2011
DOI: 10.1530/eje-10-0752
|View full text |Cite
|
Sign up to set email alerts
|

Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth

Abstract: Objective: Intra-uterine growth restriction (IUGR) is related to a higher incidence of type 2 diabetes mellitus. We previously reported reduced adiponectin and increased interleukin 6 (IL6) concentrations in IUGR placentas, which are features of insulin resistance. We aimed to investigate placental insulin receptor (IR) function and activation in human placenta and subsequently the relationships of insulin signalling peptides with placental protein content in IL6, insulin, resistin and adiponectin, and with pa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

5
35
2
1

Year Published

2011
2011
2022
2022

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 45 publications
(43 citation statements)
references
References 40 publications
5
35
2
1
Order By: Relevance
“…5). These findings are important in the context of human pregnancy as dysregulated expression of both up-and down-stream components of the PI3K pathway has been reported in human placenta associated with abnormal fetal growth (44)(45)(46)(47)(48)(49)(50). Furthermore, our study highlights the usefulness of the PI3K α/+ mouse as a tool for investigating the role and mechanisms of maternal-fetal genomic interactions in determining feto-placental phenotype and the programming of subsequent offspring health.…”
Section: Interplay Between Fetal and Maternal Genotypes In Determiningmentioning
confidence: 52%
“…5). These findings are important in the context of human pregnancy as dysregulated expression of both up-and down-stream components of the PI3K pathway has been reported in human placenta associated with abnormal fetal growth (44)(45)(46)(47)(48)(49)(50). Furthermore, our study highlights the usefulness of the PI3K α/+ mouse as a tool for investigating the role and mechanisms of maternal-fetal genomic interactions in determining feto-placental phenotype and the programming of subsequent offspring health.…”
Section: Interplay Between Fetal and Maternal Genotypes In Determiningmentioning
confidence: 52%
“…It is well established that maternal insulin is dysregulated in pregnancies complicated by diabetes, obesity, undernutrition, and preeclampsia, and insulin resistance also occurs in the placentas from diabetic, preeclamptic, and growth-restricted pregnancies (Colomiere et al, 2009;Rademacher et al, 2007;Scioscia et al, 2006;Street et al, 2011). Maternal infection during pregnancy increases cytokines within the placenta and is predicted to disrupt insulin signaling due to the inhibitory effects of cytokines on insulin action (Aguirre et al, 2002;Sykiotis and Papavassiliou, 2001;Tanti and Jager, 2009).…”
Section: A Common Programmatic Pathwaymentioning
confidence: 99%
“…In the human placenta, GSK-3 is activated in pregnancies complicated by fetal growth restriction [96], but the underlying mechanisms remain unclear [96,104,105]. In addition, placental GSK-3 is activated in maternal nutrient restriction in the baboon, which is associated with downregulation of placental nutrient transporters, decreased circulating fetal levels of amino acids, and fetal growth restriction [27].…”
Section: Placental Signaling Pathways Responding To Altered Metabolismentioning
confidence: 99%
“…Both maternal undernutrition and overnutrition alter circulating levels of hormones and factors including insulin, IGF-I, adiponectin, and leptin. Mechanistic target of rapamycin complex 1 is activated by insulin and IGF-I, and placental insulin/IGF-I signaling is inhibited in IUGR [96,104,105]. In addition, leptin signaling activates and cortisol inhibits mTORC1 [2].…”
Section: The Role Of Mtor In Placental Nutrient Sensingmentioning
confidence: 99%