Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily affecting retroperitoneal adipose tissue

Calderón-DuPont, Diana; Romero-Córdoba, Sandra; Tello, Jessica K.; Espinosa, Aranza; Guerrero, Brenda; Contreras, Alejandra; Morán-Ramos, Sofía; Dı́az-Villaseñor, Andrea

doi:10.1016/j.taap.2023.116428

Cited by 4 publications

(2 citation statements)

References 86 publications

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“…This whole phenomenon will reduce the body weight, muscle mass and activity of animals. [12][13][14] The mean weight of the reproductive tract was significantly less in experimental animals in comparison with the control (p-value<0.05). The possible cause of a decrease in the weight of the reproductive tract after exposure to arsenic may be due to decreases in plasma gonadotrophins and estradiol levels which are essential for the normal morphology and histology of the reproductive organs of the female.…”

Section: Discussionmentioning

confidence: 91%

Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats

Mir,

Yasmeen

et al. 2024

JRMC

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Objective: To find out the toxic effects of arsenic on the histology of the vagina and reproductive hormones of female Sprague Dawley rats. Methods: 60 female Sprague Dawley rats were divided into control group A and experimental group B with 30 rats in each group. The gross weight of all the rats was checked before and at the end of the experiment. After one week of acclimatization, the control group was administered 10ml of distilled water by oral gavage daily for 14 days and the experimental group was administered 4µg of sodium arsenite dissolved in 10ml of distilled water by oral gavage daily for 14 days. After being euthanized by chloroform inhalation on day 15, blood from each rat was drawn by a single intra-cardiac puncture and stored for biochemical analysis. After that, rats were sacrificed and the whole reproductive tract was removed and vaginal sections were prepared and stained with hematoxylin and eosin (H&E ). The histological parameters were analyzed by using Image J software. Whereas, biochemical parameters e.g. serum LH and FSH levels were analyzed by ELISA. Results: After exposure to a low dose of arsenic administered for a short period, the gross weight of rats, weight of reproductive tract, height of vaginal epithelium and serum FSH and LH values were significantly reduced in experimental animals as compared to control animals with p-value < 0.05. Conclusion: Low dose of arsenic given via contaminated drinking water for a short period is very toxic to the female reproductive tract which is evident by the histological changes in the vagina and deranged hormonal profile of female Sprague Dawley rats. Keywords: Arsenic, FSH, Free radicals, LH, Oxidative stress, Vagina.

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Section: Discussionmentioning

confidence: 91%

Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats

Mir,

Yasmeen

et al. 2024

JRMC

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“…As exposure was shown to induce retroperitoneal adipose tissue hypertrophy with impairment of insulin-induced lipolysis characterized by down-regulation of genes involved in lipolysis, fatty acid uptake, oxidation, and glycerol transport [ 123 ]. In agreement with the results of epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Martins

Ferrer

Tinkov

et al. 2023

Toxics

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Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Moreover, the etiology of MetS is multifactorial, involving many environmental factors, including toxicant exposures. Several studies have associated MetS with heavy metals exposure, which is the focus of this review. Environmental and/or occupational exposure to heavy metals are a major risk, contributing to the development of chronic diseases. Of particular note, toxic metals such as mercury, lead, and cadmium may contribute to the development of MetS by altering oxidative stress, IL-6 signaling, apoptosis, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, and other mechanisms. In this review, we discuss the known and potential roles of heavy metals in MetS etiology as well as potential targeted pathways that are associated with MetS. Furthermore, we describe how new approaches involving proteomic and transcriptome analysis, as well as bioinformatic tools, may help bring about an understanding of the involvement of heavy metals and metalloids in MetS.

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Arsenic induces metabolome remodeling in mature human adipocytes

Gasser,

Lenglet,

Bararpour

et al. 2023

Toxicology

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Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily affecting retroperitoneal adipose tissue

Cited by 4 publications

References 86 publications

Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats

Ameliorating Effects of Arsenic-Induced Toxicity On The Histology Of Vagina And Reproductive Hormones Of Female Sprague Dawley Rats

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Arsenic induces metabolome remodeling in mature human adipocytes

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