Impairment of the Blood-Brain Barrier as an Aetiological Factor in Paranoid Psychosis

Axelsson, Rolf; Mårtensson, Erik; Alling, Christer

doi:10.1192/bjp.141.3.273

Cited by 58 publications

(24 citation statements)

References 11 publications

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“…Several studies (Axelsson et al, 1982; Karanikas, 2011; Muller et al, 1999b; Schwarz et al, 2000) that have reported an impaired blood-brain barrier in SCZ subjects, suggest that psychotic phenotype may be caused by degenerative immune-processes, similarly to Multiple Sclerosis (MS) (Amital and Shoenfeld, 1993; Ruutiainen et al, 1981). …”

Section: Discussionmentioning

confidence: 99%

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Calabrò

Drago

Sidoti

et al. 2015

Psychiatry Research

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A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4,486 Schizophrenic patients and 4,477 controls served as the investigation sample. 3,521 Bipolar patients and 3,195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.

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Section: Discussionmentioning

confidence: 99%

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Calabrò

Drago

Sidoti

et al. 2015

Psychiatry Research

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“…It is clear that the capillary MAO must be involved in the deamination ofdopamine and possibly also other amine neurotransmitters or modulators. An impairment in the permeability of the blood-brain barrier might be implicated in the aetiology of psychiatric illness, such as paranoid psychosis (Axelsson et aL, 1982) and in this context, it is perhaps relevant to note that several age-related changes in the cerebral microvasculature have been described including loss of endothelial cells and a decrease in the number of endothelial cell mitochondria (Burns et al, 1979;Raven, 1978). Because of this further studies on the function of brain capillary MAO seems warranted.…”

Section: Resultsmentioning

confidence: 98%

Monoamine oxidase in young and adult rat brain capillaries

1984

J. Neural Transmission

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Capillaries were isolated from young and adult rat brain and the mitochondrial type A and B monoamine oxidase activities in these endothelial cells were determined. Type A activity was observed to be predominant in both young and adult rats and was increased with maturation while type B activity remained unchanged. The predominance of type A MAO in the rat brain capillaries is consistent with that of the rat aorta and heart tissue.

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“…The protein fractions in serum and cerebrospinal fluid (CSF) were determined as described in aprevious study (AXELSSON et al 1982).…”

Section: Hereditas J J I (1989)mentioning

confidence: 99%

“…The ratings included all 61 CPRS items and the total psychopathology was used in the analyses ("total CPRS score"). Separate analyses were made of the subscores for cerebrolesional symptoms, depressive symptoms, and disorientation (AXELSSON et al 1982). …”

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confidence: 99%

Familial and environmental aetiologic factors in paranoid psychosis quantified by a new statistical method

Axelsson

Odén

2008

Hereditas

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A new mathematical model for quantification of familial factors was used in this study of psychiatric morbidity among the first-degree relatives of 25 patients with paranoid psychosis. The method provides a measure, a familial score of psychiatric morbidity of practical value in correlation analysis since it is applicable at different numbers of relatives per proband, excludes the influence of systematical errors, and allows the inclusion of background factors. A total of 159 first-degree relatives above the age of 15 were traced, 44 (28 %) of whom were found to have a history of psychiatric disorder. The familial score of psychiatric morbidity, which varied between 2.0 and 23.0 in the 25 patients, was not significantly correlated to neurophysiological findings or clinical picture. A highly significant negative correlation between the familial score and parental age suggested that the relative influence of nonfamilial factors on the development of psychiatric disorder may be increased with increasing parental age. R. Anelsson, Deportment of Psychiatry and Neurochemistry, University of Lund, Box 638, S-220 06 LundPathogenetic effects of both familial (e.g., genetic factors) and non-familial factors (e.g., environmentally induced brain damage, viral infection) have long been recognized in a wide range of psychiatric disorders (NIMGAONKAR et al. 1988;MENDLEWICS 1988). The relative influence of these factors have been difficult to evaluate, however, not least because no satisfactory method has been available. In the present study of psychiatric morbidity in the families of 25 patients with paranoid psychosis, the influence of familial and non-familial factors on the clinical characteristics of paranoid psychosis were evaluated by means of a new statistical method. The method made it possible to calculate a familial score of psychiatric morbidity, i.e., a measure of the relative influence of familial and environmental factors associated with psychiatric disorder. Since the method provides a numerical value directly applicable in correlation analysis, it facilitates the analysis of large samples and excludes the influence of systematical errors. Subjects and methods PatientsConsecutively admitted in patients with acute paranoid psychosis and born in Sweden were considered for participation in the study. The following diagnostic groups according to DSM I11 (American Psychiatric Association 1980) were found: atypical psychosis (n=9), acute paranoid disorder (n=7), paranoia (n=4), schizo-affective psychosis (n=2), organic delusional syndrome (n=2) and paranoid schizophrenia (n=l). Those with major affective disorders, dementia concomitant, physical disorders, and substance abuse disorders were excluded. Twenty-five patients, 9 men and 16 women, aged 25-76 years (mean age 57), were admitted in the study. Five of the patients had n o previous admission to psychiatric hospital, 3 had more than 10 previous admissions, and the median number of previous admissions was 4. The duration of psychosis varied between 0-40 years (mea...

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Impairment of the Blood-Brain Barrier as an Aetiological Factor in Paranoid Psychosis

Cited by 58 publications

References 11 publications

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls

Monoamine oxidase in young and adult rat brain capillaries

Familial and environmental aetiologic factors in paranoid psychosis quantified by a new statistical method

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