1979
DOI: 10.1073/pnas.76.1.457
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Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice

Abstract: Several immunologic features were analyzed in mice on a zinc-deficient diet [Zn(-)

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Cited by 288 publications
(106 citation statements)
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“…Low zinc intake can lead to a dramatic loss in immune defense capacity (Fernandes et al 1979) through apoptosis of precursor T-and B-cells, which results in lymphopenia (Fraker 2005). Zinc levels have been linked to cancer, particularly cancer of the prostate (Dhar et al 1973;Franklin 1998, 2000;Platz and Helzlsouer 2001;Bataineh et al 2002;Ho 2004), and to neurodegenerative disease, including amyotrophic lateral sclerosis (Dupuis et al 2004;Ho 2004).…”
Section: Resultsmentioning
confidence: 99%
“…Low zinc intake can lead to a dramatic loss in immune defense capacity (Fernandes et al 1979) through apoptosis of precursor T-and B-cells, which results in lymphopenia (Fraker 2005). Zinc levels have been linked to cancer, particularly cancer of the prostate (Dhar et al 1973;Franklin 1998, 2000;Platz and Helzlsouer 2001;Bataineh et al 2002;Ho 2004), and to neurodegenerative disease, including amyotrophic lateral sclerosis (Dupuis et al 2004;Ho 2004).…”
Section: Resultsmentioning
confidence: 99%
“…A decline in in vivo-generated cytotoxic Tkiller activity to allogenic tumour cells in Zn-deficient mice has been observed. Decreased NK cell activity and responses to cutaneous sensitization have been reported in Zndeficient mice (Fernandes et al, 1979). All these effects of Zn deficiency on immune functions in mice can be reversed with Zn supplementation.…”
Section: Zinc Deficiencymentioning
confidence: 99%
“…The significance of events such as DNA fragmentation or chromosomal condensathis evidence for the induction of necrosis, demonstrating most tion [19,21,31]. Ca 2ϩ /Mg 2ϩ -dependent endonuclease, a candipronounced alterations of thymosin β4 and thymosin β10, date for production of DNA oligonucleosomal ladders, is inhib-GAGE, metallothionein and parathymosin remains to be clariited by zinc [16,32]. Zinc has been shown to inhibit the activity fied.…”
mentioning
confidence: 99%
“…Apoptosis feahave an elevated level of such 'programmed' cell death [15,16]. tures high molecular-mass DNA fragmentation, abnormal chro-…”
mentioning
confidence: 99%