Implanon: A Review of the Literature With Recommendations for Clinical Management

Adams, Kate; Beal, Margaret W.

doi:10.1016/j.jmwh.2008.09.004

Cited by 29 publications

(24 citation statements)

References 35 publications

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“…Otros regí-menes descritos para tratar el sangrado prolongado es el uso de mifepristona y tetraciclina, sin embargo estos no se utilizan en nuestro medio (14). Las reacciones adversas más comunes al IASE son cefaleas, acné, mastalgia, dismenorrea y aumento de peso (8,15).…”

Section: Discussionunclassified

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Patrón de sangrado uterino en adolescentes usuarias de implante anticonceptivo subdérmico de etonogestrel

Molina

Montero

et al. 2016

Rev. chil. obstet. ginecol.

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Section: Discussionunclassified

“…Al igual que en otros estudios, se trataron los casos de sangrado prolongado a través consejería y la prescripción de píldoras anticonceptivas combinadas (desogestrel o levonorgestrel) y/o antiinflamatorios no esteroidales (13,15,24). Destacamos la consejería realizada, para la promoción de la tolerancia a los diferentes patrones de sangrados.…”

Section: Discussionunclassified

Patrón de sangrado uterino en adolescentes usuarias de implante anticonceptivo subdérmico de etonogestrel

Molina

Montero

et al. 2016

Rev. chil. obstet. ginecol.

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“…The reservoir-type systems are commonly used in subcutaneous contraceptive delivery systems. As an example, a subcutaneous rod-shaped device of ethylene vinyl acetate copolymer containing etonogestrel has been designed for hormone release over three years, the implant being 4 cm long and 2 mm in diameter (Adams and Beal 2009).…”

Section: Introductionmentioning

confidence: 99%

Development of functionally-graded reservoir of PCL/PG by selective laser sintering for drug delivery devices

Salmoria

Klauss

Zepon

et al. 2012

Virtual and Physical Prototyping

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Drug delivery devices are systems employed to conduct a drug to a specific site of the body, where it should be released and absorbed. Reservoir-type systems are devices in which the drug is contained within a nucleus isolated from the outside environment by a thin polymeric layer, which regulates a diffusion process driven by a functional concentration gradient. In this study two reservoir-type drug delivery devices based on polycaprolactone (PCL) were developed for the release of progesterone (PG) using the Selective Laser Sintering (SLS) technique, in order to investigate the influence of the concentration gradient promoted during manufacturing on the drug delivery profile. Two types of controlled-drug-release devices were fabricated; the first containing only the polycaprolactone polymer in the reservoir wall (system R) and the second containing PLC and 15% of progesterone in the wall (system R*). The cores of both reservoirs were filled with 40 mg of progesterone. A study on the degradation was conducted to assess the release process of the two systems. The drug delivery results showed that for both reservoirs the amount of drug released was linear over time, featuring zero-order release kinetics. The higher mass loss with the incorporation of the drug into the wall of the reservoir was associated with faster release of the drug to the medium. The feasibility of building threedimensional parts using the SLS technique allowed the construction of reservoir-type devices based on a functional gradient for the controlled-release of the drug.

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“…Within 1 -2 weeks of removal of the Implanon ™ , fertility is reversed (6,8) . There are some other key clinical features of Implanon ™ that a clinician needs to be aware of and are listed below (4,7,9) .…”

Section: Introductionmentioning

confidence: 99%

Menstrual bleeding patterns in adolescents using etonogestrel (ENG) implant

Deokar

Jackson

Omar

2011

International Journal of Adolescent Medicine and Health

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Background: Etonogestrel (ENG) implant is an effective method of contraception. The implant is designed to provide contraceptive effi cacy for 3 years with a relatively quick return of fertility upon its removal. Menstrual irregularities are not uncommon on long-acting progestins and can often be the factor for discontinuation or removal. A retrospective chart analysis was done on 58 patients who chose to be on the ENG implant. Age ranged from 12 to 24 years. The cycle ranged from 1 to 17 months. The mean length of use of the implant was 10.9 months. Over the 20-month period, 13 ENG implants were removed because of menstrual bleeding problems. Method: We conducted a chart review of the adolescent patients who received the ENG implant in our adolescent clinic. An analysis was done based on symptoms experienced by patients who were on the ENG implant and their management, which in some cases resulted in its removal. Setting : The data is presented on adolescent and young adult patients who receive their reproductive care in the Adolescent Medicine Clinic at the University of Kentucky, Lexington, KY, USA. Conclusions : ENG implant when used correctly and as indicated is extremely effective in providing contraception for up to 3 years. However, menstrual irregularities can be very troublesome and often a reason for its removal. In our experience, 22.4 % (13 out of the 58 subjects) had menstrual problems post-insertion that led to its removal. It is crucial for a clinician to inform and be informed about such side effects.

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Implanon: A Review of the Literature With Recommendations for Clinical Management

Cited by 29 publications

References 35 publications

Patrón de sangrado uterino en adolescentes usuarias de implante anticonceptivo subdérmico de etonogestrel

Patrón de sangrado uterino en adolescentes usuarias de implante anticonceptivo subdérmico de etonogestrel

Development of functionally-graded reservoir of PCL/PG by selective laser sintering for drug delivery devices

Menstrual bleeding patterns in adolescents using etonogestrel (ENG) implant

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