Impairment of osteophyte formation in hyperglycemic patients with type II diabetes mellitus and knee osteoarthritis

Horn, Claire; Bradley, John; Brandt, Kenneth D.; Kreipke, Donald L.; Slowman, Sally D.; Kalasinski, Lorrie A.

doi:10.1002/art.1780350313

Cited by 23 publications

(24 citation statements)

References 22 publications

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“…These 5 prospective cohort studies involved much higher number of 83 857 subjects compared with the 2782 subjects involved in the positive studies with prospective cohort design (table 2). Within these five prospective cohort studies, four reported negative associations between DM and OA 9 12 13 33…”

Section: Resultsmentioning

confidence: 99%

Diabetes mellitus is not a risk factor for osteoarthritis

Khor

Hong

et al. 2020

RMD Open

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BackgroundAssociation between diabetes mellitus (DM) and risk of osteoarthritis (OA) can be confounded by body mass index (BMI), a strong risk factor for both conditions. We evaluate the association between DM or hyperglycaemia with OA using systematic review and meta-analysis.MethodsWe searched PubMed and Web of Science databases in English for studies that gave information on the association between DM and OA. Two meta-analysis models were conducted to address: (1) risk of DM comparing subjects with and without OA and (2) risk of OA comparing subjects with and without DM. As far as available, risk estimates that adjusted for BMI were used.Results31 studies with a pooled population size of 295 100 subjects were reviewed. 16 and 15 studies reported positive associations and null/ negative associations between DM and OA. 68.8% of positive studies had adjusted for BMI, compared with 93.3% of null/negative studies. In meta-analysis model 1, there was an increase prevalence of DM in subjects with OA compared with those without (OR 1.56, 95% CI 1.28 to 1.89). In meta-analysis model 2, there was no increased risk of OA (OR 1.14, 95% CI 0.98 to 1.33) in subjects with DM compared with those without, regardless of gender and OA sites. Comparing subjects with DM to those without, an increased risk of OA was noted in cross-sectional studies, but not in case-control and prospective cohort studies.ConclusionsThis meta-analysis does not support DM as an independent risk factor for OA. BMI was probably the most important confounding factor.

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Section: Resultsmentioning

confidence: 99%

Diabetes mellitus is not a risk factor for osteoarthritis

Khor

Hong

et al. 2020

RMD Open

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“…Tumor necrosis factor-alpha (TNFα) and interleukin (IL)-1β from lipopolysaccharide-stimulated macrophages are lower in diabetic mice compared to control mice36. In a small case-control study, subchondral sclerosis and osteophytes on knee radiography were less common in subjects with diabetes compared to controls matched by age, weight, and duration of OA symptoms, suggesting that a diabetes state may attenuate the chondro- and osteo-genesis required for osteophyte formation in OA37.…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study

Leung

Allen

Ang

et al. 2017

Sci Rep

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Association between diabetes mellitus (diabetes) and risk of knee osteoarthritis (KOA) is confounded by high body mass index (BMI), a strong risk factor for both conditions. We evaluated the association between diabetes and incidence of total knee replacement (TKR) due to severe KOA in the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese men and women, aged 45–74 years at recruitment in 1993–1998, and re-interviewed in 1999–2004. Height, weight, lifestyle factors and history of diabetes were obtained through in-person interviews at recruitment and re-interview. Incident cases of TKR were identified via record linkage with nationwide hospital discharge database. Subjects with/without prevalent diabetes had comparable BMI (24.0 kg/m2 versus 23.0 kg/m2). After an average of 14-years, 1,973 subjects had TKR attributable to KOA. Compared to subjects without diabetes, hazard ratio (HR) of TKR for subjects with diabetes was 0.63 [95% confidence interval (CI), 0.52–0.75] after controlling for BMI and other risk factors. An inverse association was also observed between incident diabetes at re-interview and subsequent risk of TKR (HR = 0.74; 95% CI = 0.58–0.94). The inverse diabetes-TKR risk association was similar by gender and across three categories of BMI. Our study does not support diabetes as a risk factor of KOA.

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“…We have previously shown that the phenotypic appearance of radiographic knee osteoarthritis is different in patients with diabetes than in those without diabetes, with the patients with diabetes exhibiting less osteophytosis. 41 We speculated that the difference was due to less effect of insulin on new bone formation in osteoarthritis joints of patients with diabetes. Our study suggests a racial difference in the phenotype of radiographic knee osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for early radiographic changes of tibiofemoral osteoarthritis

Mazzuca¹,

Brandt

Katz

et al. 2007

Annals of the Rheumatic Diseases

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Objective: To evaluate the risk factors for early radiographic changes of knee osteoarthritis. Methods: Subjects (n = 114) with unilateral or bilateral grade 0-1 knee osteoarthritis underwent x ray examination of the knees (semiflexed anteroposterior view) and assessment with the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index at baseline and 30 months later. Severity of joint space narrowing (JSN) and osteophytosis were graded in randomly ordered serial radiographs by two readers, blinded to the sequence of the films, using standard pictorial atlases. Results: The odds of an initial appearance of radiographic features of knee osteoarthritis at month 30 were more than threefold greater in African Americans than in whites (osteophytosis: odds ratio (OR) 3.30, 95% confidence interval (CI) 1.04 to 10.54; JSN: OR 3.49, 95% CI 1.16 to 10.68). In addition, the appearance of osteophytosis was positively related to baseline stiffness (OR 1.91/2.1 points on the 2-10 WOMAC scale, 95% CI 1.29 to 2.82). Conclusions:The distinction between incident and established, but early, radiographic knee osteoarthritis is difficult because of the limits to which all possible evidence of the disease can be ruled out in a conventional baseline knee radiograph. Nonetheless, our finding that African Americans were at greater risk of early osteophytosis and JSN than other subjects differs from the results of our previous analysis of risk factors for progressive knee osteoarthritis in the same subjects. The development of osteophytes also was associated with joint stiffness. Future investigations should focus on the systemic and local influences that these ostensible risk factors represent.

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Impairment of osteophyte formation in hyperglycemic patients with type II diabetes mellitus and knee osteoarthritis

Cited by 23 publications

References 22 publications

Diabetes mellitus is not a risk factor for osteoarthritis

Diabetes mellitus is not a risk factor for osteoarthritis

Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study

Risk factors for early radiographic changes of tibiofemoral osteoarthritis

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