Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: novel insights from quails

Suljević, Damir; Corbic, Anida; Islamagić, Erna; Fočak, Muhamed; Filipić, Filip; Alijagić, Andi

doi:10.1016/j.etap.2019.103250

Cited by 24 publications

(4 citation statements)

References 34 publications

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“…The current study revealed that the Cd-intoxicated group showed a notable increase in the heterophil percentage and H/L ratio with a reduction of the lymphocyte percentage which may be due to the glucocorticoid influence. Similar findings were reported by [107] who concluded that Cd has marked immuno-toxic effects on the hematopoietic stem cells via increasing the myeloid progenitors and decreasing the lymphoid progenitors in exposed quails. Furthermore [108], documented that broilers experienced thermal stressreleased excessive glucocorticoids resulting in severe leukopenia and lymphopenia with marked shift in the H/L ratio which regarded as an index of stress in broilers.…”

Section: Discussionsupporting

confidence: 89%

Rutin Nanoparticles Alleviate Cadmium-Induced Oxidative and Immune Damage in Broilers’ Bursa of Fabricius via Modulating Hsp70/TLR4/NF-κB Signaling Pathway

Abomosallam,

Hendam,

Shouman

et al. 2024

Biol Trace Elem Res

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Cadmium (Cd) is a serious environmental pollutant affecting various tissues/organs in broilers and compromising their immunological function and productivity. Therefore, the current study aimed to investigate Cd-induced immunotoxicity and potential immunoprotective effect of rutin nanoparticles (RNPs) in the bursal tissue of broilers. A total number of 150 chicks from the Hubbard breed were randomly divided into 5 groups. Group I was fed on standard basal diet (SD) with normal drinking water (DW), Group II received SD containing RNPs (50 mg/kg feed) with DW, Group III fed on SD and DW containing Cd (150 mg/L), Group IV co-treated with rutin-enforced SD (50 mg/kg diet) and DW containing Cd (150 mg/L), and finally, Group V co-supplemented with RNP-enhanced SD (50 mg/kg diet) DW containing Cd (150 mg/L). Productive performance, economic efficiency, oxidative biomarkers, histopathological changes, and the expression level of TLR-4, HSP-70, caspase 3, NF-κB, Bcl-2, and Bax were assessed in the BF tissue. Cd led to severe production and economic losses in exposed birds with a marked surge of oxidative biomarkers, pro-inflammatory cytokines, and histopathological changes in the bursal tissue which could be explained through upregulation of the Hsp70/TLR4/NF-κB molecular pathway in the BF tissue. Meanwhile, RNPs could alleviate most of these changes and prevail optimistic immunomodulatory properties which subsequently could enhance broilers’ productivity when incorporated in their diets. Graphical Abstract

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Section: Discussionsupporting

confidence: 89%

Rutin Nanoparticles Alleviate Cadmium-Induced Oxidative and Immune Damage in Broilers’ Bursa of Fabricius via Modulating Hsp70/TLR4/NF-κB Signaling Pathway

Abomosallam,

Hendam,

Shouman

et al. 2024

Biol Trace Elem Res

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“…Mengjiao Bi et al (Bi et al 2019) reported the molecular mechanisms of Pb-induced changes of selenium status in mice livers through interacting with selenoprotein P. The research results of Debashis Reja et al (Reja et al 2020) showed that blood Pb level was associated with advanced liver brosis in patients with non-alcoholic fatty liver disease. Damir Suljevic et al (Suljevic et al 2019) thought that chronic Cd exposure in vivo could cause damage to bone marrow hematopoietic cells, followed by severe red blood cell damage and liver necrosis. Eunjung Park et al (Park et al 2021) conducted a study on the relationship between environmental Cd exposure and the risk of suspected nonalcoholic fatty liver disease.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lead and Cadmium Combined Heavy Metals on Liver Function and Lipid Metabolism in Mice

