Implant Degradation and Poor Healing After Endovascular Repair of Abdominal Aortic Aneurysms: An Analysis of Explanted Stent-Grafts

Major, Annie; Guidoin, Robert; Soulez, Gilles; Gaboury, Louis; Cloutier, Guy; Sapoval, Marc; Douville, Yvan; Dionne, Guy; Geelkerken, Robert H.; Petrasek, Paul; Lerouge, Sophie

doi:10.1583/06-1812mr.1

Cited by 49 publications

(48 citation statements)

References 35 publications

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“…Poor healing is observed around stent grafts (SG) used for the endovascular treatment of abdominal aortic aneurysms (AAA) [1], with a lack of organized tissue formation in the cavity and absence of incorporation of the polymer graft into the surrounding wall of the blood vessel [1,2]. This can be related to three main factors: (i) the pro-apoptotic environment of a diseased aneurysmal vessel, characterized by changes in extracellular matrix composition, presence of inflammatory cells, vascular cell depletion [3,4]; (ii) the lack of oxygen and nutrients after SG insertion; and (iii) the nature of the materials used for SG cover, namely polyethylene terephtalate (PET) or poly(tetrafluoroethylene) (PTFE).…”

Section: Introductionmentioning

confidence: 99%

In Vitro and Pilot In Vivo Evaluation of a Bioactive Coating for Stent Grafts Based on Chondroitin Sulfate and Epidermal Growth Factor

Lequoy¹,

Savoji²,

Saoudi³

et al. 2016

Journal of Vascular and Interventional Radiology

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2 AbstractPurpose: To evaluate the potential of a bioactive coating based on chondroitin sulfate (CS) and tethered epidermal growth factor (EGF) for the improvement of healing around stent-grafts (SG). Methods:The impact of the bioactive coating on cell survival was tested in vitro on human vascular cells using polyethylene terephtalate films (PET) as a substrate. After being transferred onto a more "realistic" material (expanded poly(tetrafluoroethylene), ePTFE), the durability and mechanical behavior of the coating in addition to cell survival were studied. Preliminary in vivo testing was performed in a canine iliac aneurysm model reproducing type I endoleaks (3 animals with 1 control and 1 bioactive SG for each). Results:The CS and EGF coatings significantly increased survival of human smooth muscle cells and fibroblasts, compared with bare PET or ePTFE (P<.05). The coating also displayed good durability over 30 days according to ELISA and cell-survival tests.The coating did not affect the mechanical properties of ePTFE and was successfully transferred onto commercial SG for in vivo testing. According to CT-scan and macroscopic examinations, no difference was observed in endoleak persistence at three months, but the bioactive coating deposited on the abluminal surface of the SG (exposed to the vessel wall) increased the percentage of healed tissue in the aneurysm. Moreover, no adverse effect such as neointima formation or thrombosis was observed. Conclusion:The bioactive coating promoted in vitro cell survival, displayed good durability and was successfully transferred onto a commercial SG. Preliminary in vivo results suggest improved healing around bioactive SG.3

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Section: Introductionmentioning

confidence: 99%

In Vitro and Pilot In Vivo Evaluation of a Bioactive Coating for Stent Grafts Based on Chondroitin Sulfate and Epidermal Growth Factor

Lequoy¹,

Savoji²,

Saoudi³

et al. 2016

Journal of Vascular and Interventional Radiology

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“…Mounting evidence suggests that complications are related to deficient healing around SGs. Even several years after implantation, SGs were found to be surrounded by an amorphous, unorganised thrombus composed mainly of a fibrin matrix and phantoms of red blood cells, and characterised by a strong deficit in vascular smooth muscle cells (VSMC), myofibroblasts and collagenous extracellular matrix (ECM) [10][11][12]. The lack of vascular cell ingrowth into the graft material limits its fixation to the vessel wall and prevents a good seal at the neck of the aneurysm.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen-rich coatings for promoting healing around stent-grafts after endovascular aneurysm repair

et al. 2007

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“…As stent material corrosion is already reported, the wear withstanding properties of endomaterials require specific testing [95–97]. Six million cycles of carbon-coated femoral heads do not seem enough to wear the carbon material as graphene and its derivatives are the second strongest material [98].…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Graphene in Developing the Next Generation of Endomaterials

Patelis

Moris

Matheiken

et al. 2016

BioMed Research International

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Graphene is the first 2-dimensional material and possesses a plethora of original properties. Graphene and its derivatives have exhibited a great potential in a number of fields, both medical and nonmedical. The aim of this review is to set the theoretical basis for further research in developing graphene-based endovascular materials. An extensive search was performed in medical and bioengineering literature. Published data on other carbon materials, as well as limited data from medical use of graphene, are promising. Graphene is a promising future material for developing novel endovascular materials. Certain issues as biocompatibility, biotoxicity, and biostability should be explored further.

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Implant Degradation and Poor Healing After Endovascular Repair of Abdominal Aortic Aneurysms: An Analysis of Explanted Stent-Grafts

Cited by 49 publications

References 35 publications

In Vitro and Pilot In Vivo Evaluation of a Bioactive Coating for Stent Grafts Based on Chondroitin Sulfate and Epidermal Growth Factor

In Vitro and Pilot In Vivo Evaluation of a Bioactive Coating for Stent Grafts Based on Chondroitin Sulfate and Epidermal Growth Factor

Nitrogen-rich coatings for promoting healing around stent-grafts after endovascular aneurysm repair

The Potential Role of Graphene in Developing the Next Generation of Endomaterials

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