Impairment of autoregulation of optic nerve head blood flow during vitreous surgery in patients with hypertension and hyperlipidemia

Hashimoto, Ryuya; Sugiyama, Tetsuya; Ubuka, Makoto; Maeno, Takatoshi

doi:10.1007/s00417-017-3788-5

Cited by 9 publications

(11 citation statements)

References 45 publications

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“…Moreover, the MBR was reported to be lower in diabetes patients 16 and diabetic rabbits 17,18 . Likewise, the MBR in the vessel and tissue regions was significantly lower in hyperlipidemia patients 19 . Studies have shown that MBR-MT was stable regardless of age 10 and did not significantly affect in the eyes with the macula 20 .…”

Section: Discussionmentioning

confidence: 86%

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

Ismail

Chen

Faye

et al. 2020

Sci Rep

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Real-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75% stenosis was created by tying the common carotid artery with a plastic mandrel using a nylon suture. The plastic mandrel was gently removed, leaving a ligature. Neurological and behavioral assessments were recorded as the clinical indicator of stroke severity. With laser speckle flowgraphy, the pulse waveform parameters namely mean blur rate (MBR), blowout score (BOS), blowout time (BOT), rising rate, S1-area, falling rate (FR), S2-area, flow acceleration index (FAI), acceleration time index, resistive index (RI) and the difference between the maximum and minimum values of MBR (AC) were assessed in overall, vessel, and tissue regions of the optic nerve head (ONH). Longitudinally, BOS significantly increased until day 19 post-surgery, whereas FAI, RI, and AC significantly decreased. Beyond day 19, BOS, BOT, FR, FAI, RI, and AC significantly decreased. We defined two stages representing impaired vessel conditions, namely the vessel resistance phase, where BOS increases and FAI, RI, and AC decrease, and the vessel elasticity phase where BOS, BOT, FR, FAI, RI and AC decrease. These stages provide information about atherosclerosis, assessable non-invasively through the eye.

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Section: Discussionmentioning

confidence: 86%

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

Ismail

Chen

Faye

et al. 2020

Sci Rep

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“…The experimental protocol has been described in detail in previous studies [ 19 – 21 ]. We induced mydriasis by administering 1-2 drops of 0.5% tropicamide and 0.5% phenylephrine hydrochloride (Mydrin-P ophthalmic solution; Santen Pharmaceutical Co., Ltd., Osaka, Japan).…”

Section: Methodsmentioning

confidence: 99%

“…We used these measurements for the calculation of mean IOP values. SBP and DBP were measured in the same way as reported previously [ 19 – 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…The intraoperative IOP, blood pressure, pulse rate, and oxygen saturation (SpO2) were measured simultaneously with ONH blood flow using a method reported previously [ 19 – 21 ]. The mean blood pressure (MBP) was calculated from SBP/DBP according to the following formula [ 12 ]: MBP = 1/3 × (SBP − DBP) + DBP.…”

Section: Methodsmentioning

confidence: 99%

“…The present study aimed to investigate ONH blood flow autoregulation in four quadrants (superior, nasal, inferior, and temporal) in the supine position using laser speckle flowgraphy (LSFG) (LSFG-NAVI-OPE, Softcare Co., Ltd., Fukuoka, Japan) [ 18 – 21 ], during vitrectomy in order to determine whether there is a significant difference of autoregulatory capacity in response to OPP decrease in each ONH quadrant.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy

Hashimoto

Sugiyama

Maeno

2017

BioMed Research International

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Purpose The present study aimed to examine changes in optic nerve head (ONH) blood flow autoregulation in 4 quadrants (superior, nasal, inferior, and temporal) with decreased ocular perfusion pressure (OPP) during vitrectomy in order to determine whether there is a significant difference of autoregulatory capacity in response to OPP decrease at each ONH quadrant. Methods This study included 24 eyes with an epiretinal membrane or macular hole that underwent vitrectomy at Toho University Sakura Medical Center. Following vitrectomy, the tissue mean blur rate (MBR), which reflects ONH blood flow, was measured. Mean tissue MBRs in the four quadrants were generated automatically in the software analysis report. Measurements were conducted before and 5 and 10 min after intraocular pressure (IOP) elevation of approximately 15 mmHg in the subjects without systemic disorders. Results The baseline tissue MBR of the temporal quadrant was significantly lower than that of the other 3 quadrants (all P < 0.05). However, the time courses of tissue MBR in response to OPP decrease were not significantly different among the four quadrants during vitrectomy (P = 0.23). Conclusions There is no significant difference in the autoregulatory capacity of the four ONH quadrants in patients without systemic disorders during vitrectomy.

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Chinese herbal medicine for hypertension complicated with hyperlipidemia

Liu

Yang²,

Wang³

et al. 2021

Medicine

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Background: Hypertension combined with hyperlipidemia (HTN-HLP), as a common clinical chronic disease combination, will increase the incidence of cardiovascular and cerebrovascular diseases, increase the occurrence of sudden death and other adverse events. At present, the commonly used therapeutic drugs are mainly combined with antihypertensive drugs and lipid-lowering drugs, which not only have poor compliance, but also have adverse reactions. Currently, traditional Chinese medicine, as a traditional medicine in China, has been applied in clinical practice for thousands of years and has rich clinical experience in treating HTN-HLP. However, there is no systematic evaluation of the efficacy, safety and improvement of patients’ quality of life. This systematic review and meta-analysis will assess studies of the effects and safety of Chinese herbal medicine (CHM) for HTN-HLP patients. Methods: We will search PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science (ISI), China National Knowledge Infrastructure, Wan fang Database, Chinese Scientific Journals Full-Text Database (VIP) and China Biological Medicine Database from the time when databases were established to 01, February 2021. After a series of screening, randomized controlled trials (RCTs) will be included related to CHM for HTN-HLP. Two researchers will assess the RCTs through the Cochrane bias risk assessment tool. And the evidence grade of the results will be evaluated by GRADEprofiler software. Results: This study will provide a reliable evidence for the efficiency of antihypertensive and reducing blood lipids of CHM for HTN-HLP. Conclusion: We will summarize the methods and provide sufficient evidence to confirm the efficacy and safety of CHM for HTN-HLP. INPLASY registration number: INPLASY2020110144.

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Impairment of autoregulation of optic nerve head blood flow during vitreous surgery in patients with hypertension and hyperlipidemia

Abstract: Our results suggest that HTN and HL impair autoregulation in the vascular component of ONH blood flow during vitrectomy.

Cited by 9 publications

References 45 publications

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy

Chinese herbal medicine for hypertension complicated with hyperlipidemia

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