Implant loss and crestal bone loss in immediate versus delayed load in edentulous mandibles: A systematic review and meta-analysis

Pardal-Peláez, Beatriz; Flores-Fraile, Javier; Pardal-Refoyo, José Luis; Montero, Javier

doi:10.1016/j.prosdent.2020.01.032

Cited by 22 publications

(16 citation statements)

References 16 publications

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“…Still, due to the lack of information on sight‐specific radiation differences comparability is limited. Nevertheless, in the present study, bone resorption rates 1 year after implantation were only slightly increased compared with most rates found in studies on implants in non‐irradiated patients (Pardal‐Peláez et al., 2020).…”

Section: Discussioncontrasting

confidence: 90%

Influence of implant‐specific radiation doses on peri‐implant hard and soft tissue: An observational pilot study

Neckel

Wagendorf

Sachse

et al. 2020

Clinical Oral Implants Res

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Objectives The aim of this study was to investigate the influence of real implant‐bed‐specific radiation doses on peri‐implant tissue health in head and neck cancer (HNC) patients after radiotherapy. Material and methods Specific radiation doses in the area of 81 implants, in 15 irradiated HNC patients, were analyzed by matching data from the radiotherapy planning system with those of three‐dimensional follow‐up scans after implantation. Peri‐implant bone resorption was measured radiographically after 1 and 3 years, and peri‐implant tissue health was evaluated clinically. Individual parameters, such as age, gender, and localization, regarding the implant‐specific radiation dose distribution were analyzed statistically. Results The mean implant‐bed‐specific radiation dose was high, with 45.95 Gy to the mandible and 29.02 Gy to the maxilla, but significantly lower than the mean total dose to the tumor bed. Peri‐implant bone resorption correlated with local inflammation and plaque. After 1 year, women temporarily showed significantly more bone loss than men and implant‐specific radiation dose had a significant impact on peri‐implant bone loss after 3 years. Conclusions The presented method is a feasible option to define precise implant‐bed‐specific radiation doses for research or treatment planning purposes. Implant‐based dental restoration after radiotherapy is a relatively safe procedure, but a negative radiation dose‐dependent long‐term effect on peri‐implant bone resorption calls for interdisciplinary cooperation between surgeons and radio‐oncologists to define high‐risk areas.

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Section: Discussioncontrasting

confidence: 90%

Influence of implant‐specific radiation doses on peri‐implant hard and soft tissue: An observational pilot study

Neckel

Wagendorf

Sachse

et al. 2020

Clinical Oral Implants Res

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“…Despite being composed of only 2 studies, the present meta-analysis comparing the MBL between IL and CL in individuals with DM2 after 12 months of follow-up showed no difference between the two techniques. These data contradict a meta-analysis of nondiabetic patients published in 2020 [ 34 ]. In their study, reduced crestal bone loss was found in conventional delayed loading of implants compared to immediately loaded implants.…”

Section: Discussioncontrasting

confidence: 85%

Survival rate and peri-implant evaluation of immediately loaded dental implants in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis

et al. 2021

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Objectives To evaluate the survival rate, success rate, and peri-implant biological changes of immediately loaded dental implants (ILs) placed in type 2 diabetic patients (DM2). Materials and methods The present study was registered on PROSPERO and followed the PRISMA checklist. The search was performed by the first reviewer in January 2021. The electronic databases used were MEDLINE via PubMed, Cochrane, BVS, Web of Science, Scopus, LIVIVO, and gray literature. The risk of bias analysis was performed using an instrument from the Joanna Briggs Institute. Results A total of 3566 titles and abstracts were obtained. The qualitative synthesis included 7 studies, while the quantitative synthesis included 5 studies. The meta-analysis of IL in individuals with DM2 compared to nondiabetic individuals showed no significant difference among the groups regarding the survival rate of dental implants (RR = 1.00, 95% CI 0.96–1.04; p = 0.91; I2 = 0%), even if the patient had poor glycemic control (RR = 1.08, 95% CI 0.87–1.33; p = 0.48; I2 = 70%). Meta-analysis of marginal bone loss in IL compared to conventional loading in DM2 patients also showed no significant difference (mean difference = − 0.08, 95% CI − 0.25–0.08; p = 0.33; I2 = 83%). Conclusions Type 2 diabetes mellitus does not seem to be a risk factor for immediately loaded implants if the glycemic level is controlled, the oral hygiene is satisfactory, and the technical steps are strictly followed. Clinical relevance Rehabilitation in diabetic individuals is more common due to the highest prevalence of edentulism in this population. It is essential to establish appropriate protocols for loading dental implants.

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“…Compared with conventional loading, immediate loading is associated with a higher incidence of implants failure [ 35 ]. And the risk of early loss of implants in the immediate loading group is higher than that in the delayed loading group [ 36 ]. Many clinical researches focus on bone resorption of immediate implants, but few basic researches about the mechanisms between immediate implants and bone resorption especially under tension stimulation.…”

Section: Discussionmentioning

confidence: 99%

Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation

Wang

Qiao

et al. 2021

Cell Death Dis

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With an increasing aging society, China is the world’s fastest growing markets for oral implants. Compared with traditional oral implants, immediate implants cause marginal bone resorption and increase the failure rate of osseointegration, but the mechanism is still unknown. Therefore, it is important to further study mechanisms of tension stimulus on osteoblasts and osteoclasts at the early stage of osseointegration to promote rapid osseointegration around oral implants. The results showed that exosomes containing circ_0008542 from MC3T3-E1 cells with prolonged tensile stimulation promoted osteoclast differentiation and bone resorption. Circ_0008542 upregulated Tnfrsf11a (RANK) gene expression by acting as a miR-185-5p sponge. Meanwhile, the circ_0008542 1916-1992 bp segment exhibited increased m6A methylation levels. Inhibiting the RNA methyltransferase METTL3 or overexpressing the RNA demethylase ALKBH5 reversed osteoclast differentiation and bone resorption induced by circ_0008542. Injection of circ_0008542 + ALKBH5 into the tail vein of mice reversed the same effects in vivo. Site-directed mutagenesis study demonstrated that 1956 bp on circ_0008542 is the m6A functional site with the abovementioned biological functions. In conclusion, the RNA methylase METTL3 acts on the m6A functional site of 1956 bp in circ_0008542, promoting competitive binding of miRNA-185-5p by circ_0008542, and leading to an increase in the target gene RANK and the initiation of osteoclast bone absorption. In contrast, the RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with miRNA-185-5p to correct the bone resorption process. The potential value of this study provides methods to enhance the resistance of immediate implants through use of exosomes releasing ALKBH5.

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Implant loss and crestal bone loss in immediate versus delayed load in edentulous mandibles: A systematic review and meta-analysis

Cited by 22 publications

References 16 publications

Influence of implant‐specific radiation doses on peri‐implant hard and soft tissue: An observational pilot study

Influence of implant‐specific radiation doses on peri‐implant hard and soft tissue: An observational pilot study

Survival rate and peri-implant evaluation of immediately loaded dental implants in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis

Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation

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