Impairment of the reproductive potential of male fathead minnows by environmentally relevant exposures to 4-nonylphenolf

Schoenfuss, Heiko L.; Bartell, Steve; Bistodeau, T.B.; Cediel, Roberto A.; Grove, Kent J.; Zintek, Larry; Lee, K.E.; Barber, Larry B.

doi:10.1016/j.aquatox.2007.10.004

Cited by 63 publications

(45 citation statements)

References 31 publications

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“…Sensitivity of RT to estrogenic activity is similar to that reported for fathead minnow (both within 6-10 lg/L of NP) (Schoenfuss et al 2008;Spehar et al 2010;Ward and Boeri 1991). NP has also been shown to cause reproductive behavioral impairment in FHM and increased egg mortality in RT (Schoenfuss et al 2008;Schwaiger et al 2002).…”

Section: Discussionsupporting

confidence: 77%

“…Finally, sample size for some of the treatments were low (n = 3), and therefore there was a greater chance for variability. The rationale for using this mixture was that NP and OP and their ethoxylates have been shown to induce VTG mRNA of juvenile and male animals in a number of fish species, and analytical standards to measure these compounds in environmental media were available (Denny et al 2005;Ishibashi et al 2006;Li et al 2012;Jobling and Sumpter 1993;Schoenfuss et al 2008;Van den Belt et al 2003;Ferguson et al 2003). In contrast, the study by Xie et al (2005) used an unknown mixture of AP and APEs in a commercial product (TPA) that contained a multitude of ethoxylate and alkylphenol isomers, which have different estrogenic potencies as well as targets exclusive of the estrogen receptor (Nimrod and Benson 1996;Laws et al 2000;Yadetie et al 1999).…”

Section: Discussionmentioning

confidence: 99%

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Exploring the Impacts of Two Separate Mixtures of Pesticide and Surfactants on Estrogenic Activity in Male Fathead Minnows and Rainbow Trout

Crago

Tran

Budicin

et al. 2014

Arch Environ Contam Toxicol

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In this study, male fathead minnows (FHM) (Pimephales promelas) and juvenile rainbow trout (RT; Oncorhynchus mykiss) were exposed to two different surfactant mixtures of analytical-grade nonlyphenol, 4-tert octyphenol, octylphenol ethoxylates, nonylphenol ethoxylates, and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). After a 7-days exposure to environmentally relevant concentrations of these compounds, there was no difference in the relative mRNA expression of vitellogenin (VTG) in male juvenile RT exposed to individual compounds or the 2,4-D-surfactant mixture compared with the control. In male FHM, there was a significant increase in VTG mRNA expression in the high individual treatments of 2,4-D and the surfactants but not the 2,4-D-surfactant mixtures compared with the control. These results were compared with another study exposing male FHM to individual and a mixture of alkylphenols and alkylphenol ethoxylates in two different combinations with the herbicide diuron and the insecticide bifenthrin. There were no differences in the relative expression of VTG mRNA amongst individual exposures and the control. Interestingly, when the ethoxylate mixture was combined with diuron, there was a significant decrease in the relative mRNA expression of VTG compared with the control. However, when the ethoxylate mixture was combined with both diuron and bifenthrin, there was a significant increase in the relative mRNA expression of VTG in male compared with all other groups in the multichemical mixture. The results of this study highlight differences between species and measurements of VTG in assessing the risk of mixtures to aquatic organisms.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Exploring the Impacts of Two Separate Mixtures of Pesticide and Surfactants on Estrogenic Activity in Male Fathead Minnows and Rainbow Trout

Crago

Tran

Budicin

et al. 2014

Arch Environ Contam Toxicol

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“…In addition, this concentration range was associated with estrogenic activity such as increased vitellogenin production by male fish and incidences of intersex in both male and female offspring. More recently, concentrations in the range of 0.25 to 15 mg/L were found to alter the reproductive behavior of fathead minnows during spawning, but did not significantly increase vitellogenin at the end of the test [32]. Although these latter studies conclude that endocrine disruption effects from nonylphenol are variable among fish and should not be used alone in making hazard assessments, these results in combination with the present findings and other toxicological observations cited here suggest that nonylphenol has the potential to be toxic to sensitive freshwater organisms at environmental concentrations.…”

