Dental implants are designed to ensure natural tooth replacement based on improved design, simplified placement, and long-term survival. This study aimed to compare one-piece implant (OPI) and two-piece implant (TPI) to determine the success rate over the TPI. This study conducted on 15 patients selected with the age range of 20–60 years to place OPI and TPI. The surgical consent form duly signed by the patients was procured. The implants used were of Adin Implant System, and a follow-up examination was done at 3, 6, and 9 months after implant loading and various clinical and radiographic parameters were noted for both OPI and TPI. The clinical parameters measured were Silness, and Loe gingival index and probing depth and the radiographic parameters included crestal marginal bone loss. Independent Sample t-test and ANOVA were used for statistical analysis. The statistical analysis showed no significant difference between the OPI and TPI based on the gingival index, probing depth, and crestal bone loss. On the contrary, there was a statistical significance in comparing the same parameters during the follow-up period of 3, 6, and 9 months. Over a protracted period, OPIs are better than TPIs by the design and placement procedure. Further research with a higher sample size shall possibly establish esoteric results on a large scale.