Imperatorin exerts antiallergic effects in Th2-mediated allergic asthma via induction of IL-10-producing regulatory T cells by modulating the function of dendritic cells

Lin, Chu Lun; Hsiao, George; Wang, Ching Chiung; Lee, Yueh Lun

doi:10.1016/j.phrs.2016.04.030

Cited by 37 publications

(18 citation statements)

References 52 publications

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“…Previous studies have noted that IL-10-producing Treg cells play a key role in immune tolerance, preventing uncontrolled inflammation and immunopathology. [34][35][36][37] These Treg cells can inhibit effector T-cell proliferation and cytokine production, reduce IgE production, suppress airway eosinophilia and downregulate the release of proinflammatory cytokines from mast cells by mechanisms involving IL-10 in allergic diseases. [38][39][40][41] Collectively, our findings suggest that osthole treatment dampened effector Th2 cell responses to limit allergen-induced immunopathology, at least in part by augmenting the numbers of IL-10 + Foxp3 + Treg cells.…”

Section: Discussionmentioning

confidence: 99%

Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function

et al. 2017

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Osthole, an active component of Chinese herbal medicines, reportedly possesses various pharmacological properties and has potential therapeutic applications. This study explored the anti-allergic effects of osthole in asthmatic mice and investigated the immunomodulatory actions of osthole on dendritic cells (DCs) and T cells. Herein, we show that oral administration of osthole to BALB/c mice after ovalbumin (OVA) sensitization ameliorated all of the cardinal features of T helper 2 (Th2)-mediated allergic asthma; namely, the production of OVA-specific immunoglobulin E, airway hyperresponsiveness, airway inflammation and the production of Th2-type cytokines including interleukin (IL)-4, IL-5 and IL-13. Surprisingly, IL-10 production was not inhibited and was even enhanced by osthole treatment. We observed a significant increase in the percentages of IL-10-producing DCs and forkhead box P3-positive regulatory T (Treg) cells in osthole-treated asthmatic mice. Additionally, in vitro analyses revealed that osthole-treated bone-marrow-derived DCs had a partial maturation phenotype, secreting large amounts of IL-10 and low levels of proinflammatory cytokines, such as IL-12, IL-6 and tumor necrosis factor-α, and displaying reduced levels of MHC class II surface molecules. These DCs displayed immunosuppressive capacity by directly inhibiting effector T-cell responses or inducing Treg cells. In addition, osthole directly inhibited the activated CD4 T-cell proliferation and Th1/Th2-type cytokine production in this system. Collectively, these results suggest that DCs and T cells are potential target cells responsible for the action of osthole against allergic asthma.Cellular &Molecular Immunology advance online publication, 7 August 2017; doi:10.1038/cmi.2017.71.

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Section: Discussionmentioning

confidence: 99%

Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function

et al. 2017

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“…In asthmatic mice, IMP, in a dose-dependent manner, reduced IgE levels, airway hyperresponsiveness, and Th2 cytokines and increased IL-10-producing T cells. In LPS-stimulated DCs, IMP increased IL-10 and suppressed the release of proinflammatory cytokines [72]. Li et al have reported that IMP effectively diminished COX-2, IL-6, TNF-α, and iNOS expression via downregulation of NF-κB and JAK/STAT signaling in alveolar macrophages [74].…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

“…The pharmacological properties of IMP make it a promising candidate for drug development. It has been documented to possess antioxidant [66,67], anti-inflammatory [68,69], anticancer [68,70], antibacterial [71], and antiallergic activities [72]. Singh et al reported that IMP treatment significantly reduced the 2…”

Section: Imperatorin (Imp)mentioning

confidence: 99%

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Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Hassanein

Sayed

Hussein

et al. 2020

Oxidative Medicine and Cellular Longevity

164

106

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The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-κB. Therefore, pharmacological activation of Nrf2 is a promising therapeutic strategy for the treatment/prevention of several diseases that are underlined by both oxidative stress and inflammation. Coumarins are natural products with promising pharmacological activities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory efficacies. Coumarins are found in many plants, fungi, and bacteria and have been widely used as complementary and alternative medicines. Some coumarins have shown an ability to activate Nrf2 signaling in different cells and animal models. The present review compiles the research findings of seventeen coumarin derivatives of plant origin (imperatorin, visnagin, urolithin B, urolithin A, scopoletin, esculin, esculetin, umbelliferone, fraxetin, fraxin, daphnetin, anomalin, wedelolactone, glycycoumarin, osthole, hydrangenol, and isoimperatorin) as antioxidant and anti-inflammatory agents, emphasizing the role of Nrf2 activation in their pharmacological activities. Additionally, molecular docking simulations were utilized to investigate the potential binding mode of these coumarins with Keap1 as a strategy to disrupt Keap1/Nrf2 protein-protein interaction and activate Nrf2 signaling.

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“…Furthermore, TSLP upregulates the expression of surface co-stimulatory molecules, including CD40, CD80 and CD86 on DCs. Under the influence of secreted cytokines and membrane-expressed molecules including OX40 L, Jagged1, IL-6 and leukotrienes C4, activated inflammatory DCs interact with naive CD4 + T cells and induce the differentiation of Th2, Th17 and follicular helper T cells (45,46). CCR3 and CCR4 surface receptors of Th2 cells directly bind to chemokines secreted by epithelial cells.…”

Section: Functional Properties Of Chemokines and Associations Betweenmentioning

confidence: 99%

Role of epithelial chemokines in the pathogenesis of airway inflammation in asthma (Review)

et al. 2018

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As the first barrier to the outside environment, airway epithelial cells serve a central role in the initiation and development of airway inflammation. Chemokines are the most direct and immediate cell factors for the recruitment and migration of inflammatory cells. The present review focused on the role of epithelial chemokines in the pathogenesis of airway inflammation in asthma. In addition to traditional CC family chemokines and CXC family chemokines, airway epithelial cells also express other chemokines, including thymic stromal lymphopoietin and interleukin‑33. By expressing and secreting chemokines, airway epithelial cells serve a key role in orchestrating airway inflammation in asthma.

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Imperatorin exerts antiallergic effects in Th2-mediated allergic asthma via induction of IL-10-producing regulatory T cells by modulating the function of dendritic cells

Cited by 37 publications

References 52 publications

Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function

Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Role of epithelial chemokines in the pathogenesis of airway inflammation in asthma (Review)

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