Section: Toxicity Testsmentioning

confidence: 97%

Comparative toxicity and bioconcentration of nonylphenol in freshwater organisms

Spehar

Brooke

Markee

et al. 2010

Enviro Toxic and Chemistry

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Degradation of alkylphenol ethoxylates to more persistent alkylphenols such as nonylphenol occurs in wastewater treatment plants where nonylphenol is released to aquatic systems. In this study, acute and chronic tests were conducted to determine the toxicity and bioconcentration of nonylphenol to freshwater organisms for use in deriving national water quality criteria. Acute median effect concentrations (EC50s) based on loss of equilibrium, immobility, and lethality for species representing several taxonomic groups ranged from 21 to 596 microg/L. The EC50s were up to a factor of 2 less than median lethal concentrations (LC50s) and decreased with time over the test periods of 24 to 96 h. In chronic tests, early life stages of rainbow trout were 14 times more sensitive to nonylphenol than in acute tests and approximately 20 times more sensitive than Daphnia magna exposed over their complete life cycle. Comparisons of chronic test endpoints showed that 20% effect concentrations (EC20s), determined by regression testing, and chronic values, determined by hypothesis testing, were similar for both the rainbow trout and Daphnia magna. The lowest mean tissue-effect concentrations of nonylphenol appeared to be greater for the fathead minnow than bluegill, and ranged from approximately 130 to 160 microg/g after 96-h exposure and from approximately 20 to 90 microg/g after 28-d exposure. Mean lipid normalized bioconcentration factors (BCFs) associated with no-effect concentrations were approximately 180 and 50 for the fathead minnow and bluegill, respectively. The present test results suggest that long-term exposures to nonylphenol at concentrations found in some surface waters could adversely impact sensitive components of freshwater communities.

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“…Treatment-specific chemicals were added to the conditioned well water before daily water exchange (50% daily static renewal). Ethanol solvent concentrations in the treatments did not exceed 8.5 ll ethanol/l well water, which was lower than solvent concentrations used in previous experiments (Barber et al 2007;Schoenfuss et al 2008) and lower than reported no-effect concentrations for ethanol in fathead minnows (Yokoto et al 2001). After the 12-day exposures, predator avoidance response was assessed by the C-start performance assay as published previously (McGee et al 2009;Painter et al 2009).…”

Section: Larval Exposure Experimentsmentioning

confidence: 98%

Effects of Triclosan and Triclocarban, Two Ubiquitous Environmental Contaminants, on Anatomy, Physiology, and Behavior of the Fathead Minnow (Pimephales promelas)

Schultz

Bartell

Schoenfuss

2012

Arch Environ Contam Toxicol

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Triclosan (TCS) and triclocarban (TCC) are two common antimicrobial agents found in many personal care products and subsequently are detected ubiquitously in wastewater effluent and receiving waters. Both compounds are of recent regulatory interest due to their omnipresence in the environment, including in humans. Although TCS and TCC have been suggested to be endocrine active, little information exists about their effects on organismal end points in development (growth, escape performance), anatomy (morphological indices, histology), physiology (vitellogenin), and behavior of exposed aquatic organisms. In this study, newly hatched fathead minnows were exposed for 12 days, and mature male and female fathead minnows (Pimephales promelas) were exposed for 21 days to environmentally realistic concentrations (nanograms per liter) of these two compounds singularly and in mixtures. At the end of the exposure, larvae were assessed for growth and predator-avoidance performance, and a subset of mature fish was assessed for plasma vitellogenin induction, expression of secondary sexual characteristics, relative size of liver and gonads, and histopathological changes to both organs. The remaining exposed mature fish were placed in breeding pairs of one male and one female minnow from the same treatment to assess their ability to defend a nest site and reproduce. Exposure to either antimicrobial compound, alone or as a mixture, caused no changes to larval fish, gonad size, or vitellogenin concentrations in mature fathead minnows. In contrast, decreased aggression was seen in adult male fathead minnows exposed to TCC (1.6 μg/l) or a mixture (560 ng/l TCS + 179 ng/l TCC and 1.6 μg/l TCS + 450 ng/l TCC). Decreased aggression would likely decrease their ability to defend and hold a nest site needed for spawning and reproduction. Substantial variability was found in the severity of observed effects within treatments, suggesting that environmentally realistic concentrations of these compounds may only affect particularly sensitive individuals.

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Impairment of the reproductive potential of male fathead minnows by environmentally relevant exposures to 4-nonylphenolf

Cited by 63 publications

References 31 publications

Exploring the Impacts of Two Separate Mixtures of Pesticide and Surfactants on Estrogenic Activity in Male Fathead Minnows and Rainbow Trout

Exploring the Impacts of Two Separate Mixtures of Pesticide and Surfactants on Estrogenic Activity in Male Fathead Minnows and Rainbow Trout

Comparative toxicity and bioconcentration of nonylphenol in freshwater organisms

Effects of Triclosan and Triclocarban, Two Ubiquitous Environmental Contaminants, on Anatomy, Physiology, and Behavior of the Fathead Minnow (Pimephales promelas)

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