Impairment of sleep-related memory consolidation in schizophrenia: relevance of sleep spindles?

Göder, Robert; Graf, Anna; Ballhausen, Felix; Weinhold, Sara Lena; Baier, Paul Christian; Junghanns, Klaus; Prehn-Kristensen, Alexander

doi:10.1016/j.sleep.2014.12.022

Cited by 109 publications

(94 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We report N2 findings based on prior studies showing N2 spindle abnormalities in schizophrenia and correlations of N2 spindle activity with sleep-dependent memory consolidation 4,7,11 .…”

Section: Resultsmentioning

confidence: 99%

“…We were also not able to examine the coordination of SWs and spindles with hippocampal ripples since ripples are not seen on scalp recordings. Hippocampal involvement is more associated with sleep-dependent declarative than procedural memory, which is also impaired in schizophrenia 11 . Future work will investigate the contribution of SW-spindle coordination to declarative memory deficits.…”

Section: Discussionmentioning

confidence: 99%

“…Recent work places deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia and implicates reduced sleep spindles, a defining electroencephalographic (EEG) feature of Stage 2 non-rapid eye movement sleep (N2), as a potentially treatable mechanism 4 . Schizophrenia patients have deficient sleep-dependent consolidation of both procedural [5][6][7][8][9][10] and declarative 11 memory that, in some studies, correlates with reduced sleep spindle density (spindles per minute) and number 10,11 . These relations are consistent with a large basic literature showing that spindle activity correlates with measures of intelligence and sleep-dependent memory consolidation 12 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Demanuele

Bartsch

Baran

et al. 2016

Sleep

View full text Add to dashboard Cite

General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Demanuele et al., 2016 1 This study is not a clinical trial. Demanuele et al., 2016 3 Coordination of Slow Waves with Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia AbstractStudy Objectives: Schizophrenia patients have correlated deficits in sleep spindle density and sleep-dependent memory consolidation. In addition to spindle density, memory consolidation is thought to rely on the precise temporal coordination of spindles with slow waves (SWs). We investigated whether this coordination is intact in schizophrenia and its relation to motor procedural memory consolidation.Methods: Twenty-one chronic medicated schizophrenia patients and 17 demographicallymatched healthy controls underwent two nights of polysomnography with training on the finger tapping motor sequence task (MST) on the second night and testing the following morning. We detected SWs (0.5-4Hz) and spindles during non-rapid eye-movement (NREM) sleep. We measured SW-spindle phase-amplitude coupling and its relation with overnight improvement of MST performance.Results: Patients did not differ from controls in the timing of SW-spindle coupling. In both groups spindles peaked during the SW upstate. For patients only, the later in the SW upstate that spindles peaked and the more reliable this phase relationship, the greater the overnight MST improvement.Regression models that included both spindle density and SW-spindle coordination predicted overnight improvement significantly better than either parameter alone suggesting that both contribute to memory consolidation.Conclusions: Schizophrenia patients show intact spindle-SW temporal coordination and these timing relationships, together with spindle density, predict sleep-dependent memory consolidation.These relations were seen only in patients suggesting that their memory is more dependent on optimal spindle-SW timing, possibly due to reduced spindle density. Interventions to improve memory may need to both increase spindle density and optimize the coordination of NREM oscillations.

show abstract

“…We report N2 findings based on prior studies showing N2 spindle abnormalities in schizophrenia and correlations of N2 spindle activity with sleep-dependent memory consolidation 4,7,11 .…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Demanuele

Bartsch

Baran

et al. 2016

Sleep

View full text Add to dashboard Cite

show abstract

“…Results also revealed a possible beneficial short-term effect of eszopiclone on working memory. Importantly, memory deficits are related to reduced sleep spindle activity [16,19], and eszopiclone has been shown to increase sleep spindles in a recent double-blind, randomized placebo-controlled trial of 21 people with schizophrenia but without insomnia who were taking second-generation antipsychotic medication [43•]. Although eszopiclone did not improve procedural memory in that sample, it appeared to selectively enhance spindle activity, with sleep spindle number and density predicting procedural memory.…”

Section: Treatment and Managementmentioning

confidence: 99%

“…In schizophrenia, poor sleep quality is associated with diminished quality of life [11,12], greater positive symptoms [13], peripheral immune measure alterations [14], and impaired cognitive functions [15], including impaired sleepdependent memory consolidation [16][17][18][19]. Sleep deprivation in healthy individuals shares many similarities to clinical manifestations observed in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disorders Among People With Schizophrenia: Emerging Research

Klingaman

Palmer-Bacon

Bennett

et al. 2015

Curr Psychiatry Rep

View full text Add to dashboard Cite

Up to 80 % of individuals with schizophrenia spectrum disorders experience sleep disturbances, which impact physical and mental health, as well as quality of life. In this paper, we review and integrate emerging literature, published between 2012 and 2014, regarding approaches to diagnosis and treatment of major sleep disorders for people with schizophrenia spectrum disorders, including insomnia, obstructive sleep apnea (OSA), circadian rhythm dysfunction, and restless legs syndrome (RLS). We advocate for (1) the need to evaluate the utility of nonpharmacological approaches in people with schizophrenia spectrum disorders; (2) documentation of guidelines to assist providers in clinically tailoring such interventions when their clients experience positive, negative, and/or cognitive symptoms; (3) research on the best ways providers can capitalize on clients' self-identified needs and motivation to engage in sleep treatments through shared decision making; and (4) the importance of investigating whether and how mental health and sleep treatment services should be better connected to facilitate access for people with schizophrenia spectrum disorders. Assessment and tailored treatment of sleep disorders within mental health treatment settings has the potential to reduce sleep problems and improve functioning, quality of life, and recovery of this population.

show abstract