Background. Implanon is a long-acting contraceptive method that is extremely effective in preventing pregnancy with a clinical failure rate of less than 1%. Despite these, the rate of Implanon discontinuation is a common problem in various societies and exposes women to unwanted conception and its consequences. Objective. The current study sought to find and consolidate relevant literature on Implanon discontinuation and associated factors in Ethiopia. Methods. Medline, PubMed, Cochrane Library, EMBASE, and Google Scholar databases were systematically searched for studies published in English before December 2021. The included studies were critically appraised using the JBI instrument for observational studies. STATA version 16 was used for analysis. The presence of statistical heterogeneity was checked using Cochran’s
Q
test, and its level was quantified using
I
2
statistics. A pooled estimate of the proportion of outcome variables was calculated. To measure the effect size, pooled odds ratios with 95% CI were computed. Results. The pooled prevalence of Implanon discontinuation in Ethiopia was 32.89%, 95% CI: 24.11%, 41.66%. Experiencing side effects (
OR
=
2.52
, 95% CI 1.75, 3.65), having no children (
OR
=
1.69
, 95% CI 1.15, 2.47), not having received preinsertion counselling (
OR
=
1.65
, 95% CI 1.36, 2.00), having no postinsertion appointment (
OR
=
2.97
, 95% CI 2.10, 4.21), and not satisfied with the service (
OR
=
2.72
, 95% CI 2.47, 5.59) were significantly associated with Implanon discontinuation. Conclusion. The pooled prevalence of Implanon discontinuation in Ethiopia was high. Experiencing side effects, having no child, not receiving preinsertion counselling, having no follow-up appointment, and not being satisfied with the service were significantly associated with Implanon discontinuation. Therefore, healthcare providers should offer preinsertion counselling in accordance with national family planning guidelines, emphasizing the method’s advantages and side effects.