Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy

Fontanetti, P.A.; Lucca, R.C. De; Mandalunis, Patricia; Vermouth, Nelia T.

doi:10.1016/j.archoralbio.2013.08.003

Cited by 3 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been well documented that prenatal stress in rats is associated with growth retardation, low birth weight [Mueller and Bale, 2006] as well as a delay in neurobehavioral development [Ward et al, 2000] and first mandibular molar eruption [Fontanetti et al, 2013]. In keeping with studies reported in the literature, our results showed significantly lower body weight in both the 3-dayold and 15-day-old LL pups than in the corresponding controls.…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies conducted at our laboratory also showed alterations in endochondral ossification in rats treated with arsenic [Aybar Odstrcil et al, 2010] and lithium carbonate [Lewicki et al, 2006]. Previously, we used the same experimental model of constant light to assess tooth eruption; the results showed that prenatal exposure to constant light caused a delay in tooth eruption associated with a decrease in the number of osteoclasts and in TRAP expression by osteoclasts and preosteoclasts [Fontanetti et al, 2013]. Interestingly, although exposure to the same stressor impaired tibial endochondral ossification in this study, we did not observe any alteration in the number of osteoclasts or in the expression of TRAP in the tibiae.…”

Section: Discussionmentioning

confidence: 91%

“…days 10-20 of gestation. The constant-light model was validated in previous studies performed at our laboratory demonstrating that constant light initiated on day 10 of gestation interrupts maternal fetal synchronization, which begins on days 11-12 of gestation [Bellavía et al, 1996;Cisternas et al, 2010;Fontanetti et al, 2013].…”

Section: Animal Groupsmentioning

confidence: 99%

“…A previous work conducted at our laboratory showed a delay in the eruption of the first mandibular molar associated with osteoclast-mediated bone resorption in pups born to mothers chronically exposed to constant light [Fontanetti et al, 2013]. Tooth eruption is associated with the jawbone, which develops through direct/intramembranous ossification.…”

mentioning

confidence: 99%

“…The central components of the stress response are the sympathetic nervous system and the hypothalamic-pituitaryadrenal axis [Tsigos and Chrousos, 2002]. It is known that continuous constant light can be used as a chronic stressor in different animal models [Semenchenko et al, 2004;Alterman et al, 2012;Fontanetti et al, 2013]. When constant light is applied as a chronic stressor, it desynchronizes the individual neurons of the principal pacemaker in adult rodents [Ohta et al, 2005].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Prenatal Exposure to Continuous Constant Light Alters Endochondral Ossification of the Tibiae of Rat Pups

Fontanetti

Nervegna

Vermouth

et al. 2014

Cells Tissues Organs

View full text Add to dashboard Cite

Clinical and experimental studies suggest that prenatal exposure to stress can impact the growth and development of offspring. The effect of prenatal exposure to constant light, applied as a chronic stressor, on endochondral ossification of the tibiae of 3-day-old and 15-day-old pups was histomorphometrically evaluated. Pregnant rats were divided into 2 groups: mothers chronically exposed to a 12:12-hour light/light cycle (LL) and control mothers maintained on a 12:12-hour light/dark cycle on days 10-20 of pregnancy. On postnatal days 3 and 15, the pups were weighed and euthanized. The tibiae were resected and histologically processed to obtain sections for hematoxylin and eosin staining (HE) and tartrate-resistant acid phosphatase (TRAP) histochemistry, in order to perform histomorphometric determinations. The data were statistically analyzed. A significant decrease in hypertrophic cartilage thickness was observed in the tibiae of the 3-day-old (LL: 0.134 ± 0.02 vs. controls: 0.209 ± 0.023 mm; p < 0.01) and 15-day-old (LL: 23.32 ± 3.98 vs. controls: 22.96 ± 1.93 mm; p < 0.05) prenatally stressed pups. The subchondral bone volume was significantly lower in the tibiae of the 3-day-old LL pups (38.83 ± 6.14%) than in the controls (62.83 ± 10.67%; p < 0.01). The decrease in subchondral bone volume and hypertrophic cartilage thickness shows that the normal growth process of the tibia is impaired in prenatally stressed pups.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 91%

Section: Animal Groupsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Prenatal Exposure to Continuous Constant Light Alters Endochondral Ossification of the Tibiae of Rat Pups

Fontanetti

Nervegna

Vermouth

et al. 2014

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

Numerical investigations of bone remodelling around the mouse mandibular molar primordia

Chen

Keilig

et al. 2019

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

Developmental programming of tissue-resident macrophages

Viola,

Franco Taveras,

Mass

2024

Front. Immunol.

View full text Add to dashboard Cite

Macrophages are integral components of the innate immune system that colonize organs early in development and persist into adulthood through self-renewal. Their fate, whether they are replaced by monocytes or retain their embryonic origin, depends on tissue type and integrity. Macrophages are influenced by their environment, a phenomenon referred to as developmental programming. This influence extends beyond the local tissue microenvironment and includes soluble factors that can reach the macrophage niche. These factors include metabolites, antibodies, growth factors, and cytokines, which may originate from maternal diet, lifestyle, infections, or other developmental triggers and perturbations. These influences can alter macrophage transcriptional, epigenetic, and metabolic profiles, affecting cell-cell communication and tissue integrity. In addition to their crucial role in tissue immunity, macrophages play vital roles in tissue development and homeostasis. Consequently, developmental programming of these long-lived cells can modulate tissue physiology and pathology throughout life. In this review, we discuss the ontogeny of macrophages, the necessity of developmental programming by the niche for macrophage identity and function, and how developmental perturbations can affect the programming of macrophages and their subtissular niches, thereby influencing disease onset and progression in adulthood. Understanding these effects can inform targeted interventions or preventive strategies against diseases. Finally, understanding the consequences of developmental programming will shed light on how maternal health and disease may impact the well-being of future generations.

show abstract

Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy

Cited by 3 publications

References 48 publications

Prenatal Exposure to Continuous Constant Light Alters Endochondral Ossification of the Tibiae of Rat Pups

Prenatal Exposure to Continuous Constant Light Alters Endochondral Ossification of the Tibiae of Rat Pups

Numerical investigations of bone remodelling around the mouse mandibular molar primordia

Developmental programming of tissue-resident macrophages

Contact Info

Product

Resources

About