Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Douce, Juliette Le; Maugard, Marianne; Veran, Julien; Matos, Marco; Jégo, Pierrick; Vigneron, Pierre-Antoine; Faivre, Émilie; Toussay, Xavier; Vandenberghe, Michel; Balbastre, Yaël; Piquet, Juliette; Guiot, Elvire; Tran, Nguyet Thuy; Taverna, Myriam; Marinesco, Stéphane; Koyanagi, Ayumi; Furuya, Shigeki; Gaudin-Guérif, Mylène; Goutal, Sébastien; Ghettas, Aurélie; Pruvost, Alain; Bemelmans, Alexis-Pierre; Gaillard, Marie-Claude; Cambon, Karine; Stimmer, Lev; Sazdovitch, Véronique; Duyckaerts, Charles; Hérard, Anne‐Sophie; Delzescaux, Thierry; Hantraye, Philippe; Brouillet, Emmanuel; Cauli, Bruno; Oliet, Stéphane H. R.; Panatier, Aude; Bonvento, Gilles

doi:10.2139/ssrn.3433807

Cited by 26 publications

(39 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reactive microglia may shift astrocyte signaling from physiological to pathological by increasing production of tumor necrosis factor α (TNFα), thus altering synaptic functions and behavior 57 . Functions lost or altered in reactive astrocytes include neurotransmitter and ion buffering in mouse HD models 58 , communication via gap junctions in the sclerotic hippocampus of patients with epilepsy 59 , phagocytic clearance of dystrophic neurites 60 , and metabolic coupling by glycolysis-derived d-serine 61 and lactate 62 in mouse AD models. The excessive release of GABA by reactive astrocytes in AD 63 and Parkinson's disease 64 Transcriptomics and A1-A2 classification.…”

Section: Impact In Cns Diseasesmentioning

confidence: 99%

Reactive astrocyte nomenclature, definitions, and future directions

et al. 2021

Self Cite

View full text Add to dashboard Cite

A full list of affiliations appears at the end of the paper. 'N euroglia' or 'glia' are collective terms describing cells of neuroepithelial (oligodendrocytes, astrocytes, oligodendrocyte progenitor cells, ependymal cells), neural crest (peripheral glia), and myeloid (microglia) origin. Changes in neuroglia associated with diseases of the CNS have been noted, characterized, and conceptualized from the very dawn of neuroglial research. Rudolf Virchow, in a lecture to students and medical doctors in 1858, stressed that 'this very interstitial tissue [that is, neuroglia] of the brain and spinal marrow is one of the most frequent seats of morbid change... ' 1. Changes in the shape, size, or number of glial cells in various pathological contexts have been frequently described by prominent neuroanatomists 2. In particular, hypertrophy of astrocytes was recognized very early as an almost universal sign of CNS pathology: 'the protoplasmic glia elements [that is, astrocytes] are really the elements which exhibit a morbid hypertrophy in pathological conditions' 3. Neuroglial proliferation was thought to accompany CNS lesions, leading to early suggestions that proliferating glia fully replaced damaged neuronal elements 4. Thus, a historical consensus was formed that a change in 'the appearance of neuroglia serves as a delicate indicator of the action of noxious influences upon the central nervous system, ' and the concept of 'reactionary change or gliosis' was accepted 5. While the origin of 'gliosis' is unclear (glia + osis in Greek means 'glial condition or process'; in Latin the suffix-osis acquired the additional meaning of 'disease'; hence 'astrogliosis'

show abstract

Section: Impact In Cns Diseasesmentioning

confidence: 99%

Reactive astrocyte nomenclature, definitions, and future directions

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…This device was then optimized in terms of stability and sensitivity by immobilizing RgDAAO using poly(ethyleneglycol)diglycidyl ether [ 73 ]. This microbiosensor was widely used over the years to investigate the role of D-Ser in the brain under physiological and pathological conditions [ 72 , 80 , 81 , 82 , 83 ].…”

Section: Detection Of D-aas For Biomedical Applicationsmentioning

confidence: 99%

Biosensors for D-Amino Acids: Detection Methods and Applications

Rosini

D’Antona

Pollegioni

2020

IJMS

View full text Add to dashboard Cite

D-enantiomers of amino acids (D-AAs) are only present in low amounts in nature, frequently at trace levels, and for this reason, their biological function was undervalued for a long time. In the past 25 years, the improvements in analytical methods, such as gas chromatography, HPLC, and capillary electrophoresis, allowed to detect D-AAs in foodstuffs and biological samples and to attribute them specific biological functions in mammals. These methods are time-consuming, expensive, and not suitable for online application; however, life science investigations and industrial applications require rapid and selective determination of D-AAs, as only biosensors can offer. In the present review, we provide a status update concerning biosensors for detecting and quantifying D-AAs and their applications for safety and quality of foods, human health, and neurological research. The review reports the main challenges in the field, such as selectivity, in order to distinguish the different D-AAs present in a solution, the simultaneous assay of both L- and D-AAs, the production of implantable devices, and surface-scanning biosensors. These innovative tools will push future research aimed at investigating the neurological role of D-AAs, a vibrant field that is growing at an accelerating pace.

show abstract

“…A large cohort of genes involved in metabolism are induced after traumatic brain injury (Arneson et al, 2018). Impairment of glycolysis-derived metabolites in astrocytes contributes to cognitive deficits in Alzheimer's disease (Le Douce et al, 2020). Previously, mitochondria function and energy metabolism have not been compared directly between human and mouse for any cell type of the central nervous system, to the best of our knowledge.…”

Section: Species Differences In Energy Metabolism In Astrocytes and Omentioning

confidence: 99%

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Pan

Godoy

et al. 2020

Preprint

View full text Add to dashboard Cite

Human-mouse differences are a major barrier in translational research.Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. However, the similarities and differences between human and mouse astrocytes are largely unknown. Combining analyses of acutely purified astrocytes, experiments using serum-free cultures of primary astrocytes, and xenografted chimeric mice, we found extensive conservation in astrocytic gene expression between human and mouse. However, genes involved in defense response and metabolism showed species differences. Human astrocytes exhibited greater susceptibility to oxidative stress than mouse astrocytes, due to differences in mitochondria physiology and detoxification pathways. Mouse astrocytes, but not human astrocytes, activate a molecular program for neural repair under hypoxia. Human astrocytes, but not mouse astrocytes, activate the antigen presentation pathway under inflammatory conditions. These species-dependent properties of astrocytes may contribute to differences between mouse models and human neurological and psychiatric disorders.

show abstract

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Cited by 26 publications

References 7 publications

Reactive astrocyte nomenclature, definitions, and future directions

Reactive astrocyte nomenclature, definitions, and future directions

Biosensors for D-Amino Acids: Detection Methods and Applications

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Contact Info

Product

Resources

About