Impairment of mitochondrial function by particulate matter: Implications for the brain

Chew, Sweelin; Kołosowska, Natalia; Saveleva, Liudmila; Malm, Tarja

doi:10.1016/j.neuint.2020.104694

Cited by 54 publications

(44 citation statements)

References 166 publications

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“…Most of air quality studies reported that short-term exposure to particulate matter, PM 2.5 can be related to acute lower respiratory infection (Bates et al 2018 ; Li et al 2020 ; Liu et al 2020a ; Martins and Carrilho 2020 ; Tan et al 2019 ; Wu 2019 ). However, not only PM 2.5 , but PM 10 was also found to have a significant relation with hospitalization due to the respiratory illness and pneumonia (Cheng et al 2020 ; Chew et al 2020 ; Ge et al 2018 ; Liu et al 2020b ; Luong et al 2016 ; Mäkelä et al 2019 ; Nephew et al 2020 ; Pun et al 2017 ; De Rooij et al 2019 ; Zhang et al 2019a ). Similarly, several studies had been conducted to find the association of air pollutants such as NO 2 , SO 2 , and other particulate matters with the increased risk of respiratory infections and mortality rates (Ã et al 2005 ; Ashikin et al 2014 ; Galy-lacaux et al 2016 ; Lau et al 2020 ; Mason et al 2019 ; Pan et al 2010 ; Sahoo et al 2017 ; Wang and Su 2020 ; Yang et al 2020b ).…”

Section: Discussionmentioning

confidence: 99%

Significance between air pollutants, meteorological factors, and COVID-19 infections: probable evidences in India

Sahoo

2021

Environ Sci Pollut Res

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Graphical abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease represents the causative agent with a potentially fatal risk which is having great global human health concern. Earlier studies suggested that air pollutants and meteorological factors were considered as the risk factors for acute respiratory infection, which carries harmful pathogens and affects the immunity. The study intended to explore the correlation between air pollutants, meteorological factors, and the daily reported infected cases caused by novel coronavirus in India. The daily positive infected cases, concentrations of air pollutants, and meteorological factors in 288 districts were collected from January 30, 2020, to April 23, 2020, in India. Spearman’s correlation and generalized additive model (GAM) were applied to investigate the correlations of four air pollutants (PM 2.5 , PM 10 , NO 2 , and SO 2 ) and eight meteorological factors (Temp, DTR, RH, AH, AP, RF, WS, and WD) with COVID-19-infected cases. The study indicated that a 10 μg/m 3 increase during (Lag0-14) in PM 2.5 , PM 10 , and NO 2 resulted in 2.21% (95%CI: 1.13 to 3.29), 2.67% (95% CI: 0.33 to 5.01), and 4.56 (95% CI: 2.22 to 6.90) increase in daily counts of Coronavirus Disease 2019 (COVID 19)-infected cases respectively. However, only 1 unit increase in meteorological factor levels in case of daily mean temperature and DTR during (Lag0-14) associated with 3.78% (95%CI: 1.81 to 5.75) and 1.82% (95% CI: -1.74 to 5.38) rise of COVID-19-infected cases respectively. In addition, SO 2 and relative humidity were negatively associated with COVID-19-infected cases at Lag0-14 with decrease of 7.23% (95% CI: -10.99 to -3.47) and 1.11% (95% CI: -3.45 to 1.23) for SO 2 and for relative humidity respectively. The study recommended that there are significant correlations between air pollutants and meteorological factors with COVID-19-infected cases, which substantially explain the effect of national lockdown and suggested positive implications for control and prevention of the spread of SARS-CoV-2 disease.

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Section: Discussionmentioning

confidence: 99%

Significance between air pollutants, meteorological factors, and COVID-19 infections: probable evidences in India

Sahoo

2021

Environ Sci Pollut Res

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“…These organelles are targeted by environmental pollutants, including PM, NO 2 , and O 3 , through a variety of mechanisms. 125,[202][203][204] Pollutant-mediated mitochondrial dysfunction also promotes apoptosis, which could affect viral replication and immune surveillance in SARS-CoV-2 infection (Fig. 2).…”

Section: Pollutant Exposure Interferes With Mitochondrial Function Anmentioning

confidence: 99%

SARS‐CoV‐2 infection, COVID‐19 pathogenesis, and exposure to air pollution: What is the connection?

