Impairment of motor planning in patients with Parkinson's disease: evidence from ideomotor apraxia testing.

Goldenberg, Georg; Wimmer, A.; Auff, Eduard; Schnaberth, G

doi:10.1136/jnnp.49.11.1266

Cited by 86 publications

(43 citation statements)

References 17 publications

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“…The high frequency of pantomimic apraxia in HD, observed in our present study and in those by Hodl et al [17] and Hamilton et al [16] , is higher than has been observed previously in several studies of ideomotor limb apraxia in patients with other diseases of the basal ganglia [30][31][32][33][34] . For instance, Leiguarda and Marsen [35] reported pantomimic movement apraxia in 2/8 patients with Parkinson's disease and 2/5 patients with progressive supranuclear palsy.…”

Section: Discussioncontrasting

confidence: 56%

Impaired Ideomotor Limb Apraxia in Cortical and Subcortical Dementia: A Comparison of Alzheimer’s and Huntington’s Disease

Holl¹,

Ille

Wilkinson

et al. 2011

Neurodegener Dis

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Background: Although ideomotor limb apraxia is often considered to occur only in dementia with cortical involvement like Alzheimer’s disease (AD), it is also frequently seen in dementia with subcortical degeneration like Huntington’s disease (HD). Methods: To assess the occurrence of ideomotor limb apraxia, 46 patients with HD (27 men) and 37 patients with AD (16 men), matched for cognitive performance, were assessed with an apraxia test battery containing tests of the imitation of meaningless hand and finger gestures, the performance of meaningful gestures and of pantomimic movements. Results: There was a high frequency of ideomotor limb apraxia in both AD and HD patients. For the assessment of hands’ imitation 13.5% of the AD patients and 41.3% of the HD patients were apraxic, for fingers’ imitation 21.6% (AD) and 41.3% (HD) were apraxic, for gestures 27.0% (AD) and 32.6% (HD), and for the assessment of pantomimic movements 24.3% (AD) and 52.2% (HD) showed apraxia. In the AD patients, disease severity was related to the occurrence of apraxia. Conclusions: Ideomotor limb apraxia is a common sign in both groups of patients, occurring in a high percentage. For particular neuropsychological deficits, including ideomotor limb apraxia, a division of dementia in a subcortical and cortical subtype seems to be clinically not meaningful.

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Section: Discussioncontrasting

confidence: 56%

Impaired Ideomotor Limb Apraxia in Cortical and Subcortical Dementia: A Comparison of Alzheimer’s and Huntington’s Disease

Holl¹,

Ille

Wilkinson

et al. 2011

Neurodegener Dis

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“…This finding may reflect the Parkinson disorder in design and execution of motor plans (Goldenberg et al, 1986) so that these patients are unable to learn new movement patterns.…”

Section: Discussionmentioning

confidence: 89%

Physical activity and sports in patients suffering from Parkinson's disease in comparison with healthy seniors

Fertl

Doppelbauer

Auff

1993

J Neural Transm Gen Sect

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Physical activity during lifetime was investigated among 32 Parkinson patients (age 65.6 +/- 8.1 yrs, mean +/- SD) retrospectively by means of a structured interview. Data were compared with 31 healthy controls (age 61.7 +/- 5.8 yrs). An objective score was obtained by presenting a list of all kinds of sports, subjective estimation of physical activity was done by visual analogous scales. Until the occurrence of the first symptoms (mean = 58.5 yrs) the patients did not differ from controls. During the course of disease a striking reduction in physical activity but no complete abandonment of sports was found. Swimming, hiking and gymnastics were the favoured sports in both groups. Learning of new sports seemed to be impossible for the patients.

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“…[45][46][47] Likewise, apraxia is not a common feature of PD-D, 39 although impaired ideomotor praxis was described in an unselected population of patients with PD. 48 Many of the described language deficits (such as impaired verbal fluency, naming difficulty), however, may not reflect a true involvement of language functions but may be related to the dysexecutive syndrome, i.e., impaired self-generated search strategies due to executive dysfunction. 30,47 Behavioural and personality changes are frequent in patients with PD-D. All patients with PD-D had clinical and historical evidence of personality changes, 29 depressive symptoms were especially common, more so than in patients with AD.…”

Section: S64mentioning

confidence: 98%

What causes mental dysfunction in Parkinson's disease?

2003

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Abstract:Parkinson's disease (PD) is frequently associated with mental dysfunction. Domain-specific cognitive deficits are ubiquitous, and although they may not be clinically apparent in all patients, they are demonstrable by neuropsychological testing. Dementia is less frequent but is present significantly more in PD patients than in controls, with a cumulative prevalence rate up to 40% and up to six-fold increased incidence. Cognitive impairment mainly involves executive and visuospatial functions; memory is secondarily impaired with relatively preserved recognition. Qualitatively, the neuropsychological profile of dementia encompasses the same type of deficits found in nondemented PD patients. The dementia seen in PD, therefore, can be described as a dysexecutive syndrome combined with visuospatial dysfunction and behavioural symptoms. Dopaminergic, noradrenergic, serotoninergic, and cholinergic deficits have all been described as the underlying neurochemical impairment, but the strongest evidence exists for a cholinergic dysfunction. Involvement of brainstem nuclei, limbic structures, and cerebral cortex have been suggested as the site, and Lewy body (LB) degeneration and Alzheimer-type changes as the type of pathology underlying the mental dysfunction in PD. Although there is still some controversy as to the site and type of pathology, recent evidence suggests that LB-type degeneration in limbic structures and cerebral cortex, with consequent synaptic and cell loss, is the main pathological state associated with dementia in PD.

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Impairment of motor planning in patients with Parkinson's disease: evidence from ideomotor apraxia testing.

Cited by 86 publications

References 17 publications

Impaired Ideomotor Limb Apraxia in Cortical and Subcortical Dementia: A Comparison of Alzheimer’s and Huntington’s Disease

Impaired Ideomotor Limb Apraxia in Cortical and Subcortical Dementia: A Comparison of Alzheimer’s and Huntington’s Disease

Physical activity and sports in patients suffering from Parkinson's disease in comparison with healthy seniors

What causes mental dysfunction in Parkinson's disease?

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