2013
DOI: 10.1128/jvi.02701-12
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Impaired Virion Secretion by Hepatitis B Virus Immune Escape Mutants and Its Rescue by Wild-Type Envelope Proteins or a Second-Site Mutation

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Cited by 54 publications
(64 citation statements)
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“…2), but it led to a decrease in HBV virion production, as previously reported (35). This defect was not due to the reduced synthesis or stability of the nonglycosylated L-HBsAg mutant compared to that of the wt.…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…2), but it led to a decrease in HBV virion production, as previously reported (35). This defect was not due to the reduced synthesis or stability of the nonglycosylated L-HBsAg mutant compared to that of the wt.…”
Section: Discussionsupporting
confidence: 60%
“…Only in a few cases of chronic infection is this pattern modified to include an additional site (35), a strategy used more extensively by other enveloped viruses, such as HIV or hepatitis C virus, to escape neutralizing antibodies (13). In this study, the functions underlying the peculiar glycosylation pattern of HBV envelope proteins were explored, in particular with respect to position 146 in the AGL at which N-glycosylation occurs and the systematic coexistence of glycosylated and nonglycosylated N146.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, we detected 10 mutation sites at the 'a' determinant. Previous studies suggested that genetic changes in the antigenic epitopes might alter the conformation of immunogenic determinants, which reduce binding affinity to relevant immune molecules and induce the mutant escape from immune surveillance (25,26). Therefore, the mutations in these epitopes may have contributed to the persistence of HBV infection.…”
Section: Discussionmentioning
confidence: 99%
“…A total of 1368 full-length RT sequences were obtained from the cross-sectional study subjects (IT: 479, IA: 461, and IC: 428, respectively). The number of sequences per sample in IT, IA and IC phases were 23 (22)(23)(24)(25)(26), 23 (21)(22)(23)(24)(25)(26)(27) and 20 (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), respectively (P = 0.10). Another 1147 sequences (49% from the cross-sectional study) were obtained for the longitudinal analysis.…”
Section: Clinical Characteristicsmentioning
confidence: 98%
“…Cloning of the RT domain alone will only give essential information about changes within the S domain, e.g. stop mutations that can lead to secretion-deficient variants [9], or other mutations within the antigenic determinant, responsible for HBV immune escape [10,11,12,13] and their transmission [14]. …”
Section: Amplification and Cloning Of Hbv Genome Variantsmentioning
confidence: 99%