired thiol/disulphide homoeostasis in children with steroid‐sensitive nephrotic syndrome

Abstract

Background Abnormal thiol/disulphide homoeostasis (TDH) is responsible for the pathogenesis of various diseases. We aimed to examine the TDH in children with steroid‐sensitive nephrotic syndrome (SSNS). Methods A total of 131 children, 60 with SSNS and 71 healthy controls, participated in the study. Plasma total thiol (TT), native thiol (SH) and disulphide (SS) levels in the SSNS during remission and control groups were estimated using a new method developed by Erel and Neselioglu. Results Albumin, TT, SH levels and SH/TT ratio were decreased, whereas SS/SH and SS/TT ratios were elevated in SSNS group compared with control group. However, there was no significant difference in SS levels between the two groups. Albumin level was positively correlated with TT, SH and SS levels in the SSNS group. Conclusions We found that TDH shifts in favour of oxidants in children with SSNS in remission. This shift indicates that SSNS patients are exposed to augmented oxidative stress.

Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection

“…ROS triggers a transcription factor NF-κB-driven proinflammatory cytokines (e.g., TNF-α and IL-6) as well as chemokines (e.g., macrophage inflammatory protein-1), and thus causing an uncontrolled cytokine storm that promotes acute lung injury/ARDS in COVID-19-infected patients [ 22 ]. Thiols are part of the antioxidant defense systems that prevent or mitigate the damage of cellular components (e.g., proteins, lipids, and nucleic acids) by ROS in the organism [ 23 ]. Recently, Erel et al [ 13 ] investigated the thiol levels in COVID-19-infected patients and found that thiol levels were lower in COVID-19 patients compared to healthy individuals.…”

Changes in Serum Thiol-Disulphide Homeostasis in Sheep with Gastrointestinal Nematodes

“…The thiols have a high vulnerability to oxidation [45], forming SS when oxidised [48,49]. Since albumin is the main component of the plasma thiol pool, the SS/TT, SS/SH and SH/TT ratios are used to avoid the possible effect of albumin [25].…”

“…The study of thiol-disulphide homeostasis, which involves the analysis of serum total thiol (TT), native thiol (SH), and disulphide (SS) concentrations, is gaining interest in human medicine to evaluate oxidative status in different diseases [22][23][24][25]. Previous studies suggested that thiol-disulphide homeostasis can be used as a marker of oxidative stress in sheep during sarcoptic mange infection [26]; however, to the author's knowledge, no information about the evaluation of these biomarkers in gastrointestinal parasitism in sheep has been reported.…”