Implant fixation by bone ingrowth

Kienapfel, H.; Sprey, C.; Wilke, Axel; Griss, P.

doi:10.1016/s0883-5403(99)90063-3

Cited by 374 publications

(222 citation statements)

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“…15 However, long-term stability and survival of cementless implants depends on osseointegration. 16 One way to enhance osseointegration could be through preservation of the autograft created in situ by the bone compaction technique. 14 We have previously, in a 4-week study, shown that local application of the bisphosphonate alendronate can preserve this autograft.…”

Section: Introductionmentioning

confidence: 99%

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Jakobsen

Kold

Bechtold

et al. 2006

Journal Orthopaedic Research

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Bone compaction has been shown to increase initial implant fixation. Furthermore, bone compaction creates a peri-implant zone of autograft that exerts osteoconductive properties. We have previously shown that locally applied bisphosphonate (alendronate) at 4-week observation can preserve the autograft generated by bone compaction. We now investigate whether the increased amount of autograft, seen at 4 weeks, can increase implant osseointegration and biomechanical fixation. Porous-coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs. On the right side, local bisphosphonate was injected into the bone cavity prior to bone compaction immediately prior to implant insertion. On the left side, saline was used as control. Observation period was 12 weeks. Locally applied bisphosphonate significantly increased biomechanical implant fixation (approximately twofold), bone-to-implant contact (1.2-fold), and peri-implant bone volume fraction (2.3-fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown. ß

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Section: Introductionmentioning

confidence: 99%

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Jakobsen

Kold

Bechtold

et al. 2006

Journal Orthopaedic Research

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“…These macropores are well suited for bone ingrowth, where several scholars reported that the optimum pore size range is 100-400 micron, while some extend this range up to 500 microns [21]. Furthermore, the presence of micropores can be of potential benefit as it has been found that micropores as small as 50 µm can promote blood vessel growth within the implant [5,6]. …”

Section: Results and Discussion Figure 2 Transverse Cross-section Bementioning

confidence: 99%

“…The presence of pores in the structure of the foams can solve this and also promote bone ingrowth as well as cell attachment and consequently, improve the osseo-integration of these implants [3]. Although the optimum size of pores for bone ingrowth is still under debate, several studies reported that the ideal size range is about 100-400 µm [4][5][6]. Almost all production processes for titanium foams use metal powder.…”

Section: Introductionmentioning

confidence: 99%

Open pore titanium foams via metal injection molding of metal powder with a space holder

Shbeh

Goodall

2016

Metal Powder Report

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“…Coupled with this, there is an increasing need for the treatment of younger and more active patients, which places greater demands on the implants used. Long‐term implant success in these younger and more active patients depends greatly on effective biological fixation by bone in growth (Kienapfel et al, 1999; McLaughlin and Lee, 2011). In order to achieve this, surgeons use cementless press‐fit prostheses with surface modifications to promote bone in‐growth as well as initial primary fixation by mechanical interlocking (Sammons, 2011).…”

Section: Introductionmentioning

confidence: 99%

Combining 3D human in vitro methods for a 3Rs evaluation of novel titanium surfaces in orthopaedic applications

Stevenson

Rehman

Draper

et al. 2016

Biotech & Bioengineering

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In this study, we report on a group of complementary human osteoblast in vitro test methods for the preclinical evaluation of 3D porous titanium surfaces. The surfaces were prepared by additive manufacturing (electron beam melting [EBM]) and plasma spraying, allowing the creation of complex lattice surface geometries. Physical properties of the surfaces were characterized by SEM and profilometry and 3D in vitro cell culture using human osteoblasts. Primary human osteoblast cells were found to elicit greater differences between titanium sample surfaces than an MG63 osteoblast‐like cell line, particularly in terms of cell survival. Surface morphology was associated with higher osteoblast metabolic activity and mineralization on rougher titanium plasma spray coated surfaces than smoother surfaces. Differences in osteoblast survival and metabolic activity on titanium lattice structures were also found, despite analogous surface morphology at the cellular level. 3D confocal microscopy identified osteoblast organization within complex titanium surface geometries, adhesion, spreading, and alignment to the biomaterial strut geometries. Mineralized nodule formation throughout the lattice structures was also observed, and indicative of early markers of bone in‐growth on such materials. Testing methods such as those presented are not traditionally considered by medical device manufacturers, but we suggest have value as an increasingly vital tool in efficiently translating pre‐clinical studies, especially in balance with current regulatory practice, commercial demands, the 3Rs, and the relative merits of in vitro and in vivo studies. Biotechnol. Bioeng. 2016;113: 1586–1599. © 2015 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.

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Implant fixation by bone ingrowth

Cited by 374 publications

References 100 publications

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Open pore titanium foams via metal injection molding of metal powder with a space holder

Combining 3D human in vitro methods for a 3Rs evaluation of novel titanium surfaces in orthopaedic applications

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