Impaired Treg and <scp>NK</scp> cells profile in overweight women with gestational diabetes mellitus

Lobo, Thalita Frutuoso; Borges, Cannila de Moraes; Mattar, Rosiane; Gomes, Caio Perez; Angelo, Ana G.S.; Pendeloski, Karen Priscilla Tezotto; Daher, Sílvia

doi:10.1111/aji.12810

Cited by 41 publications

(46 citation statements)

References 27 publications

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“…Sheu et al reported that there was no difference in Treg population between GDM and controls, but they did not describe which markers were used to define the cell subset. Accordingly, two other studies including more specific markers showed no differences in the percentage of total TCD4 + and TCD4 + CD25 + FOXP3 + CD127 − between controls and GDM …”

Section: Immune Cellsmentioning

confidence: 87%

“…Two groups of investigators analysed TCD4 + and TCD8 + cells in PB of healthy and GDM patients at third trimester of pregnancy. Both studies showed an increased proportion of activated TCD4 cells and a decreased percentage of activated TCD8 in diabetic patients, and these changes were more marked in the insulin‐treated subgroup.…”

Section: Immune Cellsmentioning

confidence: 92%

“…[26][27][28][29][30] Friebe-Hoffman et al 28 found a lower frequency of TCD4 + in GDM patients compared to controls, while the others did not. [26][27][28]30 Two groups of investigators 26,27 analysed TCD4 + and TCD8 + cells in PB of healthy and GDM patients at third trimester of pregnancy. Both studies showed an increased proportion of activated TCD4 cells and a decreased percentage of activated TCD8 in diabetic patients, and these changes were more marked in the insulin-treated subgroup.…”

Section: T Lymphocytesmentioning

confidence: 96%

“…T lymphocyte and its subpopulations are the most investigated cells in GDM due to its recognized role in maternal immune response. Five studies reported the percentage of total circulating TCD3 + TCD4 + , and two of them analysed the frequency of total TCD8 + as well . Friebe‐Hoffman et al found a lower frequency of TCD4 + in GDM patients compared to controls, while the others did not …”

Section: Immune Cellsmentioning

confidence: 99%

“…Mahmoud et al also observed increased frequency of TCD4 + CD45RO and TCD4 + CD29 + cells—which seems to represent activated subsets—and TCD8 + CD45 lymphocytes, but lower percentages of TCD4 + CD45RA, which may act as a suppressor. In turn, Pendeloski et al observed impaired expression of co‐stimulatory molecules in TCD4 and TCD8, suggesting a state of super‐activation and a deficiency of suppressive mechanisms. Using different phenotype markers, altogether these findings are in agreement with the hypothesis that a pro‐inflammatory profile is observed in GDM.…”

Section: Immune Cellsmentioning

confidence: 99%

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Unveiling the pathophysiology of gestational diabetes: Studies on local and peripheral immune cells

et al. 2020

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Gestational diabetes mellitus (GDM) has been associated with impaired maternal immune response. Our aim was to review the available literature linking immune cells profile to GDM, in order to comprehend the role that different subpopulations play in the development of this pathology. We searched in PubMed for studies published in the last decade on circulating levels and placenta expression of immune cells on GDM. We identified 18 studies with several differences regarding the study design, clinical characteristics, number of participants, cell subpopulation and type of sample. Most studies assessed only one subpopulation either in peripheral blood or placenta and did not analyse functional properties of the cells. The most frequently evaluated immune cells were T lymphocytes, especially regulatory T (Tregs), and natural killer (NK) cells in the peripheral blood, and placental macrophages. No studies analysing B cells were identified, and only one study each evaluating γδT cells, dendritic cell (DC) and monocytes was found. Although there are controversies, at least one study reported positive association between GDM and CD4+(activated), Tregs, Th17 and γδT cells; neutrophil/lymphocyte; NK cell (cytotoxic); macrophages; and monocytes. The number of studies is still small, so caution should be exercised in interpreting the data, and further research is required to validate these findings and establish the role of adaptive and innate immune cells in GDM pathophysiology.

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Section: Immune Cellsmentioning

confidence: 87%

Section: Immune Cellsmentioning

confidence: 92%

Section: T Lymphocytesmentioning

confidence: 96%

Section: Immune Cellsmentioning

confidence: 99%

Section: Immune Cellsmentioning

confidence: 99%

See 3 more Smart Citations

Unveiling the pathophysiology of gestational diabetes: Studies on local and peripheral immune cells

et al. 2020

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Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

Zou

Zhou

Huang

et al. 2021

Journal of Leukocyte Biology

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Periodontitis is a common chronic inflammatory disease that can result in tooth loss and poses a risk to systemic health. Lymphocytes play important roles in periodontitis through multiple mechanisms. Regulatory lymphocytes including regulatory B cells (Bregs) and T cells (Tregs) are the main immunosuppressive cells that maintain immune homeostasis, and are critical to our understanding of the pathogenesis of periodontitis and the development of effective treatments. In this review, we discuss the phenotypes, roles, and modulating strategies of regulatory lymphocytes including Bregs and Tregs in periodontitis and frequently cooccurring inflammatory diseases such as rheumatoid arthritis, Alzheimer disease, diabetes mellitus, and stroke. The current evidence suggests that restoring immune balance through therapeutic targeting of regulatory lymphocytes is a promising strategy for the treatment of periodontitis and other systemic inflammatory diseases.

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Cytokines and pregnancy: Potential regulation by histone deacetylases

Munro

Balakrishnan

Lissaman

et al. 2021

Molecular Reproduction Devel

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Cytokines are important regulators of pregnancy and parturition. Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre‐eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.

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Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus

Abstract: The association between obesity and GDM is a condition where it is observed impaired Treg and NK cells profile, findings that seem to be related with the development of IR and inflammation.

Cited by 41 publications

References 27 publications

Unveiling the pathophysiology of gestational diabetes: Studies on local and peripheral immune cells

Unveiling the pathophysiology of gestational diabetes: Studies on local and peripheral immune cells

Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases

Cytokines and pregnancy: Potential regulation by histone deacetylases

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