2023
DOI: 10.1093/ehjacc/zuad036.098
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Impella for the management of ventricular septal defect complicating acute myocardial infarction: insights from an European multicenter retrospective analysis. The VSD-IMPELLA study

Abstract: Funding Acknowledgements Type of funding sources: None. Backgroud Ventricular septal defect (VSD), is a rare but fatal complication of myocardial infarction (MI) associated with high early mortality. Temporary mechanical circulatory support (t-MCS) of any type can be used to stabilize the patient as a bridge to surgical or percutaneous closure, or to heart transplantation or long-term ventricular assist device, but with a low… Show more

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“…It was with great interest that we read the article published by Delmas et al ., 1 which is a European multicenter survey on the use of Impella devices as a bridge to surgical repair, bridge to percutaneous closure, or bridge to recovery/no intervention. This study included 28 patients with postmyocardial infarction ventricular septal ruptures (post-MI VSRs), who were all in cardiogenic shock upon presentation.…”
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confidence: 99%
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“…It was with great interest that we read the article published by Delmas et al ., 1 which is a European multicenter survey on the use of Impella devices as a bridge to surgical repair, bridge to percutaneous closure, or bridge to recovery/no intervention. This study included 28 patients with postmyocardial infarction ventricular septal ruptures (post-MI VSRs), who were all in cardiogenic shock upon presentation.…”
mentioning
confidence: 99%
“…Veno-arterial (VA) ECMO can increase left ventricular (LV) afterload, worsen left-to-right shunting, and is usually avoided as a sole means of MCS in post-MI VSRs. Nonetheless, few case series, including this study by Delmas et al ., 1 have demonstrated successful LV unloading and hemodynamic support with Impella, for patients with post-MI VSRs, before surgical repair. 7,8 The use of Impella devices for VSRs is relatively contraindicated, as it can theoretically reverse the shunt causing hypoxia and can also dislodge the fragile infarcted septal tissue causing distal embolization, including stroke.…”
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confidence: 99%
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