Impairment of perinatal hypoxia–ischemia to the preterm brainstem

Jiang, Ze D.; Brosi, Dorothea M.; Chen, C.; Wilkinson, A

doi:10.1016/j.jns.2009.07.029

Cited by 14 publications

(6 citation statements)

References 39 publications

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“…perinatal HI may be particularly vulnerable to physiological changes (66). Thus, our finding corroborates the findings of others in that the more central part (III-V interval) of the auditory pathway is more affected by HI insult than the more peripheral part (I-III interval) of the pathway (33). The progressive increase in ABR latencies and interpeak intervals may be attributed to a cumulative decrease in the efficacy of synaptic transmission at high stimulus rates, resulting in prolonged synaptic delays along the brainstem auditory pathway (35).…”

Section: Discussionsupporting

confidence: 91%

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

et al. 2015

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Maturation of the auditory pathway is dependent on the central nervous system myelination and it can be affected by pathologies such as neonatal hypoxic ischemic (HI) encephalopathy. Our aim was to evaluate the functional integrity of the auditory pathway and to visualize, by histological and cellular methods, the damage to the brainstem using a neonatal rat model of HI brain injury. To carry out this morphofunctional evaluation, we studied the effects of the administration of the antioxidants nicotine, melatonin, resveratrol and docosahexaenoic acid after hypoxia-ischemia on the inferior colliculus and the auditory pathway. We found that the integrity of the auditory pathway in the brainstem was altered as a consequence of the HI insult. Thus, the auditory brainstem response (ABR) showed increased I-V and III-V wave latencies. At a histological level, HI altered the morphology of the inferior colliculus neurons, astrocytes and oligodendricytes, and at a molecular level, the mitochondria membrane potential and integrity was altered during the first hours after the HI and reactive oxygen species (ROS) activity is increased 12 h after the injury in the brainstem. Following antioxidant treatment, ABR interpeak latency intervals were restored and the body and brain weight was recovered as well as the morphology of the inferior colliculus that was similar to the control group. Our results support the hypothesis that antioxidant treatments have a protective effect on the functional changes of the auditory pathway and on the morphological damage which occurs after HI insult.

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Section: Discussionsupporting

confidence: 91%

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

et al. 2015

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“…Neonatal encephalopathy has been linked to hearing loss and communication deficits such as poor speech discrimination [17]. Experimental and clinical studies have also demonstrated a strong susceptibility of brainstem auditory neurons to asphyxia and hypoxic-ischemic insult, but the molecular mechanisms for this sensitivity are not well understood [18][19][20][21][22]. Oxygen homeostasis is regulated by hypoxia-inducible factor 1a (Hif1a), which is involved in regulating the transcription of target genes that mediate the adaptation of cells and tissues to oxygen shortage [23].…”

Section: Introductionmentioning

confidence: 99%

Defining the relationship between maternal care behavior and sensory development in Wistar rats: Auditory periphery development, eye opening and brain gene expression

et al. 2020

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Defining the relationship between maternal care, sensory development and brain gene expression in neonates is important to understand the impact of environmental challenges during sensitive periods in early life. In this study, we used a selection approach to test the hypothesis that variation in maternal licking and grooming (LG) during the first week of life influences sensory development in Wistar rat pups. We tracked the onset of the auditory brainstem response (ABR), the timing of eye opening (EO), middle ear development with micro-CT X-ray tomography, and used qRT-PCR to monitor changes in gene expression of the hypoxia-sensitive pathway and neurotrophin signaling in pups reared by low-LG or high-LG dams. The results show the first evidence that the transcription of genes involved in the hypoxia-sensitive pathway and neurotrophin signaling is regulated during separate sensitive periods that occur before and after hearing onset, respectively. Although the timing of ABR onset, EO, and the relative mRNA levels of genes involved in the hypoxia-sensitive pathway did not differ between pups from different LG groups, we found statistically significant increases in the relative mRNA levels of four genes involved in neurotrophin signaling in auditory brain regions from pups of different LG backgrounds. These results suggest that sensitivity to hypoxic challenge might be widespread in the auditory system of neonate rats before hearing onset, and that maternal LG may affect the transcription of genes involved in experience-dependent neuroplasticity.

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“…In human subjects, the BAER has been used as an important tool to examine functional integrity and development of the brainstem auditory pathway in babies after perinatal hypoxia or hypoxia-ischaemia [2,4,[19][20][21][22][23][24][25][26]. In experimental animal models, the BAER has been shown that to be is very sensitive to arterial blood oxygen levels and acute hypoxia or hypoxia-ischaemia [4,[27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Brainstem Auditory Function at Term Between Premature Babies with Neonatal Chronic Sublethal Hypoxia and Those Without the Hypoxia

Jiang¹

2021

AJPN

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Considerable evidence suggests that neurodevelopmental disorders in babies born very prematurely often link to hypoxic events during the perinatal period. These babies often undergo chronic or prolonged periods of sublethal hypoxia [12]. In babies born very prematurely, a typical clinical problem that is associated with CSH is chronic lung disease (CLD). It is a major lung disease that causes hypoxaemia of pulmonary origin in babies who are born very prematurely [13][14][15][16][17]. Babies who suffer CLD often

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Impairment of perinatal hypoxia–ischemia to the preterm brainstem

Cited by 14 publications

References 39 publications

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

Defining the relationship between maternal care behavior and sensory development in Wistar rats: Auditory periphery development, eye opening and brain gene expression

Comparison of Brainstem Auditory Function at Term Between Premature Babies with Neonatal Chronic Sublethal Hypoxia and Those Without the Hypoxia

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