Woodby

Arnold

Valacchi

2020

Annals of the New York Academy of Sciences

130

113

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Exposure to air pollutants has been previously associated with respiratory viral infections, including influenza, measles, mumps, rhinovirus, and respiratory syncytial virus. Epidemiological studies have also suggested that air pollution exposure is associated with increased cases of SARS-CoV-2 infection and COVID-19-associated mortality, although the molecular mechanisms by which pollutant exposure affects viral infection and pathogenesis of COVID-19 remain unknown. In this review, we suggest potential molecular mechanisms that could account for this association. We have focused on the potential effect of exposure to nitrogen dioxide (NO 2), ozone (O 3), and particulate matter (PM) since there are studies investigating how exposure to these pollutants affects the life cycle of other viruses. We have concluded that pollutant exposure may affect different stages of the viral life cycle, including inhibition of mucociliary clearance, alteration of viral receptors and proteases required for entry, changes to antiviral interferon production and viral replication, changes in viral assembly mediated by autophagy, prevention of uptake by macrophages, and promotion of viral spread by increasing epithelial permeability. We believe that exposure to pollutants skews adaptive immune responses toward bacterial/allergic immune responses, as opposed to antiviral responses. Exposure to air pollutants could also predispose exposed populations toward developing COIVD-19associated immunopathology, enhancing virus-induced tissue inflammation and damage.

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“…Most of air quality studies reported that short-term exposure to particulate matter, PM 2.5 can be related to acute lower respiratory infection (Bates et al, 2018;Martins and Carrilho, 2020;Tan et al, 2019;Wu, 2019). However, not only PM 2.5 , but PM 10 was also found to be have a significant relation with hospitalization due to the respiratory illness and pneumonia (Cheng et al, 2020;Chew et al, 2020;Ge et al, 2018;Luong et al, 2016;Mäkelä et al, 2019;Nephew et al, 2020;Pun et al, 2017;Rooij et al, 2019;.…”

mentioning

confidence: 99%

Significance between Air pollutants, Meteorological Factors and COVID-19 Infections: Probable Evidences in India

Sahoo

2020

Preprint

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SARS-CoV-2 (Coronavirus) disease represents the causative agent with a potentially fatal risk which is having great global human health concern. Earlier studies suggested that air pollutants and meteorological factors were considered as the risk factors for acute respiratory infection, which carries harmful pathogens and affects the immunity. The study intended to explore the correlation between air pollutants, meteorological factors and the daily reported infection cases caused by novel coronavirus in India. The daily positive infected cases, air pollution and meteorological factors in 288 districts were collected from January 30, 2020 to April 23, 2020 in India. Speraman’s correlation and generalised additive model were applied to investigate the correlations of four air pollutants (PM2.5, PM10, NO2 and SO2) and eight meteorological factors (Temp, DTR, RH, AH, AP, RF, WS and WD) with COVID-19 infected cases. The study indicated that a 10 µg/m3 increase during (Lag0-14) in PM2.5, PM10 and NO2 was resulted in 2.21% (95%CI: 1.13 to 3.29), 2.67% (95% CI: 0.33 to 5.01) and 4.56 (95% CI: 2.22 to 6.90) increase in daily counts of COVID 19 infected cases respectively. However, only 1 unit increase in meteorological factor levels in case of daily mean temperature and DTR during (Lag0-14) associated with 3.78% (95%CI: 1.81 to 5.75) and 1.82% (95% CI: -1.74 to 5.38) rise of COVID-19 infected cases respectively. In addition, SO2 and relative humidity were negatively associated with COVID-19 infected cases at Lag0-14 with decrease of 7.23% (95% CI: -10.99 to -3.47) and 1.11% (95% CI: -3.45 to 1.23) for SO2 and for relative humidity respectively. The study recommended that there is significant relationship between air pollutants and meteorological factors with COVID-19 infected cases, which substantially explain the effect of national lockdown and suggested positive implications for control and prevention of the spread of SARS-CoV-2 disease.

show abstract

Impairment of mitochondrial function by particulate matter: Implications for the brain

Cited by 54 publications

References 166 publications

Significance between air pollutants, meteorological factors, and COVID-19 infections: probable evidences in India

Significance between air pollutants, meteorological factors, and COVID-19 infections: probable evidences in India

SARS‐CoV‐2 infection, COVID‐19 pathogenesis, and exposure to air pollution: What is the connection?

Significance between Air pollutants, Meteorological Factors and COVID-19 Infections: Probable Evidences in India

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