Impairment of fine motor dexterity in mild cognitive impairment and Alzheimer’s disease dementia: association with activities of daily living

Abstract

Objective: Cognitive impairment is a hallmark of mild cognitive impairment (MCI) and Alzheimer's disease dementia (AD). Although the cognitive profile of these patients and its association with activities of daily living (ADLs) is well documented, few studies have assessed deficits in fine motor dexterity and their association with ADL performance. The objective of this research paper is to evaluate fine motor dexterity performance among MCI and AD patients and to investigate its association with different aspects of ADLs. Methods: We assessed normal aging controls, patients with multiple-and single-domain amnestic MCI (aMCI), and patients with mild AD. Fine motor dexterity was measured with the Nine-Hole Peg Test and cognitive functioning by the Mattis Dementia Rating Scale. We analyzed the data using general linear models. Results: Patients with AD or multiple-domain aMCI had slower motor responses when compared to controls. AD patients were slower than those with single-domain aMCI. We found associations between cognition and instrumental ADLs, and between fine motor dexterity and self-care ADLs. Conclusion: We observed progressive slowing of fine motor dexterity along the normal aging-MCI-AD spectrum, which was associated with autonomy in self-care ADLs.

Cognitive Status and Functional Dexterity as Outcome Predictors Following Urinary Diversion: A Combined Retrospective and Prospective Observational Study

“…We found that reduced dexterity as well as poor cognitive function were significantly associated with patient age, which is confirmed by the existing literature on the topic [14,23,24]. As expected and mirrored by the existing literature, dexterity and cognitive function were also inversely correlated [23,24].…”

“…As expected and mirrored by the existing literature, dexterity and cognitive function were also inversely correlated [23,24]. Interestingly, neither dexterity nor cognitive function seem to affect overall HRQoL in UD patients.…”

Motor control assessment of community-dwelling older adults with depressive symptoms

“…The results herein strengthen the need to take careful considerations in defining the requirements of a task into the assessment of motor control of depressed individuals as there are indirect evidences that frontal lobe dysfunctions present a considerable association with the interaction between aging*depression intensity as well with depression intensity itself. Furthermore, ours findings may have clinical implications since the determination of mechanisms that leads to disability in aging are extremely important for the elaboration of preventive measures to help maintain their functional capability 52,53 . It adds evidence to support the claim that the progression of depressive symptoms deserves a closer look when the disorder is established.…”

Clinical Applicability and Psychometric Properties of Manual Function Test for Patients with Stroke

“…In this respect, further reliability study including raters of similar proficiency in MFT may be warranted. Lastly, although fine motor skill is mostly affected by age in non-demented elders (Hoogendam et al 2014), cognitive deficit may influence dexterity (de Paula et al 2016). Since we did not evaluate cognitive function in our healthy participants, any influence by cognitive deficits may not be excluded especially in our older participants.…”