Chen

Zhu

Zhou

2022

Biol Trace Elem Res

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Although a large number of studies have been conducted on individual lead (Pb) or cadmium (Cd) exposures, the toxicity of combined Pb and Cd exposures is relatively limited. The present study aims to investigate toxicity of Pb-Cd combined heavy metals and its mechanism. A heavy metal exposure model was established by subcutaneous intragastric administration of Pb-Cd (50:1) for 35 days in mice. The body weight, diet, hair color, mental state, liver index, hematological index, biochemical indicators and pathological section were used to comprehensively evaluate the toxicity reaction. Then, classical oxidative stress indexes and lipidomics techniques had been used to explore the potential mechanism. The results showed that Pb-Cd could cause inappetite, poor spirit, signi cantly reduced activity, slow weight gain and dark hair color in mice. Pb-Cd could also cause liver enlargement, AST and ALT enzyme activities signi cantly increased, and pathological changes of liver. Prolonged exposure to c could also cause PCT, WBC, PLT and MON signi cantly increased, and RBC, HGB, HCT and LYM decreased. Pb-Cd can increase the oxidative stress by increasing the activity of SOD and LDH and the content of MDA. Pb-Cd also could cause lipid metabolism disorders by regulating linoleic acid metabolism, sphingolipid metabolism and glycerolipid metabolism.

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“…The slides were fixed in methanol (p.a. 99.9%; Semikem) for 5 min before being stained with Giemsa for 20 min (1:10 dilution with water) according to Mackei et al 32 Using an optical microscope (Olympus BX41) and a ×100 magnification, the slides were utilized to examine liver cells, as indicated by Suljevic et al 33 …”

Section: Methodsmentioning

confidence: 99%

Protective role of the dandelion extract against the blood–liver axis, cell membranes, and anemia disorder in sodium benzoate‐exposed rats

Suljević

Mitrašinović-Brulić

Dervišević

et al. 2022

Cell Biochemistry & Function

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Sodium benzoate (SB) as an additive in various food products prevents the growth of microbes. Although SB is considered safe, many studies have reported adverse effects. The aim of this study was to investigate the effect of dandelion extract on cell damage and hematological and biochemical disorders induced by SB in male albino rats. Different doses of SB (200 and 600 mg/kg) and ethanolic dandelion root extract (D) (40 mg/kg) were used in a 2-week treatment of rats. Rat mortality and a higher frequency of behavioral alterations such as apathy, anxiety, and aggression have been reported at a higher dose of SB. Changes in urine pH, proteinuria, nitrituria, and bilirubinemia caused by SB were regulated by adding dandelion extract. Analysis of specific serum and urine parameters, as well as microscopic analysis of hepatocytes, showed liver and kidney failure. Anemia associated with hemolytic disorder due to erythrocyte impaired the presence of acanthocytes, and decreased values of erythrocyte blood count, hemoglobin concentration, average red blood cell size, hemoglobin amount per red blood cell, and mean corpuscular hemoglobin concentration were caused by SB treatment. As a dietary supplement, dandelion extract can be useful in the prevention of SB-induced liver and kidney injury, and also a remedy against induced anemia, neutropenia, thrombocytopenia, hyperproteinemia, hyperglycemia, and reduction of inflammatory responses.

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Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: novel insights from quails

Cited by 24 publications

References 34 publications

Rutin Nanoparticles Alleviate Cadmium-Induced Oxidative and Immune Damage in Broilers’ Bursa of Fabricius via Modulating Hsp70/TLR4/NF-κB Signaling Pathway

Rutin Nanoparticles Alleviate Cadmium-Induced Oxidative and Immune Damage in Broilers’ Bursa of Fabricius via Modulating Hsp70/TLR4/NF-κB Signaling Pathway

Effects of Lead and Cadmium Combined Heavy Metals on Liver Function and Lipid Metabolism in Mice

Protective role of the dandelion extract against the blood–liver axis, cell membranes, and anemia disorder in sodium benzoate‐exposed rats

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