Impairment of insulin action in non-obese, normal-glucose tolerant, first-degree relatives of Chinese type 2 diabetic patients

Wang, Chun; Tan, Huiwen; Yu, Han‐Qing; Zhang, Xiangxun; Suo, Lixia; Lu, Zhiming; S, Pu; Yu, Yerong

doi:10.1016/j.diabres.2010.10.001

Cited by 9 publications

(7 citation statements)

References 32 publications

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“…However, the common link between adiposity, T2D, HTN, and sedentary lifestyle and a higher propensity for developing AF is unclear. Elevated levels of plasma free fatty acids (FFA) have been associated with increased insulin resistance and T2D 8,9 , HTN 10 , physical inactivity 11 , and inflammation 11 , suggesting that FFA may play an important role in the development of AF. However, the association between plasma FFA and incident AF has not been investigated in the general population including older adults, a group extremely vulnerable to AF.…”

mentioning

confidence: 99%

Plasma Free Fatty Acids and Risk of Atrial Fibrillation (from the Cardiovascular Health Study)

Khawaja

Bartz

et al. 2012

The American Journal of Cardiology

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Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia in clinical practice, affecting approximately 2.3 million people in the USA and 4.5 million people in the European Union. It is unclear whether plasma free fatty acids (FFA) influence the risk of AF among older adults. The aim of this study was to prospectively examine the association between plasma FFA and incident AF in a prospective cohort of 4,175 men and women aged ≥65 years from the Cardiovascular Health Study. Plasma concentrations of FFA were measured in duplicate during the 1992-93 examination. Incident AF was ascertained based on study EKG and hospitalization records during follow up. We used Cox regression to estimate relative risks of AF. The average age at baseline was 74.6 ± 5.1 years. During a mean follow up of 10.0 years, 1,041 new cases of AF occurred. Crude incidence rates of AF were 23.7, 23.3, 23.9, and 29.7 cases/1,000 person-years across consecutive quartiles of plasma FFA. There was a positive association between plasma FFA and the risk of AF. Multivariable adjusted hazard ratios (95% CI) for incident AF were 1.00 (ref), 1.02 (0.85-1.21), 1.05 (0.88-1.26), and 1.29 (1.08-1.55) from lowest to the highest quartile of FFA, respectively. In a secondary analysis restricted to the first five years of follow up, this association persisted. In conclusion, our data show an elevated risk of AF with higher plasma FFA among community dwelling older adults.

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confidence: 99%

Plasma Free Fatty Acids and Risk of Atrial Fibrillation (from the Cardiovascular Health Study)

Khawaja

Bartz

et al. 2012

The American Journal of Cardiology

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“…The Chinese theoretically have less IR compared to obese Westerners [128]. Non-obese, normal-glucose tolerant, first-degree relatives of diabetics have a higher IR [128]. IR was found to be independent of obesity and blood glucose level [128].…”

Section: Metabolic Syndromementioning

confidence: 97%

“…Two thirds of Chinese diabetics had a BMI less than 25 kg/m 2 [127]. The Chinese theoretically have less IR compared to obese Westerners [128]. Non-obese, normal-glucose tolerant, first-degree relatives of diabetics have a higher IR [128].…”

Section: Metabolic Syndromementioning

confidence: 98%

“…Increased plasma free fatty acids (FFA) in obese Chinese people was an important link between obesity and IR, and plasma FFA levels were negatively correlated with insulin sensitivity [129,130,131]. The Chinese exhibited impairment of peripheral insulin sensitivity and elevated circulating FFA levels [128]. For example, in Han Chinese adults living in Shanghai, risk factors for obesity included lower education levels, family history of T2DM, cigarette smoking, high systolic blood pressure, glycemia and dyslipidemia.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…Non-obese, normal-glucose tolerant, first-degree relatives of diabetics have a higher IR [128]. IR was found to be independent of obesity and blood glucose level [128]. Increased plasma free fatty acids (FFA) in obese Chinese people was an important link between obesity and IR, and plasma FFA levels were negatively correlated with insulin sensitivity [129,130,131].…”

Section: Metabolic Syndromementioning

confidence: 99%

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Obesity in China: What are the Causes?

Deneen

Qin²,

Tian³

et al. 2011

CPD

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To address the causes for obesity in all of China is not feasible in a single article. There are hundreds of ethnic groups over a vast number of provinces. The diet and lifestyle of each is different based upon cultural/ethnic traditions and the environment. Several studies mentioned in this review have been done in particular areas and/or on specific population groups with regards to obesity and health risks associated with being overweight. Obesity is a multifactorial disease that is associated with genetic, physiological, environmental, and cultural/traditional perspectives in order to provide a broadened view on this epidemic in China. In this review, we will assess specific obesity gene and environment interactions, childhood obesity etiology, metabolic syndrome, and dietary and behavioral causes. We attempt to discuss obesity issues particularly in the Han Chinese population ranging from children, adolescents, adults to geriatrics.

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Visceral fat mass is always, but adipokines (adiponectin and resistin) are diversely associated with insulin resistance in Chinese type 2 diabetic and normoglycemic subjects

Feng

Ran

et al. 2012

Diabetes Research and Clinical Practice

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Impairment of insulin action in non-obese, normal-glucose tolerant, first-degree relatives of Chinese type 2 diabetic patients

Cited by 9 publications

References 32 publications

Plasma Free Fatty Acids and Risk of Atrial Fibrillation (from the Cardiovascular Health Study)

Plasma Free Fatty Acids and Risk of Atrial Fibrillation (from the Cardiovascular Health Study)

Obesity in China: What are the Causes?

Visceral fat mass is always, but adipokines (adiponectin and resistin) are diversely associated with insulin resistance in Chinese type 2 diabetic and normoglycemic subjects

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