Impairment in clock-time estimation following right hemisphere ischemic damage

Morin, Catherine; Guigot, J.; Manaï, R; Vu, Phong Nguyen; Guérin, N.; Samson, Yves; Pradat-Diehl,; Touitou, Yvan

doi:10.1016/j.cogbrainres.2004.09.001

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…The duration‐responsive neural network presently identified also included the right orbitofrontal as well as the right anterior cingulate cortex (ACC) that is coactivated with the AIC in most but not all neuroimaging studies and that is supposed to be the initiation site for motor function [Craig, ]. The right hemispheric bias concerning the involvement of the frontal structures in our study is in concordance with the results of EEG [Monfort et al, ; Pouthas et al, ], fMRI [Lewis and Miall, ; Pouthas et al, ] and neuropsychological [Funnell et al, ; Harrington et al, ; Morin et al, ] studies suggesting a predominance of the right hemisphere in timing tasks. Reportedly, implicit and explicit temporal processing would take place in the left and right frontal regions, respectively [Coull and Nobre, ; Coull et al, ].…”

Section: Discussionsupporting

confidence: 91%

fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal

Pfeuty

Dilharreguy

Gerlier

et al. 2014

Human Brain Mapping

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The reason why human beings are inclined to overestimate the duration of highly arousing negative events remains enigmatic. The issue about what neurocognitive mechanisms and neural structures support the connection between time perception and emotion was addressed here by an event-related neuroimaging study involving a localizer task, followed by the main experiment. The localizer task, in which participants had to categorize either the duration or the average color of visual stimuli aimed at identifying the neural structures constitutive of a duration-specific network. The aim of the main experiment, in which participants had to categorize the presentation time of either neutral or emotionally negative visual stimuli, was to unmask which parts of the previously identified duration-specific network are sensitive to emotionally negative arousal. The duration-specific network that we uncovered from the localizer task comprised the cerebellum bilaterally as well as the orbitofrontal, the anterior cingulate, the anterior insular, and the inferior frontal cortices in the right hemisphere. Strikingly, the imaging data from the main experiment underscored that the right inferior frontal cortex (IFC) was the only region within the duration-specific network whose activity was increased in the face of emotionally negative pictures compared to neutral ones. Remarkably too, the extent of neural activation induced by emotionally negative pictures (compared to neutral ones) in this region correlated with a behavioral index reflecting the extent to which emotionally negative pictures were overestimated compared to neutral ones. The results are discussed in relation to recent models and studies suggesting that the right anterior insular cortex/IFC is of central importance in time perception.

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Section: Discussionsupporting

confidence: 91%

fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal

Pfeuty

Dilharreguy

Gerlier

et al. 2014

Human Brain Mapping

View full text Add to dashboard Cite

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“…A similar association was also found in studies investigating patients with extensive frontal lesions. 1,3 In contrast to this study, these other studies did not apply to patients with focal epileptogenic lesions in the frontal and temporal lobes.…”

Section: Discussioncontrasting

confidence: 58%

“…Further evidence for the right lateralization of cognitive estimation has been provided. 2,3 Tsujii et al 4 explained the involvement of the right hemisphere in cognitive estimation with the "dual-process theory of reasoning" 5 : human thinking is based on two different processes, namely heuristic and analytic processing of tasks. Heuristic processes are fast, automatic, and dependent on certain existing beliefs and knowledge whereas analytical conclusions are characterized as slow, sequential, and deductive.…”

Section: Introductionmentioning

confidence: 99%

Functional Dissociation between Cognitive Estimation and Object Naming in Focal Temporal and Frontal Lobe Epilepsies

Leuteritz

Schwarz

Walther

et al. 2018

International Journal of Epilepsy

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Purpose This study addresses specific impairments of cognitive estimation and object naming in patients with focal temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE). It was investigated whether selective impairments can be explained by differences in lesion localization and functional hemispheric specialization. Materials and Methods Seventy-eight patients (39 females, 39 males) with FLE and TLE were investigated using the German “Test zum Kognitiven Schätzen” and the “Boston Naming Test” to assess cognitive estimation abilities and visual object naming. Questions According to theoretical models that support a distinct hemispheric dominance for estimation and naming, it was expected that epilepsy localization in the right hemisphere would result in impairments of cognitive estimation, whereas patients with left epileptogenic foci would show deficits in object naming. Results In comparison to a healthy control group, a significant impairment in estimation performance was present in patients with right temporal mesial and right frontal epilepsy. A significant impairment of naming performance was found in patients with left temporal mesial, right temporal mesial, left temporal neocortical, and left frontal epilepsy. Overall, localization-dependent deficits were detected in patients with hippocampal sclerosis (cognitive estimation and object naming), right frontal epilepsy (cognitive estimation), and left temporal neocortical/left frontal epilepsy (object naming). In patients with right temporal neocortical epilepsy, no functional deficits were found. Conclusion It is hypothesized that there is a functional dissociation between cognitive estimation processes and object naming due to different functional specialization of the left and right hemispheres, respectively.

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“…To date, there has been relatively little investigation of perceptual timing within the stroke literature, and in particular with individuals following transient ischemic attack (TIA), where transient stroke symptoms resolve within 24 hours 33 34 . From the extant literature, findings have consistently demonstrated a gross underestimation of time interval in right-hemisphere damaged patients with neglect (RHD-N) 6 35 36 37 (see Supplementary Table for a summary of studies of perceptual timing after a stroke 6 35 36 37 38 39 40 41 ). While this underestimation has been frequently interpreted in the context of the pacemaker-accumulator model described above 7 15 16 , different suggestions have been proposed regarding the specific cause.…”

mentioning

confidence: 99%

Beyond Neglect: Preliminary Evidence of Retrospective Time Estimation Abnormalities in Non-Neglect Stroke and Transient Ischemic Attack Patients

Low

Perre

Ong

et al. 2016

Sci Rep

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Perception of the passage of time is essential for safe planning and navigation of everyday activities. Findings from the literature have demonstrated a gross underestimation of time interval in right-hemisphere damaged neglect patients, but not in non-neglect unilaterally-damaged patients, compared to controls. This study aimed to investigate retrospective estimation of the duration of a target detection task over two occasions, in 30 stroke patients (12 left-side stroke 15 right-side stroke, and 3 right-side stroke with neglect) and 10 transient ischemic attack patients, relative to 31 age-matched controls. Performances on visual short-term and working memory tasks were also examined to investigate the associations between timing abilities with residual cognitive functioning. Initial results revealed evidence of perceptual time underestimation, not just in neglect patients, but also in non-neglect unilaterally-damaged stroke patients and transient ischemic attack patients. Three months later, underestimation of time persisted only in left-side stroke and right-side stroke with neglect patients, who also demonstrated reduced short-term and working memory abilities. Findings from this study suggest a predictive role of residual cognitive impairments in determining the prognosis of perceptual timing abnormalities.

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Impairment in clock-time estimation following right hemisphere ischemic damage

Cited by 10 publications

References 6 publications

fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal

fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal

Functional Dissociation between Cognitive Estimation and Object Naming in Focal Temporal and Frontal Lobe Epilepsies

Beyond Neglect: Preliminary Evidence of Retrospective Time Estimation Abnormalities in Non-Neglect Stroke and Transient Ischemic Attack Patients

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