Impairment of attention network function in posterior circulation ischemia-evidence from the Attention Network Test

Li, Na; Li, Chuanjin; Xie, Xiaohui; Liu, Gang; Wang, Kai; Zhang, Wendong; Fan, Jin

doi:10.3389/fnhum.2022.1001500

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…Thus, objective and effective assessment using speci c rating scales is necessary. The ANT is an effective tool for assessing attention network e ciency of alerting, orienting, and executive functions and is widely used in other diseases, including Alzheimer's disease, posterior circulation ischemia and HIV-associated cognitive disorder [21][22][23] . This study highlights the bene t of the ANT in distinguishing cognitive impairment among patients with early forms of NS.…”

Section: Discussionmentioning

confidence: 99%

Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis

He,

Yuan,

Yuan

et al. 2024

Preprint

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Background: Attentional Network Test (ANT), was widely used to evaluate the performance of three attentional networks, i.e., alerting, orienting and executive attention networks. This study aimed to explore the characteristics of attention functions in HIV-negative patients with early forms of NS and their association with brain magnetic resonance imaging (MRI) abnormalities. Methods: 31 HIV-negative patients without NS, 30 HIV-negative patients with early forms of NS, and 35healthy controls enrolled from September 2020 to November 2022 were evaluated with the ANT and the Mini-Mental State Examination (MMSE). Brain MRI was performed in patients with and without NS. Results: There were no significant difference in the MMSE scores between the three groups. Patients with early forms of NS showed poorer performance in orienting and alerting functions than those without NS (F = 6.952, P = 0.011 and F = 8.794, P = 0.004, respectively); however, no difference was observed in executive function between the two groups (F = 0.001, P = 0.980). Multivariate analysis of variance using the Bonferroni post-hoc test indicated that patients with NS exhibited less efficient orienting function (P = 0.023), alerting function (P = 0.003) but not executive function (P = 0.99) than those without NS. Moreover, compared with contemporary healthy controls, a significant difference in orienting function was observed in patients with NS (P < 0.001). The NS group comprised more patients with MRI abnormalities in the frontal lobes and/or the temporoparietal junction than the non-NS group (24/25 vs. 13/19, P = 0.032). Conclusions: HIV-negative patients with early forms of NS demonstrated obvious orientation and alerting function impairment. Brain MRI abnormalities in the frontal and/or parietal lobes and/or the temporoparietal junction indicated the presence of potential neural structure and network priority barriers pertaining to selective attention deficit.

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Section: Discussionmentioning

confidence: 99%

Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis

He,

Yuan,

Yuan

et al. 2024

Preprint

View full text Add to dashboard Cite

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Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis

He,

Yuan,

Yuan

et al. 2024

Eur J Med Res

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Background The attentional network test (ANT) is widely used to evaluate the performance of three attentional networks: alerting, orienting and executive attention networks. This study aimed to investigate the characteristics of attention functions in HIV-negative patients with early forms of neurosyphilis (NS) and their correlation with abnormalities in brain magnetic resonance imaging (MRI). Methods Thirty patients with early forms of NS, 31 patients with syphilis but without NS (Non-NS) and 35 healthy controls were recruited from an HIV-negative cohort between September 2020 and November 2022. The participants were evaluated with the ANT and the Mini-Mental State Examination (MMSE). Brain MRI was performed in NS and Non-NS patients. Results No significant differences were observed in the MMSE scores among the three groups. However, patients with early forms of NS showed poorer performance in orienting and alerting functions than Non-NS group (F = 6.952, P = 0.011 and F = 8.794, P = 0.004, respectively); No significant difference was observed in executive function between the two groups (F = 0.001, P = 0.980). Multivariate analysis of variance using the Bonferroni post hoc test indicated that patients with NS exhibited less efficient orienting function ( P = 0.023), and alerting function ( P = 0.003) but not executive function ( P = 0.99), compared to Non-NS patients. Additionally, a significant difference was found in orienting function between patients with NS and healthy controls ( P < 0.001) compared to healthy controls. MRI scans revealed that the NS group had a higher prevalence of abnormalities in the frontal lobes and/or the temporoparietal junction compared to the Non-NS group (24/25 vs. 13/19, P = 0.032). Conclusions The orienting and alerting functions but not executive function were significantly less efficient in early forms of NS group than in the Non-NS group ( P < 0.01). This indicates deficits in selective attention in patients with early forms of NS. Brain MRI scans revealed abnormalities in the frontal and/or parietal lobes, as well as the temporoparietal junction, suggesting potential neuropathological correlates of these attentional deficits. Supplementary Information The online version contains supplementary material available at 10.1186/s40001-024-02004-1.

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Impairment of attention network function in posterior circulation ischemia-evidence from the Attention Network Test

Cited by 2 publications

References 53 publications

Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis

Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis

Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis

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